Secondary corneal amyloidosis: clinical and pathohistological examinations

Klemen, U. M.; Kulnig, W; Radda, T. M.

doi:10.1007/bf02175945

Cited by 11 publications

(2 citation statements)

References 8 publications

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“…This condition has been asso ciated with retrolental fibroplasia, phlyc tenular keratoconjunctivitis, lipoid degen eration. penetrating wound, keratokonus, buphthalmos, and trichiasis [1][2][3][4][5][6]. To our knowledge, only a few reported cases have been described of secondary corneal amyloi dosis caused by trichiasis [4.…”

Section: Introductionmentioning

confidence: 99%

Secondary Localized Amyloidosis of the Cornea Caused by Trichiasis

Hayasaka¹,

Setogawa²,

Ohmura³

1987

Ophthalmologica

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A 43-year-old woman complained of gradual visual impairment, foreign body sensation, and a white mass in the right eye. Trichiasis and corneal excrescence were observed. A systemic examination revealed no concurrent disease; the family history was noncontributory. A lamellar keratoplasty was performed. An amyloid deposit was found in the excised specimen histopathologically. Secondary localized amyloidosis of the cornea caused by trichiasis is a rare condition.

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Section: Introductionmentioning

confidence: 99%

Secondary Localized Amyloidosis of the Cornea Caused by Trichiasis

Hayasaka¹,

Setogawa²,

Ohmura³

1987

Ophthalmologica

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“…Previous studies have reported that Bowman’s layer is sometimes destroyed by amyloid aggregation. 2 , 5 , 6 , 9 Usually, tissue sampling during the early stages is difficult to perform from an ethical point of view, and we were only able to examine the histology of advanced cases of SCA. Moreover, these histological examinations do not always reflect the in vivo structure.…”

Section: Discussionmentioning

confidence: 99%

Findings of secondary corneal amyloidosis with ultrahigh-resolution optical coherence tomography

Araki-Sasaki¹,

Osakabe²,

Fukuoka³

et al. 2014

OPTH

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PurposeTo describe observations by ultrahigh-resolution optical coherence tomography (OCT) in a secondary corneal amyloidosis (SCA) patient with histological analysis of excised tissue. A unique finding under OCT of her fellow eye is also described.CaseA 39-year-old female had suffered from trichiasis in both of her eyes for more than 30 years. Slit-lamp examination showed a milky-white soft mass on her left cornea and a linear opacity on the fellow cornea at the cilia-attached region. OCT demonstrated the presence of a mass region within a thin epithelial layer and no destruction of Bowman’s layer in her left cornea. In the fellow cornea, which exhibited a linear opacity, a high-density spot in Bowman’s layer was observed at the cilia-attached region covered by the epithelial layer, with normal thickness. Histological examination of the excised cornea showed that the mass was positive with both Congo red and antilactoferrin antibody.ConclusionSCA, amyloid gradually accumulates above Bowman’s layer, occupying the epithelial layer, with no destruction of Bowman’s layer until the advanced stage. A high-density spot in Bowman’s layer might be the first stage of SCA.

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