2017
DOI: 10.14499/indonesianjpharm28iss1pp26
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SECONDARY BIOACTIVE METABOLITE GENE CLUSTERS IDENTIFICATION OF ANTICANDIDA-PRODUCING Streptomyces Sp. GMR22 ISOLATED FROM WANAGAMA FOREST AS REVEALED BY GENOME MINING APPROACH

Abstract: Streptomyces are a group of Gram-positive bacteria belonging to the Actinobacteria class, which are among the most important bacteria for producing secondary bioactive metabolites such as antibiotics, chemotherapeutics, insecticides and other high-value chemicals. Genome mining of gene clusters that encode the biosynthetic pathways for these metabolites has become a key methodology for novel compound discovery. Recently, we have isolated the Streptomyces sp. GMR22 from Cajuput rhizospheric soil at Wanagama For… Show more

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Cited by 14 publications
(17 citation statements)
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“…All previous types have been studied for their antimicrobial potential, but particularly non‒ribosomal peptide synthetase (NRPS) and polyketide synthase (PKS I and II) pathways, which are thought to be responsible for antibiotic synthesis in actinobacteria 63 . The number of BGCs of secondary metabolites observed is higher than the average usually reported for other mesophilic Streptomyces strains, with ranges from 20 to 30 gene clusters 62,64,65 , with exceptions such as Streptomyces strains isolated from Indonesia 66 and China 67 , which had more than 50 clusters for secondary metabolites. As suggested for Antarctic Pseudoalteromonas strains ‒with a maximum of 19 biosynthetic gene clusters‒ 16 , it have been thought that a greater number of secondary metabolites could be driven by the adaptation and evolution of Streptomyces strains to survive and proliferate under harsh Antarctic conditions.…”
Section: Resultscontrasting
confidence: 71%
“…All previous types have been studied for their antimicrobial potential, but particularly non‒ribosomal peptide synthetase (NRPS) and polyketide synthase (PKS I and II) pathways, which are thought to be responsible for antibiotic synthesis in actinobacteria 63 . The number of BGCs of secondary metabolites observed is higher than the average usually reported for other mesophilic Streptomyces strains, with ranges from 20 to 30 gene clusters 62,64,65 , with exceptions such as Streptomyces strains isolated from Indonesia 66 and China 67 , which had more than 50 clusters for secondary metabolites. As suggested for Antarctic Pseudoalteromonas strains ‒with a maximum of 19 biosynthetic gene clusters‒ 16 , it have been thought that a greater number of secondary metabolites could be driven by the adaptation and evolution of Streptomyces strains to survive and proliferate under harsh Antarctic conditions.…”
Section: Resultscontrasting
confidence: 71%
“…Meanwhile, the genomic studies of Streptomyces provide a basis for better understanding of the secondary metabolism and the production of target bioactive metabolites, thus creating an opportunity to obtain novel bioactive compounds 86,87 . With the availability of NGS technology, the whole genome of strain MUSC 1J T was subjected to sequencing.…”
Section: Discussionmentioning
confidence: 99%
“…To the best of our knowledge, only two strains with a higher number of BGCs than S-2 have been described: S. griseochromogenes ATCC-14511 [13] and Streptomyces sp. GMR22 [64], with 59 and 63 BGCs respectively. However, those analyses were performed with an older version of the anti-SMASH database.…”
Section: Discussionmentioning
confidence: 99%