Second-Trimester Placental Volumes Predict Birth Weight at Term

Clapp, James F.; Rizk, K.; Appleby-Wineberg, S.; Crass, Jeffrey R.

doi:10.1177/107155769500200104

Cited by 20 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although other studies have examined the effect of placental volume on birth weight (Wolf et al, 1989;Clapp et al, 1995;Thame et al, 2001), this study contributes important information on the effect of placental volume as well as the rate of placental growth in early pregnancy on fetal size (Clapp et al, 2000(Clapp et al, , 2002. Placental volume at 14 weeks gestation showed a significant positive association with all fetal measurements.…”

Section: Discussionmentioning

confidence: 80%

“…Traditionally, placental weight is measured at birth and the relationship of placental weight to birth weight has been used to indicate adequacy of fetal nutrition. However, there is limited information on the relationship between intrauterine placental volume and birth weight (Wolf et al, 1989;Clapp et al, 1995;Kinare et al, 2000;Thame et al, 2001). Although placental weight at delivery may be an important determinant of birth weight, both the pattern and rate of growth of the placenta throughout pregnancy are expected to be important contributors.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fetal growth is directly related to maternal anthropometry and placental volume

et al. 2004

View full text Add to dashboard Cite

Objective: To describe the influence of maternal weight and weight gain, placental volume and the rate of placental growth in early pregnancy on fetal dimensions measured sonographically. Design: In a prospective study, 712 women were recruited from the antenatal clinic of the University Hospital of the West Indies. Data analysis was confined to 374 women on whom measurements of the placental volume at 14, 17 and 20 weeks gestation were complete. Measurements of maternal anthropometry and fetal size (by ultrasound) were performed. Weight gain in pregnancy between the first antenatal visit (8-10 weeks) and 20 weeks gestation, and the rate of growth of the placenta between 14-17 and 17-20 weeks gestation were calculated. Main outcome measures: Fetal anthropometry (abdominal and head circumferences, femoral length, and biparietal diameter) at 35 weeks gestation. Results: Lower maternal weight at the first antenatal visit was associated with a significantly smaller placental volume at 17 and 20 weeks gestation (Po0.002 and o0.0001 respectively). In all women, maternal weight gain was directly related to fetal anthropometry. Placental volume at 14 weeks gestation and the rate of growth of the placenta between 17 and 20 weeks gestation were significantly related to all four fetal measurements. Conclusion: This study has provided evidence that both placental volume, and the rate of placental growth may influence fetal size. These effects are evident in the first half of pregnancy, and appear to be mediated through maternal weight and weight gain. Sponsorship: This study was supported by a grant from the Wellcome Trust,

show abstract

Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Fetal growth is directly related to maternal anthropometry and placental volume

et al. 2004

View full text Add to dashboard Cite

show abstract

“…As the expression of the markers in placental tissues was not affected by birth weight centile, any difference in plasma mRNA values could be due to the amount of mRNA released into the circulation. For example, it has been reported that the placental size bore a positive correlation with birth weight (Thomson et al, 1969;Molteni et al, 1978;Clapp et al, 1995;Thame et al, 2004). Since the markers we evaluated were placental derived (Ng et al, 2003b), their concentrations in maternal plasma might reflect the placental size and/or birth weight.…”

Section: Discussionmentioning

confidence: 99%

A strategy for identifying circulating placental RNA markers for fetal growth assessment

et al. 2009

View full text Add to dashboard Cite

Objective To evaluate whether circulating placental mRNAs in maternal plasma could serve as markers for the assessment of fetal growth or intrauterine growth restriction (IUGR).Methods From a panel of placental transcripts detectable in maternal plasma identified by microarray previously, we chose growth-related transcripts, namely CSH1, GH2, KISS1, and ADAM12, as potential growth markers. Relationships between the maternal plasma mRNA concentrations with several fetal growth indicators were studied. Maternal plasma mRNA concentrations from IUGR pregnancies with or without pre-eclampsia (PET) were compared with gestational age matched controls cross-sectionally and longitudinally. The four transcripts were quantified by one-step real-time RT-PCR.Results Maternal plasma GH2 mRNA significantly correlated with birth weight and fetal biometric measurements. Maternal plasma ADAM12 mRNA concentration was significantly higher in IUGR with PET than normal pregnancies in the cross-sectional comparison. No significant difference was observed for all markers between IUGR without PET and controls in both the cross-sectional and longitudinal comparisons. ConclusionThis study presents a potential strategy in identifying surrogate markers for the study of fetal growth. Circulating GH2 mRNA in maternal plasma appeared to be associated with fetal growth. The utility of this strategy and the currently assessed markers could be explored in further studies.

show abstract

“…37 Ultrasound assessment of placental volume as a surrogate for both placental and fetal weight may have the potential to identify some babies at risk of cerebral damage or antepartum death. 38,39 The association of established damage with low placental weight suggests that such damage may be averted or curtailed if placental disease could be recognised early.…”

Section: Neuropathologymentioning

confidence: 99%

The Scottish Perinatal Neuropathology Study—clinicopathological correlation in stillbirths

Becher

Bell

et al. 2006

BJOG

View full text Add to dashboard Cite

Objective To examine the neuropathology of fetuses dying before birth, to determine the timing of any brain damage seen and to ascertain clinical associations of pre-existing brain damage.Design Population-based observational study.Setting All 22 delivery units within Scotland, 1995Scotland, -1998 Sample All stillborn fetuses ‡24 weeks of gestation excluding those with chromosomal abnormality or central nervous system/cardiothoracic malformation.Methods Clinical detail was collected on all stillborn fetuses. Requests for postmortem included separate request for detailed neuropathological examination. Stillborn fetuses were classified as full term antepartum (normal growth/growth restricted), preterm antepartum (normal growth/growth restricted), intrapartum (full term/preterm), multiple births and stillborn fetuses following abruptions. Clinicopathological correlation attempted to define the timing of brain insult. Placentas were examined for each case where available.Main outcome measures Presence of established and/or recent brain damage.Results Clinical details were available for 471 stillborn fetuses, and detailed neuropathology was possible in 191 cases. Of these 191, 13 were multiple births, 9 died following abruption, 12 were intrapartum deaths and 157 were antepartum stillborn fetuses (99 preterm and 58 full term). Recent or established brain damage was seen in 66% of the entire cohort. Thirty-five percent of all cases showed well-established hypoxic damage predating the last evidence of fetal life, and this was more common in preterm fetuses (P = 0.015), those fetuses with evidence of recent damage (P < 0.001), in pregnancies complicated by pregnancy-induced hypertension (P = 0.044) and those in whom the placenta was <10th centile (P = 0.002).Conclusions Brain damage is commonly seen in stillborn infants, and in around one-third of cases, damage predates the period immediately before death. Factors suggesting suboptimal placental function are associated with such damage. Early identification of placental impairment may lead to improved pregnancy outcome.

show abstract

Second-Trimester Placental Volumes Predict Birth Weight at Term

Abstract: Second-trimester placental volumes and growth rates are good predictors of size at birth in healthy, active women. We speculate that this technique may have real value as an early screening tool to identify cases at risk of anomalous third-trimester growth.

Cited by 20 publications

References 13 publications

Fetal growth is directly related to maternal anthropometry and placental volume

Fetal growth is directly related to maternal anthropometry and placental volume

A strategy for identifying circulating placental RNA markers for fetal growth assessment

The Scottish Perinatal Neuropathology Study—clinicopathological correlation in stillbirths

Contact Info

Product

Resources

About