Second unmanipulated allogeneic transplantation could be used as a salvage option for patients with relapsed acute leukemia post-chemotherapy plus modified donor lymphocyte infusion

Han, Tingting; Sun, Yu‐Qian; Liu, Yang; Yan, Chen‐Hua; Wang, Yu; Xu, Lei; Liu, Kai-Yan; Huang, Xiao‐Jun; Zhang, Xiaohui

doi:10.1007/s11684-021-0833-x

Cited by 1 publication

(1 citation statement)

References 62 publications

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“…Currently, there are few studies on the efficacy of HSCT2 in patients with relapsed/refractory AL treated with post-chemotherapy plus modified donor lymphocyte infusion (post-chemotherapy + m-DLI) after HSCT1. Therefore, one retrospective study analyzed the efficacy of HSCT2 in 28 patients with relapsed/refractory AL after chemotherapy and m-DLI ( 17 ). At a median follow-up of 918 days, 26 patients (92.9%) achieved CR, and 2 patients presented with persistent disease.…”

Section: Factors Affecting the Efficacy Of Hsct2mentioning

confidence: 99%

Advances in second hematopoietic stem cell transplantation

Yan,

Zhu,

Xiao

2024

Front. Immunol.

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Hematopoietic stem cell transplantation (HSCT) is a widely used treatment for malignant hematological diseases; however, some patients inevitably experience relapse. Therefore, for patients who relapse after the first HSCT (HSCT1), a standard treatment regimen must be developed. A second hematopoietic stem cell transplantation (HSCT2) is a possible treatment option. Several studies have analyzed the feasibility of HSCT2. Previous studies have shown that various factors may affect the efficacy of HSCT2, including the hematopoietic cell transplantation comorbidity index, duration of remission after HSCT1, occurrence of chronic graft-versus-host disease, and disease status before HSCT2. However, the selection of donors for HSCT2 does not affect the transplantation efficacy. HSCT2 also presents a risk of relapse, and the prognosis of patients after relapse is poor. Further research on the treatment of patients after relapse is warranted.

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Section: Factors Affecting the Efficacy Of Hsct2mentioning

confidence: 99%