Secondary Amyloidosis of the Bladder: A Case Report

Bender, Leon; Kelly, Charles E.

doi:10.1016/s0022-5347(17)62073-1

Cited by 15 publications

(4 citation statements)

References 6 publications

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“…Incidence.-Vesical amyloidosis is rare, 38 cases have been reported so far (Houtappel and Lauwers, 1960;Kinzel et al, 1961;Werner, 1961;Nagel, 1961Nagel, , 1962Grace and Walton, 1964;Krzeski, 1964;Hudson and Tingley, 1965;Narwani and Lingard, 1966;Sinkevichus and Liutkus, 1966;Lerut and Lerut, 1967;Bender and Kelly, 1969;Tripathi and Desautels, 1969;Missen and Tribe, 1970). These, together with our 4 new cases, make a total of 42 cases.…”

mentioning

confidence: 64%

“…The characteristic distribution of deposits in the systemic form, heavily in vascular sites and relatively sparingly in muscle, as compared to that of the localised variety may be a clue as to the type of disease. Our Case 4 is one of the 4 proved examples (Bender and Kelly, 1969;Missen and Tribe, 1970) of systemic amyloidosis with symptomatic bladder involvement. Such findings are of great significance not only from the therapeutic standpoint but also from that of prognosis.…”

Section: Discussionmentioning

confidence: 86%

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Amyloidosis of the Urinary Bladder

Malek

Greeene

2008

British Journal of Urology

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AMYLOIDOSIS is characterised by deposition, in various tissues, of a homogeneous, eosinophilic, hyaline material. Presently, most cases occur in a generalised form as a manifestation of an underlying plasma cell neoplasm (myeloma) or plasmacytic dyscrasia. On the other hand, most cases of symptomatic amyloid disease in the urinary bladder have occurred as an apparently solitary, localised tumefactive process. The lower urinary tract lesions of the disseminated form of the disease are rarely, if ever, symptomatic.In the detailed review of the literature by Kinzel, Harrison, and Utz in 1961, 5 new cases were reported. Since then, 4 new cases have been seen at the Mayo Clinic. These new cases, additional follow-up information on the previous 5 cases (Kinzel et al., 1961), and a detailed analysis of data pertaining to these and 33 cases reported by others, in which adequate data were available, form the bases of this report. Four more cases only .briefly mentioned by Tripathi and Desautels (1969) without sufficient data are not included in this report. REPORT OF CASESCase 1.-An 80-year-old woman with a history of urosepsis and interstitial cystitis-treated successfully at the Mayo Clinic in 1937 followed in 1965 (28 years later) by transurethral resection and fulguration of bladder lesions elsewhere for recurrent haematuria and dysuria-was again referred to us for further treatment. Her medical evaluation, results of routine blood tests, and excretory urogram were essentially normal. Urinalysis revealed microhzmaturia, pyuria, and mild proteinuria (negative for Bence Jones protein), and urine culture grew significant colonies of Aerobacter rerogenes.Cystoscopy revealed a '' smooth rounded mass several centimeters in diameter on the right side of the dome of the bladder and two masses, each 1 cm. in diameter, on the bladder side of the vesical neck at the 3 o'clock position ".These were biopsied and electrocoagulated, with a subsequent favourable response. The biopsy specimen revealed aggregates of amyloid involving the bladder muscle and blood vessels. Bone marrow biopsy and serum electrophoresis both gave normal results. A year later she underwent bilateral ureterosigmoidostomy for recurrence of her symptoms and a markedly contracted bladder with a trigonal lesion. The lesion proved to be a poorly differentiated (grade 3) infiltrating transitional cell carcinoma with squamous metaplasia. The patient died shortly thereafter from heart disease.Case 2.-A 40-year-old man with a history of vesical irritation, of 3 years' duration, suggestive of interstitial cystitis was examined at the Mayo Clinic in 1952; urological investigations were negative. He remained asymptomatic for 1 I years but returned in 1963 because of a bout of painless gross hzmaturia. The results of routine tests of blood and urine were normal, the urine culture was negative, and the excretory urogram was normal. Cystoscopy revealed a vesical diverticulum on the right side with an adjacent, elevated, reddened, irregular, malignant-appearing area which wa...

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confidence: 64%

Section: Discussionmentioning

confidence: 86%

Amyloidosis of the Urinary Bladder

Malek

Greeene

2008

British Journal of Urology

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“…El primero fue aportado por Bender y Nelly en 1969 13 . La serie más amplia, con 5 casos, fue publicada por Nurmi et al en 1987 14 , ya relacionándolos con hematuria masiva.…”

Section: Discussionunclassified

Amiloidosis vesical secundaria y hematuria masiva

López¹,

Echevarría²,

Saizar

et al. 2010

Actas Urol Esp

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“…Generally, cystoscopic findings are described as diffuse bleeding, 5 diffuse edema, 6 fine red web‐like trabeculation, 7 ulcer and raised beefy edematous lesions 8 . The mechanism of prolonged bleeding is thought to be the infiltration of vessel walls with amyloid, which prevents normal constriction in response to injury 7 .…”

Section: Discussionmentioning

confidence: 99%

Secondary amyloidosis of the bladder causing macroscopic hematuria

et al. 2001

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Bladder involvement in amyloidosis is unusual. The case of an 80-year-old man with macroscopic hematuria caused by secondary amyloidosis of the bladder is described. Cystoscopic examination revealed only a diffuse edematous area and bleeding. No tumor-like lesions were identified. Transurethral biopsy revealed amyloid deposits. Macroscopic hematuria disappeared spontaneously after cystoscopy and bladder biopsy. The patient has been followed up without treatment and is currently free of symptoms.

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Secondary Amyloidosis of the Bladder: A Case Report

Cited by 15 publications

References 6 publications

Amyloidosis of the Urinary Bladder

Amyloidosis of the Urinary Bladder

Amiloidosis vesical secundaria y hematuria masiva

Secondary amyloidosis of the bladder causing macroscopic hematuria

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