Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease

Beaton, Andrea; Okello, Emmy; Rwebembera, Joselyn; Grobler, Anneke; Engelman, Daniel; Alepere, Juliet; Canales, Lesley; Carapetis, Jonathan R.; DeWyer, Alyssa; Lwabi, Peter; Mirabel, Mariana; Mocumbi, Ana Olga; Murali, Meghna; Nakitto, Miriam; Ndagire, Emma; Nunes, Maria Carmo Pereira; Omara, Isaac Otim; Sarnacki, Rachel; Scheel, Amy; Wilson, Nigel; Zimmerman, Meghan; Zühlke, Liesl; Karthikeyan, Ganesan; Sable, Craig; Steer, Andrew C.

doi:10.1056/nejmoa2102074

Cited by 104 publications

(92 citation statements)

References 41 publications

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“…Regular penicillin treatment can prevent progression of latent RHD detected by such screening. 35 This study has also identified an association between ARF and the number of sugar-sweetened drinks consumed each day. People in New Zealand have high daily intakes of total sugars, 36 and sugar-sweetened beverages are readily available and affordable.…”

Section: Discussionmentioning

confidence: 72%

Risk factors for acute rheumatic fever: A case-control study

Baker

Gurney

Moreland

et al. 2022

The Lancet Regional Health - Western Pacific

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Section: Discussionmentioning

confidence: 72%

Risk factors for acute rheumatic fever: A case-control study

Baker

Gurney

Moreland

et al. 2022

The Lancet Regional Health - Western Pacific

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“…Nevertheless, we have demonstrated that a rapid single-view screening protocol can be performed in just over one-minute with a high degree of accuracy. School-based screening programs appear to be cost effective and reduce the risk of RHD overtime [5,18,19]. As new evidence emerges and technology improves, increased funding for RHD is needed to meaningfully reduce the global burden of disease [20].…”

Section: Discussionmentioning

confidence: 99%

“…Rheumatic heart disease (RHD) affects 33 million people in low and middle income countries and is the leading cause of cardiovascular death among children and young adults [1][2][3]. Echocardiography detects ten times the amount of subclinical RHD when compared with clinical screening and secondary prophylaxis with penicillin reduces the progression of disease [4,5]. Evidence increasingly supports simplified screening protocols which can be executed by well-trained allied health staff [6].…”

Section: Introductionmentioning

confidence: 99%

Saving time saves lives! A time focused evaluation of a single-view echocardiographic screening protocol for subclinical rheumatic heart disease

Johannsen¹,

Kaltenborn²,

Shroff³

2022

International Journal of Cardiology

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“…[5][6][7][8][9] Once identi ed, latent RHD appears to follow a heterogeneous course but recent evidence supports the bene t of secondary prophylaxis with penicillin. 10 While the World Heart Federation criteria serve as the gold standard for making a diagnosis of rheumatic heart disease, they are impractical for population-based screening programs due to time, cost, and resource availability. 11 Efforts to expand echocardiographic screening are focusing on simpli ed protocols, non-physician ultrasonographers, and portable ultrasound devices, including handheld ultrasound.…”

Section: Introductionmentioning

confidence: 99%

Assessing The Performance Characteristics of Handheld Ultrasound In A Rheumatic Heart Disease Screening Program

Kaltenborn

Zewde

Kirsch

et al. 2022

Preprint

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Background: Rheumatic heart disease affects 33 million people in low and middle income countries and is the leading cause of cardiovascular death among children and young adults. Penicillin prophylaxis has been shown to improve valvular function among patients with clinically silent or mild disease. Efforts to expand echocardiographic screening are focusing on simplified protocols, non-physician ultrasonographers, and portable ultrasound devices, including handheld ultrasound. Recent advances support the use of single-view screening protocols. With the increasing availability and low cost of handheld devices, prospective studies are needed to evaluate their performance in these settings. Methods: We conducted a cross-sectional pilot study among 19 at-risk school-children participating in a rheumatic heart disease screening program in Ethiopia comparing a handheld ultrasound device (Phillips Lumify) to a fully-equipped portable ultrasound machine (Sonosite M-Turbo). Results: Agreement between devices was similar for expert and non-expert review (84%). However, when reviewed by a non-expert the Lumify identified fewer screen-positive cases (p-value 0.083). We also compared non-expert to expert interpretation by device and found a significant difference in interpretation for the Lumify (p-value 0.025). There was a trend towards shorter jet length by color Doppler in the handheld ultrasound device for both expert and non-expert review. Conclusions: Our study highlights that screening echocardiograms for RHD may yield different results when a handheld ultrasound device is used.

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Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease

Cited by 104 publications

References 41 publications

Risk factors for acute rheumatic fever: A case-control study

Risk factors for acute rheumatic fever: A case-control study

Saving time saves lives! A time focused evaluation of a single-view echocardiographic screening protocol for subclinical rheumatic heart disease

Assessing The Performance Characteristics of Handheld Ultrasound In A Rheumatic Heart Disease Screening Program

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