Second-trimester amniotic fluid interleukin-10 concentration predicts preterm delivery

Apuzzio, Joseph J.; Chan, Ying; Al-Khan, Anthony; Illsley, Nicholas P.; Kim, Pei Lin; Vonhaggen, S.

doi:10.1080/14767050410001702186

Cited by 26 publications

(15 citation statements)

References 19 publications

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“…Hence, these decreasing concentrations could be related to a change in the Th1 profile [4,37,38] . Despite other reports indicating a negative correlation between amniotic fluid IL-10 concentrations and gestational age at delivery [39] , our findings did not reveal such an association in serum samples. It is necessary to emphasize that further research is still required to address the biological activity of the IL-10 family of cytokines during pregnancy and labor, as well as to identify its paracrine actions within the myometrium.…”

Section: Discussioncontrasting

confidence: 56%

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor

Reyes-Lagos

Peña-Castillo

Pérez‐Sánchez³

et al. 2017

Neuroimmunomodulation

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Labor is regarded as increased myometrial activity with a regular contractility pattern. At this final stage of pregnancy, myometrial quiescence is lost, accompanied by altered immune homeostasis. It is well known that the interleukin (IL)-10 family of cytokines modulates immunological responses mainly in epithelial cells, including the endometrium. To investigate their inflammatory profile during labor, we performed a longitudinal study in a group of healthy pregnant women (n = 20) with uncomplicated pregnancies in the third trimester of pregnancy and during active labor. Blood was sampled from pregnant women in the third trimester (gestational age 32-38 weeks, mean 36 ± 2 weeks) and during active labor (39-41 weeks of gestation, mean 40 ± 1 weeks). Serum levels of several cytokines were measured using multiplex immunoassays for both stages, indicating that the concentrations of IL-10, IL-20, IL-22, IL-28A, and interferon (IFN)-γ were significantly decreased during active labor in comparison with third-trimester levels (p < 0.05). Our analysis did not find significant correlations between IL-10, IL-20, IL-22, IL-28A, and IFN-γ levels and gestational age. However, our data suggest that the systemic downregulation of several members of the IL-10 family of cytokines plays an important role in the activation of myometrial smooth cells associated with uterine contractions during active labor. Downregulation of this IL-10 family of cytokines seems to coincide with the well-reported functional progesterone withdrawal during labor. Likewise, lower plasma IFN-γ concentrations may indicate a role for IFN-γ in active labor.

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Section: Discussioncontrasting

confidence: 56%

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor

Reyes-Lagos

Peña-Castillo

Pérez‐Sánchez³

et al. 2017

Neuroimmunomodulation

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“…Apuzzio et al [177], in contrast to our findings, have previously reported higher concentrations of both IL-10 and IL-6 in second trimester amniotic fluid from patients who subsequently delivered preterm, as well as an inverse correlation between amniotic fluid IL-10 concentration at the time of mid-trimester genetic amniocentesis and gestational age at delivery [177].…”

Section: Amniotic Fluid Il-10 In the Mid-trimestercontrasting

confidence: 56%

The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: A role for interleukin-10

Gotsch

Romero

Kusanovic

et al. 2008

The Journal of Maternal-Fetal & Neonatal Medicine

119

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Objective. The anti-inflammatory limb of the immune response is crucial for dampening inflammation. Spontaneous parturition at term and preterm labor (PTL) are mediated by inflammation in the cervix, membranes, and myometrium. This study focuses on the changes in the amniotic fluid concentrations of the anti-inflammatory cytokine interleukin (IL)-10. The objectives of this study were to determine whether there is a relationship between amniotic fluid concentrations of IL-10 and gestational age, parturition (at term and preterm), and intra-amniotic infection/inflammation (IAI). Study design. A cross-sectional study was conducted including 301 pregnant women in the following groups: (1) midtrimester of pregnancy who delivered at term (n ¼ 112); (2) mid-trimester who delivered preterm neonates (n ¼ 30); (3) term not in labor without IAI (n ¼ 40); (4) term in labor without IAI (n ¼ 24); (5) term in labor with IAI (n ¼ 20); (6) PTL without IAI who delivered at term (n ¼ 31); (7) PTL without IAI who delivered preterm (n ¼ 30); (8) PTL with IAI who delivered preterm (n ¼ 14). IL-10 concentrations in amniotic fluid were determined by a specific and sensitive immunoassay. Nonparametric statistics were used for analysis. Results.(1) IL-10 was detectable in amniotic fluid and its median concentration did not change with gestational age from mid-trimester to term. (2) Patients in labor at term had a significantly higher median amniotic fluid IL-10 concentration than that of patients at term not in labor (p ¼ 0.04). (3) Women at term in labor with IAI had a significantly higher median amniotic fluid IL-10 concentration than that of patients at term in labor without IAI (p ¼ 0.02). (4) Women with PTL and IAI who delivered preterm had a significantly higher median amniotic fluid concentration of IL-10 than those without IAI who delivered preterm and than those who delivered at term (p ¼ 0.009 and p 5 0.001, respectively). (5) Among patients with preterm labor without IAI, those who delivered preterm had a significantly higher median amniotic fluid IL-10 concentration than those who delivered at term (p ¼ 0.03). Conclusions. The anti-inflammatory cytokine IL-10 is detectable in the amniotic fluid of normal pregnant women. Spontaneous parturition at term and in preterm gestation is associated with increased amniotic fluid concentrations of IL-10. IAI (preterm and at term) is also associated with increased amniotic fluid concentrations of IL-10. We propose that IL-10 has a role in the regulation of the immune response in vivo by initiating actions that dampen inflammation.

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“…High IL-10 was a statistically significant predictor of future PTB at all 3 cutoff levels tested, though this cytokine was detectable in only about half of the serum samples and it was not among the risk factors in our more comprehensive model. As an immunosuppressive cytokine, IL-10 attenuates production of proinflammatory cytokines and has been theorized as an anti-parturition mediator [7] . However, in concert with our findings, Apuzzio et al [7] found elevated IL-10 in second trimester amniotic fluid of women who later delivered preterm.…”

Section: Discussionmentioning

confidence: 99%

“…As an immunosuppressive cytokine, IL-10 attenuates production of proinflammatory cytokines and has been theorized as an anti-parturition mediator [7] . However, in concert with our findings, Apuzzio et al [7] found elevated IL-10 in second trimester amniotic fluid of women who later delivered preterm.…”

Section: Discussionmentioning

confidence: 99%

Interrelationship of Cytokines, Hypothalamic-Pituitary-Adrenal Axis Hormones, and Psychosocial Variables in the Prediction of Preterm Birth

Pearce

Grove²,

Bonney³

et al. 2010

Gynecol Obstet Invest

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Background/Aims: To examine the relationship of biological mediators (cytokines, stress hormones), psychosocial, obstetric history, and demographic factors in the early prediction of preterm birth (PTB) using a comprehensive logistic regression model incorporating diverse risk factors. Methods: In this prospective case-control study, maternal serum biomarkers were quantified at 9–23 weeks’ gestation in 60 women delivering at <37 weeks compared to 123 women delivering at term. Biomarker data were combined with maternal sociodemographic factors and stress data into regression models encompassing 22 preterm risk factors and 1st-order interactions. Results: Among individual biomarkers, we found that macrophage migration inhibitory factor (MIF), interleukin-10, C-reactive protein (CRP), and tumor necrosis factor-α were statistically significant predictors of PTB at all cutoff levels tested (75th, 85th, and 90th percentiles). We fit multifactor models for PTB prediction at each biomarker cutoff. Our best models revealed that MIF, CRP, risk-taking behavior, and low educational attainment were consistent predictors of PTB at all biomarker cutoffs. The 75th percentile cutoff yielded the best predicting model with an area under the ROC curve of 0.808 (95% CI 0.743–0.874). Conclusion: Our comprehensive models highlight the prominence of behavioral risk factors for PTB and point to MIF as a possible psychobiological mediator.

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Second-trimester amniotic fluid interleukin-10 concentration predicts preterm delivery

Cited by 26 publications

References 19 publications

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor

The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: A role for interleukin-10

Interrelationship of Cytokines, Hypothalamic-Pituitary-Adrenal Axis Hormones, and Psychosocial Variables in the Prediction of Preterm Birth

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Second-trimester amniotic fluid interleukin-10 concentration predicts preterm delivery

Cited by 26 publications

References 19 publications

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-&#x03B3; Decrease from the Third Trimester of Pregnancy to Active Labor

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-&#x03B3; Decrease from the Third Trimester of Pregnancy to Active Labor

The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: A role for interleukin-10

Interrelationship of Cytokines, Hypothalamic-Pituitary-Adrenal Axis Hormones, and Psychosocial Variables in the Prediction of Preterm Birth

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Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor

Women Serum Concentrations of the IL-10 Family of Cytokines and IFN-γ Decrease from the Third Trimester of Pregnancy to Active Labor