Secondary Amyloidosis Associated with Multiple Sclerosis

Abstract

BackgroundMultiple sclerosis (MS) is a demyelinating disease of the central nervous system. Secondary amyloidosis can occur as a complication of chronic systemic inflammatory and infectious diseases. Until now there has been no report of secondary amyloidosis associated with MS. We report herein a case of renal biopsy-proven secondary amyloidosis in a patient with MS.Case ReportA 41-year-old woman with MS was hospitalized due to aggravated quadriparesis and edema in both lower extremities. Laboratory findings showed nephrotic-range proteinuria and hypoalbuminemia. A percutaneous renal biopsy procedure was performed, the results of which revealed secondary amyloid-A-type amyloidosis associated with MS.ConclusionsThis is the first report of secondary amyloidosis associated with MS.

AA-amyloidosis in Autosomal Dominant Polycystic Kidney Disease Caused by Chronic Cyst Infections Lasting for 30 years

“…Therefore, AA amyloidosis occurs in patients with chronic inflammatory diseases such as rheumatoid arthritis (5), juvenile rheumatoid arthritis, inflammatory bowel disease (9), familial Mediterranean fever (10), microscopic polyangitis (11), Castleman's disease (12), Reiter's disease (13), Behcet's disease (14), Whipple disease (15) and multiple sclerosis (16).…”

Cartilage acidic protein 1, a new member of the beta-propeller protein family with amyloid propensity

“…They are well described in bacteria, fungi and mammals and in the latter are related to devastating diseases. Recent studies also point to a putative association between amyloidosis and multiple sclerosis . Amyloids have also been attributed biological functions and it is highly challenging to understand their origin, role, and why evolution retained this toxic protein fold.…”