Secondary Cutaneous Nodular AA Amyloidosis in a Patient With Primary Sjögren Syndrome and Celiac Disease

Katsikas, Georgios; Maragou, M.; Rontogianni, D; Gouma, Paraskevi; Koutsouvelis, Ioannis; Kappou-Rigatou, Iris

doi:10.1097/rhu.0b013e318163815f

Cited by 20 publications

(10 citation statements)

References 13 publications

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“…Although in none of these cases has been effectively demonstrated a pathogenetic link between the diseases, some of these associations are more common. Particularly lupus erythematosus [113], dermatomyositis [114], vitiligo [115], Behçet disease [116], linear IgA bullous dermatosis [117], and also both skin and mucosal manifestations of lichen [118, 119] are the most frequently reported, while prurigo nodularis [120], erythema nodosum [121], necrolytic migratory erythema [122], porphyria [123], cutaneous amyloidosis [124], pityriasis rubra pilaris [125], erythroderma [126], partial lipodystrophy [127], generalized acquired cutis laxa [128], ichthyosis [129], atypical mole syndrome, and congenital giant nevus [130] result very rare.…”

Section: Other Cd-associated Skin Conditionsmentioning

confidence: 99%

Celiac Disease and Dermatologic Manifestations: Many Skin Clue to Unfold Gluten-Sensitive Enteropathy

Caproni

Bonciolini

D’Errico

et al. 2012

Gastroenterology Research and Practice

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Cutaneous manifestations of intestinal diseases are increasingly reported both in the adult and in the children, and this association cannot longer be considered a simple random. Besides the well-known association between celiac disease (CD) and dermatitis herpetiformis (DH), considered as the cutaneous manifestation of gluten-dependent enteropathy, is more frequently reported also the association with other mucocutaneous diseases. Among these there are both autoimmune, allergic, and inflammatory diseases, but also a more heterogeneous group called miscellaneous. The knowledge about pathogenic, epidemiological, clinical, and diagnostic aspects of CD is increasing in recent years as well as those about DH, but some aspects still remain to be defined, in particular the possible pathogenetic mechanisms involved in the association between both CD and DH and CD and other immunological skin diseases. The aim of this paper is to describe the skin diseases frequently associated with CD, distinguishing them from those which have a relationship probably just coincidental.

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Section: Other Cd-associated Skin Conditionsmentioning

confidence: 99%

Celiac Disease and Dermatologic Manifestations: Many Skin Clue to Unfold Gluten-Sensitive Enteropathy

Caproni

Bonciolini

D’Errico

et al. 2012

Gastroenterology Research and Practice

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“…Secondary cutaneous amyloidosis is an entity of systemic amyloidosis in which amyloid can be secondarily located in the skin and others organs. In the case of the secondary cutaneous amyloidosis, the amyloid protein A (AA) is involved (Katsikas et al, 2008). Also, amyloid light chain has been involved in several cases of systemic amyloidosis in the skin (Feito-Rodriguez et al, 2008).…”

Section: Cutaneous and Neurodegenerative Amyloidosismentioning

confidence: 99%

Association of Skin with the Pathogenesis and Treatment of Neurodegenerative Amyloidosis

Clos¹,

Kayed²,

Lasagna‐Reeves³

2012

Front. Neur.

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Amyloidosis are a large group of conformational diseases characterized by abnormal protein folding and assembly which results in the accumulation of insoluble protein aggregates that may accumulate systemically or locally in certain organs or tissue. In local amyloidosis, amyloid deposits are restricted to a particular organ or tissue. Alzheimer’s, Parkinson’s disease, and amyotrophic lateral sclerosis are some examples of neurodegenerative amyloidosis. Local manifestation of protein aggregation in the skin has also been reported. Brain and skin are highly connected at a physiological and pathological level. Recently several studies demonstrated a strong connection between brain and skin in different amyloid diseases. In the present review, we discuss the relevance of the “brain–skin connection” in different neurodegenerative amyloidosis, not only at the pathological level, but also as a strategy for the treatment of these diseases.

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“…The hair follicle, for example, is both target for and source of immunomodulatory stress mediators, similar to the hypothalamus–pituitary–adrenal axis (66,68,74). It is also well known that certain proteins are altered by inflammation, thus leading to the formation of amyloid deposits (75–79) in brain, skin and other organs (38,80). In skin, this type of amyloid is most often referred to as AA‐amyloid, because serum amyloid A (SAA) acts as the precursor protein (11).…”

Section: Brain–skin Axismentioning

confidence: 99%

Amyloid in skin and brain: What′s the link?

Schreml

Kaiser

Landthaler

et al. 2010

Experimental Dermatology

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For too long, amyloids have been under general suspicion to merely cause diseases. In recent years, we have learned that these interesting proteins may also fulfill important biological tasks. Moreover, recent publications show emerging evidence for a so-called brain-skin axis. This viewpoint paper aims to address the question what is known about the link between brain and skin based on the literature available for two diseases caused by amyloid formation: Alzheimer¢s disease (AD) and cutaneous amyloidoses. In addition, we acquaint the reader with a different perspective on the role of amyloid in skin and brain.

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Secondary Cutaneous Nodular AA Amyloidosis in a Patient With Primary Sjögren Syndrome and Celiac Disease

Cited by 20 publications

References 13 publications

Celiac Disease and Dermatologic Manifestations: Many Skin Clue to Unfold Gluten-Sensitive Enteropathy

Celiac Disease and Dermatologic Manifestations: Many Skin Clue to Unfold Gluten-Sensitive Enteropathy

Association of Skin with the Pathogenesis and Treatment of Neurodegenerative Amyloidosis

Amyloid in skin and brain: What′s the link?

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