Secondary cancer after meningioma diagnosis: an Israeli national study

Lassan, Maya Ben; Laitman, Yael; Keinan-Boker, Lital; Silverman, Barbara; Friedman, Eitan

doi:10.1007/s10552-022-01609-3

Cited by 2 publications

(12 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When comparing the studies, the heterogeneity test results were highly statistically significant (Cochran Q = 92.9; df = 12; P < .001) with an I 2 of 93%, indicating that the between-study heterogeneity was high. Therefore, a random-effects model was chosen for the meta-analysis.…”

Section: Resultsmentioning

confidence: 98%

“…English-language full text was not available for 26 records; hence, they were excluded. Finally, 53 studies were included for this systematic review: 27 case reports, 14 case series and 12 cancer registry studies . The case reports, case series, and cancer registry studies described a total of 2238 individual patients diagnosed with both pathologies, including patients with intracranial collision tumors.…”

Section: Resultsmentioning

confidence: 99%

“…In female patients with meningioma, we found approximately 10-fold higher odds of developing breast cancer during their lifetime based on 13 cohorts . In previous literature, the risk of having breast cancer while diagnosed with a meningioma was explored using state and national cancer registries.…”

Section: Discussionmentioning

confidence: 99%

“…Of 13 studies 6,7,39,41,42,45,47,48,50-52,55,57 assessed for the meningioma population, 6 expressed the risk of developing breast cancer as SIR or similar ratios. The most recent study, conducted by Ben Lassan et al, 57 reported an SIR of 1.6 (95% CI, 1.4-1.9) for invasive breast cancer and 1.7 (95% CI, 1-2.6) for in situ breast cancer in their cohort of female individuals diagnosed with meningioma. A study by Rao…”

Section: Study Selectionmentioning

confidence: 99%

“…53 Studies included in systematic review 18 Studies included in meta-analysis6,7,39,41,42,45,47,48,[50][51][52]55,57 26 Records excluded 18 Only abstracts available 8 No full text in English available 79 more advanced tumor stage (stage IV: SIR, 2.39; 95% CI, 1.71-3.25; P = .05) were at a higher risk of developing meningioma. Patients in subgroups according to hormone receptor expression and treatment modality were at comparable risk vs the overall population.…”

mentioning

confidence: 99%

See 4 more Smart Citations

The Association Between Meningioma and Breast Cancer

et al. 2023

View full text Add to dashboard Cite

ImportanceA potential relationship between meningioma and breast cancer was suggested 70 years ago. However, to date, no conclusive evidence is available on this topic.ObjectiveTo provide a comprehensive review of the literature on the association of meningioma with breast cancer, supported by a meta-analysis.Data SourcesA systematic PubMed search was performed up to April 2023 to identify articles on the association of meningioma with breast cancer. The following key words were used strategically: meningioma, breast cancer, breast carcinoma, association, relation.Study SelectionAll studies reporting women diagnosed with meningioma and breast cancer were identified. The search strategy was not limited by study design or publication date but only included articles in English. Additional articles were identified via citation searching. Studies reporting a complete population of meningiomas or breast cancer patients throughout a specific study period and a proportion of patients with a second pathology could be used for the meta-analysis.Data Extraction and SynthesisData extraction was performed by 2 authors in accordance with the Preferred Reporting Items for Systematic Reviews (PRISMA) statement. Meta-analyses regarding both populations were performed using a random-effects model. Risk of bias was assessed.Main Outcomes and MeasuresThe main measures were whether there was an increased prevalence of breast cancer in female patients with meningioma and whether there was an increased prevalence of meningioma in female patients with breast cancer.ResultsA total of 51 retrospective studies (case reports, case series, and cancer registry reports) describing 2238 patients with both diseases were identified; 18 studies qualified for prevalence analyses and meta-analysis. The random-effects meta-analysis (13 studies) revealed a significantly greater prevalence of breast cancer in female patients with meningioma than in the overall population (odds ratio [OR], 9.87; 95% CI, 7.31-13.32). Meningioma incidence in patients with breast cancer (11 studies) was greater than that in the baseline population; however, the difference according to the random-effects model was not statistically significant (OR, 1.41; 95% CI, 0.99-2.02).Conclusions and RelevanceThis large systematic review and the meta-analysis on the association between meningioma and breast cancer found nearly 10-fold higher odds of breast cancer in female patients with meningioma compared with the general female population. These findings suggest that female patients with meningioma should be screened more intensively for breast cancer. Further research is required to identify the factors causing this association.

show abstract

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

The Association Between Meningioma and Breast Cancer

et al. 2023

View full text Add to dashboard Cite

show abstract

A Bidirectional Mendelian Randomization Study Revealed Genetic Evidence of Breast Cancer as a Risk Factor for Meningioma

Zhou,

Gong,

Deng

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Although preceding observational research mentioned a potential connection between meningioma and breast cancer, verifying an unambiguous causal relationship has turned out problematic. Aiming to determine if breast cancer and the risk of meningioma intersect, we utilized a bidirectional two-sample Mendelian randomization (MR) analysis in this study. Besides, we investigated the influence of various estrogen receptor (ER) phenotypes on that association. Methods Breast cancer data from the Breast Cancer Association Consortium (BCAC) coupled with meningioma data from the FinnGen cohort were adopted in our investigation. Total participants of European descent were divided into four groups: 228,951 individuals (122,977 cases of breast cancer and 105,974 controls), 175,475 individuals (69,501 cases of ER-positive breast cancer and 105,974 controls), 127,442 individuals (21,468 cases of ER-negative breast cancer and 105,974 controls), and 287,614 individuals (1.237 cases of meningioma and 286,377 controls). The MR research, which utilized the power of the inverse variance weighting (IVW), weighted median (WM), and MR-Egger means, used tightly opted instrumental SNPs that were profoundly connected with exposure. Results According to the results of our forward MR study, there was a significant causal correlation between total breast cancer on meningioma (MR-Egger: OR = 1.4, 95% CI = 1.05–1.90, P = 0.022; WM: OR = 1.3, 95% CI = 1.02–1.50, P = 0.0248; IVW: OR = 1.2, 95% CI = 1.05–1.4, P = 0.0075). Furthermore, there was a probable causative relationship among ER-positive (ER+) breast cancer on meningioma (IVW: OR = 1.20, 95% CI: 1.03–1.30, P = 0.014), whereas no apparent connection between ER-negative breast cancer on meningioma emerged. Meningioma had little impact on the risk of breast cancer and breast cancer with different ER states, as shown to the inverse MR analysis drawing on the IVW, MR-Egger, and WM tests. Conclusion Following what comes of our forward MR investigation, there existed an unambiguous connection between the breast cancer in the population of European descent on meningioma. Likewise, we uncovered a potential combination referring to a causative relationship among ER + breast cancer on meningioma. However, there was no confirmation that suffering ER-breast cancer increases the possibility to grow meningioma. Furthermore, there was no causal relationship between overall breast cancer and breast cancer with different ER status on meningioma by our reverse MR examination.

show abstract

Secondary cancer after meningioma diagnosis: an Israeli national study

Cited by 2 publications

References 18 publications

The Association Between Meningioma and Breast Cancer

The Association Between Meningioma and Breast Cancer

A Bidirectional Mendelian Randomization Study Revealed Genetic Evidence of Breast Cancer as a Risk Factor for Meningioma

Contact Info

Product

Resources

About