Secondary Glaucoma Accompanied with Primary Familial Amyloidosis

Tsukahara, Shigeo; Matsuo, Toshihiko

doi:10.1159/000308666

Cited by 32 publications

(13 citation statements)

References 12 publications

(24 reference statements)

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“…In these symp toms, gastrointestinal and nephropathological symptoms were not found in the previously reported cases [ Tsukahara and Matsuo, 1977).…”

Section: Discussioncontrasting

confidence: 39%

“…In a previous paper, it was reported that familial primary amyloidosis showed many varieties of ocular symptoms; namely, pupil lary disorder, vitreous opacities, secondary glaucoma and the decrease of Iacrimation [ Tsukahara and Matsuo, 1977]. However, retinal vascular lesions have not been found in this series, although fluorescein angiog raphy was done in several cases.…”

Section: Introductionmentioning

confidence: 62%

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Fluorographical Findings in Familial Primary Amyloidosis

Tsukahara¹,

Matsuo²

1978

Ophthalmologica

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“…In these symp toms, gastrointestinal and nephropathological symptoms were not found in the previously reported cases [ Tsukahara and Matsuo, 1977).…”

Section: Discussioncontrasting

confidence: 39%

Section: Introductionmentioning

confidence: 62%

Fluorographical Findings in Familial Primary Amyloidosis

Tsukahara¹,

Matsuo²

1978

Ophthalmologica

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“…[7][8][9][10] Although the onset of secondary glaucoma is a well-known complication in patients with FAP, knowledge of the clinical course and prognosis of this condition is far from satisfactory. 8,11,12 Recent developments in liver transplantation have led to the elon-CLINICAL SCIENCES gation of life expectancies in patients with FAP, which may also influence the significance and clinical course of ocular complications. In addition, although recently developed molecular biological techniques can identify exact mutations in the TTR gene and proteins in patients with FAP, 13,14 the relationship between the clinical features of ocular complications and the different TTR mutations has not previously been determined.…”

Section: Discussionmentioning

confidence: 99%

Secondary Glaucoma in Patients With Familial Amyloidotic Polyneuropathy

Kimura

Ando

Fukushima³

et al. 2003

Arch Ophthalmol

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To elucidate the clinical features and surgical outcomes of the treatment of secondary glaucoma associated with transthyretin (TTR)-related familial amyloidotic polyneuropathy (FAP).Design: Retrospective case study.Participants: Forty-nine Japanese patients with FAP.Methods: For all patients, measurement of bestcorrected visual acuity, intraocular pressure, and visual fields as well as slitlamp and ocular fundus examinations were conducted and compared. In addition, the exact mutation of the amyloidogenic TTR variants was analyzed for all 49 patients with FAP. The TTR mutations included amyloidogenic TTR (ATTR) Val30Met in 41 patients, ATTR Tyr114Cys in 6, ATTR Ser50Ile in 1, and a compound heterozygous mutation of ATTR Val30Met + Arg104His in 1. Results:The onset of secondary glaucoma was defined as elevation of intraocular pressure and glaucomatous changes in visual field defects. Secondary glaucoma was detected in 12 (24%) of the 49 patients. The incidence of secondary glaucoma in patients with the Val30Met mutation (17%) was lower than for the other FAP genotypes (P=.02 using the 2 test). Of 20 glaucomatous eyes,

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“…39 In the autosomal dominant condition, familial amyloidotic polyneuropathy, glaucoma is the most common ocular manifestation.…”

Section: Primary Amyloidosismentioning

confidence: 99%

Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

M¹,

Gupta²

2017

jemds

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BACKGROUNDPseudoexfoliation syndrome is a systemic disorder characterised by the deposition of white dandruff-like material within the anterior segment of the eye and other organs such as the heart, lungs and kidneys. The deposition of this material in the trabecular meshwork can result in aqueous flow obstruction, raised intraocular pressure and glaucoma. In fact, pseudoexfoliation glaucoma is the most common form of secondary open-angle glaucoma. In contrast to primary open-angle glaucoma, this disease runs a more aggressive clinical course with high intraocular pressure at onset, faster rates of progression, poor response to medical therapy and increased need for surgical intervention.

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Secondary Glaucoma Accompanied with Primary Familial Amyloidosis

Cited by 32 publications

References 12 publications

Fluorographical Findings in Familial Primary Amyloidosis

Fluorographical Findings in Familial Primary Amyloidosis

Secondary Glaucoma in Patients With Familial Amyloidotic Polyneuropathy

Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

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