Second trimester total human chorionic gonadotropin, alpha-fetoprotein and unconjugated estriol in predicting pregnancy complications other than fetal aneuploidy

Đurić, Koraljka; Škrablin, Snježana; Lešin, Joško; Kalafatić, Držislav; Kuvačić, Ivan; Suchanek, Ernest

doi:10.1016/s0301-2115(03)00081-2

Cited by 49 publications

(48 citation statements)

References 22 publications

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“…In another study, preterm delivery, preeclampsia and large for gestational age were found to be associated with only hCG levels of 3 MoM and the authors concluded that increased fetal surveillance is not warranted with lower values (25). Consistent with our results, a low uE3 level was suggested as an independent risk factor for adverse pregnancy outcome and is particularly associated with preeclampsia, in conjunction with IUGR, SGA, oligohydramnios, preterm delivery and stillbirth (9,12,26). In a meta-analysis by Morris et al Down's serum screening analytes were found to have low predictive accuracy for pre-eclampsia and small for gestational age.…”

Section: Discussionsupporting

confidence: 86%

“…Infants of mothers with hyperemesis have lower birth weights and the mothers are more likely to have infants that are small for gestational age (8). Although elevated maternal serum AFP level usually shows an elevated risk for neural tube defects, they are also related to adverse pregnancy outcomes such as preeclampsia, spontaneous abortion, preterm delivery, low birth weight, IUGR, oligohydramnios, placental abruption and stillbirth (9)(10)(11)(12), all of which are thought to be associated with abnormal placentation (13). In our study, a significant association between serum AFP values and IUGR was observed.…”

Section: Discussionmentioning

confidence: 99%

“…A retrospective trial found that increased antenatal surveillance for women with unexplained elevated AFP did not provide any benefit for detection of adverse events (19). Women with elevated second-trimester hCG values have been reported to have increased risks for preeclampsia, IUGR, small for gestational age (SGA) infants, preterm delivery, spontaneous abortion, stillbirth and placental abnormalities (9,12,(20)(21)(22). However, Ashour et al (23) suggested that the utility of hCG level as a screening test for preeclampsia was limited.…”

Section: Discussionmentioning

confidence: 99%

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Second trimester serum alpha-fetoprotein level is a significant positive predictor for intrauterine growth restriction in pregnant women with hyperemesis gravidarum

Özkaya¹,

Çakır²,

Çınar³

et al. 2011

J Turkish German Gynecol Assoc

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Second trimester serum alpha-fetoprotein level is a significant positive predictor for intrauterine growth restriction in pregnant women with hyperemesis gravidarum Objective: The aim of this study was to determine the association between three parameters of second trimester serum secreening and preterm labor and intrauterine growth restriction (IUGR) in patients with hyperemesis gravidarum (HG). Material and Methods:A prospective study on 429 pregnancies with HG was designed to determine the association between alpha-fetoprotein (AFP), unconjugated estriol (uE3), human chorionic gonadotropin (HCG) and pregnancy prognosis in terms of preterm labor, IUGR and birth weight.Results: In our study group the mean age of patients was 25.4±3.8years. Mean birth weight was 3180±555 g. Mean AFP, uE3, hCG levels in the study group were 1.44±0. Abstract ÖzetOriginal Investigation 220 Content

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Second trimester serum alpha-fetoprotein level is a significant positive predictor for intrauterine growth restriction in pregnant women with hyperemesis gravidarum

Özkaya¹,

Çakır²,

Çınar³

et al. 2011

J Turkish German Gynecol Assoc

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“…Although a high-risk triple screen in this study was associated with PIH, Oligo and operative delivery, none of the individual markers including AFP, HCG and UE3 showed any association with any of the adverse pregnancy/neonatal outcomes unlike earlier reports by others [7,8].…”

Section: Discussioncontrasting

confidence: 93%

Maternal Serum Aneuploidy Screen and Adverse Pregnancy Outcomes

Godbole

Kulkarni

Kanade

et al. 2016

J Obstet Gynecol India

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Objective To find out whether maternal serum screening for fetal chromosomal aneuploidy predicts adverse pregnancy outcomes. Methods A two-year retrospective case-control study was conducted at a tertiary hospital. Pregnant women with a high-risk serum screen but with chromosomally normal fetuses (n = 189) were compared to those with low-risk screen (controls, n = 157) for adverse pregnancy outcomes. p \ 0.005) and gestational age (R 2 = 4.9 %, b ± SE = 0.613 ± 0.296; p \ 0.05). Beta hCG in first and hCG in second trimester predicted oligohydramnios (R 2 = 9.2 %, b ± SE = -0.077 ± 0.025; p \ 0.005). The areas under the ROC curves of PAPP-A for LBW and PT were 0.70(p \ 0.01) and 0.684 (p \ 0.05), respectively. Conclusion A ''high-risk'' maternal serum screen with abnormal PAPP-A and/or beta hCG/HCG is associated with adverse pregnancy outcomes and may help identifying women requiring additional fetal surveillance.

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“…Appendix 5, Table 79 summarises each study's salient features. [153][154][155][156][157][158][159][160][161][162][163][164][165][166][167][168][169][170][171] One citation contributed to two separate studies and results. 156 The most common gestation tested was the mid-trimester (14-28 weeks commonly reported their results were 2.0 and 2.5 multiples of the median (MoMs).…”

Section: Study Characteristics and Qualitymentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

2010

Clinical Governance: An International Journal

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Second trimester total human chorionic gonadotropin, alpha-fetoprotein and unconjugated estriol in predicting pregnancy complications other than fetal aneuploidy

Cited by 49 publications

References 22 publications

Second trimester serum alpha-fetoprotein level is a significant positive predictor for intrauterine growth restriction in pregnant women with hyperemesis gravidarum

Second trimester serum alpha-fetoprotein level is a significant positive predictor for intrauterine growth restriction in pregnant women with hyperemesis gravidarum

Maternal Serum Aneuploidy Screen and Adverse Pregnancy Outcomes

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

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