Secondary Amyloidosis in Lepromatous Leprosy

Williams, Ralph C.; Cathcart, Edgar S.; Calkins, Evan; Fite, George L.; Rubio, José Barba; Cohen, Alan S.

doi:10.7326/0003-4819-62-5-1000

Cited by 41 publications

(3 citation statements)

References 8 publications

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“…The presence of M. leprae all along the sinusoids evidently showed that the spread of infection occurs through blood stream and the body tissue reacts to this insult by proliferation of reticulo-endothelial cells in the form of histiocytes in the liver and other organs 21 . Amyloidosis was seen in one patient who had extensive disease for the prolonged period (10 years). Its incidence has been variously reported ranging from 5.9% to 50% 22 . The higher incidence of it from Western Countries was due to the fact of dietary and/or environmental factors.…”

Section: Discussionmentioning

confidence: 99%

Hepato-protective role of indigenous drug LIV-52 in lepromatous leprosy

NIGAM,

DAYAL,

MUKHIJA

et al. 1982

Hansen. Int.

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The present study incorporates a study of 42 cases of lepromatous leprosy for hepatic involvement and role of indigenous herbal preparation in protecting the liver in leprosy. Liver was enlarged in 32 cases which was tender in 8 patients. Alteration in liver function irrespective of extent and duration of the illness (3 months to 10 years with mean duration of illness = 2 years 5 months) was mainly seen as uniform elevation of serum proteins (6.2-9.2 gms%, mean = 7.5 gms%) with hypoalbuminaemia (2.0-4.4 gms%, mean = 2.9 gms%). Highest level of serum bilirubin of 1.6 mg% was detected in 6 cases, emphasising the presence of leprous hepatitis. Raised level of serum transaminases (SGOT = 65.2 IU, SGPT = 78.7 IU) were proportionate to the liver and muscle involvement. Presence of characteristic granulomata in the liver around the central vein, periportal area and even distribution at various locations in the liver lobules were the most significant changes in 12 out of 15 liver tissues. Acid fast M. leprae were demonstrated in 12 patients. The present work emphasises the detection of hepatic involvement in the early stage of the disease and hepato-protective role of indigenous drug Liv-52 in lepromatous leprosy which usually lead to dreaded mutilated complications in the body.

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Section: Discussionmentioning

confidence: 99%

Hepato-protective role of indigenous drug LIV-52 in lepromatous leprosy

NIGAM,

DAYAL,

MUKHIJA

et al. 1982

Hansen. Int.

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“…There are many chronic diseases such as leprosy, chronic tuberculosis, and rheumatoid arthritis that predispose a patient to amyloidosis. Amyloidosis is much more common in American patients with leprosy than Mexican patients with the same disease ( 11 ) . I t has been postulated that diet may influence this difference.…”

Section: The Effect Of Casein Diet On the Development Of Amyloidosis mentioning

confidence: 99%

The Effect of Casein Diet on the Development of Amyloidosis in Hamsters

Irwin

Smith

1969

Experimental Biology and Medicine

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“…It is remarkable that while the incidence of leprous amyloidosis is high in the United States, it is low in Mexico and rare in the Orient [3,5]. Genetic factors, environment [7], and diet (including high animal fat and high cas ein diets) [8] have been implicated. The incidence of amyloid degenera tion seems to be greater in patients suffering repeated lepra reactions [3,4].1 The lesions may be even more common in patients with erythema nodosum leprosum, a cutaneous manifestation of reactional leprosy [3, 9].…”

Section: Review Kidneymentioning

confidence: 99%

Genitourinary Leprosy

Watson¹,

Gangai²,

Skinsnes³

1974

Urol Int

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The genitourologic aspects of leprosy are reviewed. (1) Renal complications are widespread and clinically significant. Amyloid degeneration is common in leprosy, particularly in the West. (2) Adrenal involvement is also seen. Clinical consequences, although not thoroughly evaluated, do not seem significant. (3) Testicular and epididymal involvement, universal in lepromatous leprosy, is of diagnostic and therapeutic importance, particularly in association with lepromatous gynecomastia, a clinical model of ‘acquired Klinefelter’s syndrome’. (4) The existence of venereal leprosy, postulated through the ages in folklore, is not borne out by scientific investigation. (5) The external genitalia are generally spared, although occasional involvement has been reported. (6) The ureters, bladder, and urethra are spared as are the prostate and seminal vesicles. (7) Abnormal urinalyses, reflecting renal impairment, are frequently seen. The frequency and significance of mycobacteriuria remain unsettled.

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Secondary Amyloidosis in Lepromatous Leprosy

Cited by 41 publications

References 8 publications

Hepato-protective role of indigenous drug LIV-52 in lepromatous leprosy

Hepato-protective role of indigenous drug LIV-52 in lepromatous leprosy

The Effect of Casein Diet on the Development of Amyloidosis in Hamsters

Genitourinary Leprosy

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