Second to fourth digit ratio in female patients with acne vulgaris: Could it be a predictor of androgen receptor status?

Farag, Azza Gaber Antar; Shoiab, Mohamed Ahmed; Samaka, Rehab Monir; Abdou, Asmaa Gaber; Elnaidany, Nada Farag; Mansour, Asmhan Omar M.

doi:10.4103/ijdvl.ijdvl_35_18

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…The risk of developing psoriasis in first degree relatives of patients with type-1 psoriasis and early onset and higher familial predisposition is approximately five times higher than that in patients with type-2 psoriasis. 24,25 Although no difference was observed in females with psoriasis in our study, male patients with type-2 psoriasis had a higher 2D:4D ratio than male patients with type-1 psoriasis.…”

Section: Discussioncontrasting

confidence: 71%

Is prenatal testosterone‐estrogen balance associated with psoriasis?

Özer

Temiz

Ataseven

et al. 2020

Dermatologic Therapy

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The etiopathogenesis of psoriasis is not understood; however, psoriasis is affected by hormones, particularly the sex steroids. The second-to-fourth digit (2D:4D) ratio, which is an indicator of prenatal sex hormone balance, has been studied in various diseases that are affected by hormones. A total of 369 individuals comprising 172 patients with psoriasis and 197 healthy volunteers were included in the study.

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Section: Discussioncontrasting

confidence: 71%

Is prenatal testosterone‐estrogen balance associated with psoriasis?

Özer

Temiz

Ataseven

et al. 2020

Dermatologic Therapy

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show abstract

“…This has been suggested to reflect prenatal androgen exposure and sensitivity and shows an inverse correlation with prenatal testosterone levels. This ratio was found to be significantly lower in female acne patients aged between 16 and 36 years compared with healthy controls, and associated with upregulated cutaneous AR [50]. This should be investigated in children with neonatal or infantile acne.…”

Section: Androgens and Acnementioning

confidence: 99%

Sex hormones and acne: State of the art

Hu¹,

Wei

Qiang

et al. 2021

J Deutsche Derma Gesell

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Summary Acne is an androgen‐dependent inflammatory disease of sebaceous follicles. Herein, we reviewed and discussed the underlying pathways of androgen biosynthesis and metabolism, non‐genomic regulation of androgen receptor expression and function, posttranslational regulation of androgen excess in acne and acne‐associated syndromes, such as polycystic ovary syndrome, and congenital adrenal hyperplasia. We provide insights into the involvement of sex hormones, particularly androgens, in skin homeostasis and acne pathogenesis, including comedogenesis, lipogenesis, microbiota, and inflammation. Advanced understanding of the action mechanisms of classical acne treatment and new development of antiandrogens, both topical and systemic, are also highlighted.

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“…Es wird angenommen, dass dies mit der pränatalen Exposition und Sensitivität gegenüber Androgenen korreliert; es zeigt sich eine inverse Korrelation der 2D:4D-Ratio mit pränatalen Testosteronspiegeln. Bei Akne-Patientinnen zwischen 16 und 36 Jahren lag dieses Verhältnis signifikant niedriger als bei gesunden Kontrollpersonen und war mit einem hochregulierten AR assoziiert [50]. Bei Kindern mit neonataler oder frühkindlicher Akne sollte dies untersucht werden.…”

Section: Androgene Und Akneunclassified

Sexualhormone und Akne: Aktueller Stand

Hu¹,

Wei²,

Qiang³

et al. 2021

J Deutsche Derma Gesell

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Zusammenfassung Akne ist eine androgenabhängige entzündliche Erkrankung der Talgdrüsen. Diese Studie beschäftigt sich mit den zugrundeliegenden Signalwegen der Androgen‐Biosynthese und des Androgen‐Metabolismus, mit der nicht‐genomischen Regulation der Androgenrezeptor‐Expression und –Funktion sowie mit der post‐translationalen Regulation des Androgenüberschusses bei Akne und akne‐assoziierten Syndromen. Zu diesen zählen beispielsweise das Syndrom der polyzystischen Ovarien (PCOS, polycystic ovary syndrome) und die kongenitale Nebennierenhyperplasie. Neue Erkenntnisse zur Rolle der Sexualhormone – insbesondere der Androgene – für die Homöostase der Haut und die Pathogenese der Akne werden diskutiert, einschließlich Komedogenese, Lipogenese, Mikrobiom und Entzündung. Die Wirkmechanismen klassischer Akne‐Therapeutika werden vorgestellt, ebenso neu entwickelte topische und systemische Antiandrogene.

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Second to fourth digit ratio in female patients with acne vulgaris: Could it be a predictor of androgen receptor status?

Cited by 4 publications

References 2 publications

Is prenatal testosterone‐estrogen balance associated with psoriasis?

Is prenatal testosterone‐estrogen balance associated with psoriasis?

Sex hormones and acne: State of the art

Sexualhormone und Akne: Aktueller Stand

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