Second‐trimester uterine artery Doppler pulsatility index and maternal serum PP13 as markers of pre‐eclampsia

Abstract

Late second-trimester PP13 alone is unlikely to be useful in predicting pre-eclampsia and early pre-eclampsia, and its prediction does not increase when coupled with second-trimester Doppler PI or other potential biochemical markers. Measuring between-trimester temporal changes may be worthy of further investigation.

Increased levels of cell-free hemoglobin, oxidation markers, and the antioxidative heme scavenger α1-microglobulin in preeclampsia

“…Although various plasma factor concentrations have been shown to be associated with PE (PP13, sFlt1, sEndogline and VCAM [51,52]), none so far has proven clinically useful. The results…”

Serum markers for pre-eclampsia: An update on the analytes to be determined in the first, second, and third trimester

“…In the second trimester, PP13 only detected early (severe) cases [78]. In the first trimester, however, more markedly decreased serum concentrations of this protein have been found [79] and recently confirmed [80]; ROC analysis yielded an AUC of 0.67.…”

Biomarkers in Preeclampsia

“…86 Second trimester levels of PP-13 (22e32 weeks) are not useful in predicting preeclampsia, and prediction did not improve when coupled with Doppler velocimetry. 89 An increase in cell-free fetal DNA has been described in women with an abnormal uterine Doppler and who developed preeclampsia. 126 Studies assessing the combination of Doppler with cell-free fetal DNA for predicting preeclampsia are not available.…”

“…88 Second trimester levels of PP-13 (22e32 weeks) taken at a single time point are not useful in predicting preeclampsia, and its prediction did not increase when coupled with Doppler velocimetry. 89 Combining first trimester PP-13 with other parameters may further improve predictive performance. Larger prospective studies are needed to determine whether PP-13 will be a valuable clinical marker for early prediction of preeclampsia.…”