Second-trimester echogenic bowel and intraamniotic bleeding: Association between fetal bowel echogenicity and amniotic fluid spectrophotometry at 410 nm

Sepúlveda, Waldo; Reid, Rosemary; Nicolaidis, Peter; Prendiville, Oonagh; Chapman, Richard; Fisk, Nicholas M.

doi:10.1016/s0002-9378(96)70310-1

Cited by 50 publications

(21 citation statements)

References 15 publications

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“…79,80 An increased risk of IUGR, fetal death, and placenta-related complications is also recognized as being associated with hyperechoic bowel. 81 Despite its subjectivity, the prevalence of hyperechoic bowel among normal fetuses (0.5%) has been remarkably consistent at our center in the last decade and is also similar to that in other reports, suggesting that different centers can agree on the presence of hyperechoic bowel. We use a grading system for hyperechoic bowel, with grade 1 being mildly echogenic and typically diffuse, grade 2 being moderately echogenic and typically focal, and grade 3 being very echogenic, similar to that of bone structures.…”

Section: Hyperechoic Bowelsupporting

confidence: 90%

Sonographic markers of fetal trisomies: second trimester.

Nyberg

Souter

2001

J of Ultrasound Medicine

112

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Objective. Second-trimester sonographic findings of fetal trisomy may include structural abnormalities or sonographic markers of fetal aneuploidy. Unlike structural anomalies, sonographic markers of fetal aneuploidy are insignificant by themselves with regard to outcome, are nonspecific-most frequently seen in normal fetuses, and are often transient. Our objective was to review the secondtrimester sonographic findings of the major trisomic conditions, trisomies 13, 18, and 21. Methods. We reviewed a number of the most commonly accepted markers, including nuchal thickening, hyperechoic bowel, echogenic intracardiac focus, renal pyelectasis, shortened extremities, mild cerebral ventricular dilatation, and choroid plexus cysts. Markers associated with trisomy 21 were emphasized. Results. The sensitivity of sonography for detection of fetal trisomic conditions varies with the type of chromosome abnormality, gestational age at the time of sonography, reasons for referral, criteria for positive sonographic findings, and the quality of the sonography. As an estimate, 1 or more sonographic findings can be identified in approximately 90% of fetuses with trisomy 13, 80% of fetuses with trisomy 18, and 50% to 70% of fetuses with trisomy 21 (Down syndrome). Conclusions. The presence or absence of sonographic markers can substantially modify the risk of fetal Down syndrome and is the basis of the so-called genetic sonogram. Because maternal biochemical and sonographic markers are largely independent, combined risk estimates will result in even higher detection rates than either alone.

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Section: Hyperechoic Bowelsupporting

confidence: 90%

Sonographic markers of fetal trisomies: second trimester.

Nyberg

Souter

2001

J of Ultrasound Medicine

112

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“…The pathophysiology of increased bowel echogenicity is likely heterogeneous in nature. Blood, which is extremely echogenic, was reported in the fetal bowel, which could be due to fetal swallowing [Sepulveda et al, 1996] or as a consequence of possible intraluminal bleeding from the thrombocytopenia induced by infection (e.g., by cytomegalovirus, CMV) [Muller et al, 1995;Carlson et al, 2010]. Thus, in these patients, the hyperechogenic bowel was likely associated with intraluminal bleeding caused by thrombocytopenia.…”

Section: Discussionmentioning

confidence: 98%

SNP array and phenotype correlation shows that FLI1 deletion per se is not responsible for thrombocytopenia development in Jacobsen syndrome

Trková

Bečvářová

Hynek

et al. 2012

American J of Med Genetics Pt A

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Jacobsen syndrome (JBS) is a rare chromosomal disorder caused by terminal deletion of the long arm of chromosome 11. We report on four prenatally diagnosed patients with JBS with variable prenatal and postnatal phenotypes and 11q deletions of varying sizes. Precise characterization of the deleted region in three patients was performed by SNP arrays. The severity of both the prenatal and postnatal phenotypes did not correlate with the size of the haploinsufficient region. Despite the large difference in the deletion size (nearly 6 Mb), both of the live-born patients had similar phenotypes corresponding to JBS. However, one of the most prominent features of JBS, thrombocytopenia, was only present in the live-born boy. The girl, who had a significantly longer deletion spanning all four genes suspected of being causative of JBS-related thrombocytopenia (FLI1, ETS1, NFRKB, and JAM3), did not manifest a platelet phenotype. Therefore, our findings do not support the traditional view of deletion size correlation in JBS or the causative role of FLI1, ETS1, NFRKB, and JAM3 deletion per se for the development of disease-related thrombocytopenia.

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“…It has also been observed in women with intra-amniotic bleeding [10,11] , subchorionic hematoma [12] , and prenatal diagnosis of anencephaly [13,14] . In the third trimester of pregnancy, free-floating particulate matter has been attributed to the presence of vernix and meconium [15][16][17][18] and is present in about 88% by 35 weeks [19] .…”

Section: Discussionmentioning

confidence: 99%

Risk of Impending Preterm Delivery Associated with the Presence of Amniotic Fluid Sludge in Women in Preterm Labor with Intact Membranes

et al. 2011

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Objective: To determine the association of amniotic fluid sludge with impending preterm delivery in women in preterm labor with intact membranes. Methods: This was a retrospective cohort study in women at 22–34 weeks’ gestation in preterm labor with intact fetal membranes between February 2008 and May 2009. 16 women with amniotic sludge were identified. Each case of amniotic sludge was matched with 3 randomly selected controls. The primary outcome was delivery within 48 h of examination. Results: Mean cervical length was shorter in women with sludge than women without sludge (20.5 ± 9.0 vs. 27.9 ± 6.9 mm, p = 0.0016). There was a significant difference in the mean ultrasound-to-delivery interval in women with and without sludge (21.7 vs. 49.4 days, p = 0.006). Logistic regression analyses demonstrated that amniotic fluid sludge is a strong independent predictor of impending preterm delivery within 48 h (OR 11.2, 95% CI 1.2–125.9), 7 days (OR 3.8, 95% CI 1.2–17.3) and 14 days (OR 7.5, 95% CI 1.8–30.4). Conclusions: Amniotic fluid sludge on ultrasound scan is associated with impending preterm delivery in women in preterm labor with intact membranes.

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Second-trimester echogenic bowel and intraamniotic bleeding: Association between fetal bowel echogenicity and amniotic fluid spectrophotometry at 410 nm

Cited by 50 publications

References 15 publications

Sonographic markers of fetal trisomies: second trimester.

Sonographic markers of fetal trisomies: second trimester.

SNP array and phenotype correlation shows that FLI1 deletion per se is not responsible for thrombocytopenia development in Jacobsen syndrome

Risk of Impending Preterm Delivery Associated with the Presence of Amniotic Fluid Sludge in Women in Preterm Labor with Intact Membranes

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