Secondary chondrosarcoma of the lumbar spine in hereditary multiple exostoses

Mesfin, Addisu; Ghermandi, Riccardo; Castiello, Emanuela; Donati, Davide María; Boriani, Stefano

doi:10.1016/j.spinee.2013.03.056

Cited by 3 publications

(2 citation statements)

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“…13 Differential considerations for HME include solitary osteochondroma, multiple enchondromatosis, osteoblastoma, aneurysmal bone cyst, and chondrosarcoma. 11,18,32 Although there is no consensus with regard to the definition of the critical path to diagnosis, it is generally agreed that a skeletal survey should be performed once the affected individual reaches skeletal maturity. The survey is used for subsequent comparison should concerns arise.…”

Section: Discussionmentioning

confidence: 99%

Osteochondroma and Spinal Cord Compression in a Patient With Hereditary Multiple Exostoses: A Case Report

Zoboski

2017

Journal of Chiropractic Medicine

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Objective: The purpose of this report was to describe the presentation of a patient with hereditary multiple exostoses and thoracic spinal cord compression from an osteochondroma. Clinical Features: A 31-year-old female presented to a chiropractic clinic with a history of hereditary multiple exostoses and back pain that had existed since the age of 16 years. She had a past medical history that was remarkable for 3 prior surgeries for mass removal. Examination revealed a left upper midscapular mass with decreased sensation. Intervention/Outcome: Magnetic resonance imaging, computed tomography, and biopsy led to a diagnosis of osteochondroma. These diagnostic modalities confirmed that there was no malignant degeneration. Initial magnetic resonance imaging revealed a large expansive lesion involving the left posterior elements at the region of T3-T4. Subsequent thoracic hemilaminectomy and resection of the spinal tumor with posterior instrumentation and stabilization from T2-T5 resulted in 90% overall subjective improvement. Conclusions: A detailed case history, thorough examination, guided advanced imaging, and biopsy provide important information for the diagnosis and appropriate treatment of expansive lesions in patients with hereditary multiple exostoses. (J Chiropr Med 2017;16:72-77)

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Section: Discussionmentioning

confidence: 99%

Osteochondroma and Spinal Cord Compression in a Patient With Hereditary Multiple Exostoses: A Case Report

Zoboski

2017

Journal of Chiropractic Medicine

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“…Malignant transformation into secondary chondrosarcoma is still the most feared of all complications of HMO. [1,7,9] Paulino Pereira et al reported the following complications occurring up to 90 days after chondrosarcomas resections; dural rupture, respiratory failure, deep infection, fistula (pleuroincisional), cardiac arrest during surgery, pneumothorax, sepsis, instrumentation failure, recurrence with spinal cord injuries, sternal osteomyelitis, and atrial thrombus. [10]…”

Section: Complications Of Malignant Transformationmentioning

confidence: 99%

Chondrosarcoma secondary to hereditary multiple osteochondromas with spinal cord compression: A case report and systematic review

Silva,

Monteiro,

Silva

et al. 2023

Surgical Neurology International

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Background: Hereditary multiple osteochondromas (HMOs) are a rare genetic disorder characterized by the formation of multiple benign osteochondromas that can undergo malignant transformation into chondrosarcoma. Case Description: A 24-year-old male with a history of HMO and osteochondroma surgery 4 years ago, presented with back pain and paresthesias. The magnetic resonance showed a right paravertebral infiltrating mass at the T12–L1 level causing spinal cord compression. Following en bloc resection of the tumor, the patient’s symptoms/ signs resolved. The final pathological diagnosis was consistent with a chondrosarcoma. Conclusion: Chondrosarcomas secondary to HMO with spinal cord compression are rare. These patients often presenting with significant myelopathy/cord compression should undergo gross total resection where feasible to achieve the best outcomes.

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