Second Primary Tumours in Head and Neck Cancer

González‐Botas, Jesús Herranz; Varela-Vázquez, Patricia; Barro, Carlos Vázquez

doi:10.1016/j.otoeng.2016.04.005

Cited by 7 publications

(7 citation statements)

References 32 publications

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“…There is a large discrepancy between the prevalence of esophageal-SPTs in patients with HNSCC found with Lugol chromoendoscopy screening (15%, 95% CI: [11][12][13][14][15][16][17][18][19] and the prevalence of retrospective non-screening studies (1%-6%). 6,7,[49][50][51][52][53] This was also noted by Wang, Lee, et al 31 This discrepancy could indicate that without an active screening program, esophageal-SPTs are underdiagnosed in patients with HNSCC. 7 Multiple studies state that the occurrence of esophageal-SPTs negatively influences patient survival, especially in patients with advanced esophageal-SPTs.…”

Section: Discussionmentioning

confidence: 90%

“…There is a large discrepancy between the prevalence of esophageal‐SPTs in patients with HNSCC found with Lugol chromoendoscopy screening (15%, 95% CI: 11‐19) and the prevalence of retrospective non‐screening studies (1%‐6%) . This was also noted by Wang, Lee, et al This discrepancy could indicate that without an active screening program, esophageal‐SPTs are underdiagnosed in patients with HNSCC .…”

Section: Discussionmentioning

confidence: 95%

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Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

et al. 2018

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Background Early detection of esophageal secondary primary tumors (SPTs) in head and neck squamous cell carcinoma (HNSCC) patients could increase patient survival. The purpose of this study was to determine the diagnostic yield of esophageal SPTs using Lugol chromoendoscopy. Methods A systematic review of all available databases was performed to find all Lugol chromoendoscopy screening studies. Results Fifteen studies with a total of 3386 patients were included. The average yield of esophageal‐SPTs in patients with HNSCC was 15%. The prevalence was the highest for patients with an index hypopharyngeal (28%) or oropharyngeal (14%) tumor. The esophageal‐SPTs were classified as high‐grade dysplasia in 49% of the cases and as invasive carcinoma's in 51%. Conclusion Our results show that 15% of the patients with HNSCC that underwent Lugol chromoendoscopy were diagnosed with an esophageal‐SPT. Based on these results there is enough evidence to perform Lugol chromoendoscopy, especially in an Asian patient population.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 95%

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

et al. 2018

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“…Especially for the case of extensive and/or numerous lesions, the decision on the location and size of the tissue sample for a representative biopsy is challenging [ 9 , 10 ]. Moreover, missing out on recurrences and relapses (second primary cancer) or redundant biopsies is problematic [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Endoscopic Optical Coherence Tomography of the Healthy Human Oral Mucosa: Qualitative and Quantitative Image Analysis

Albrecht¹,

Schnabel

Mueller

et al. 2020

Diagnostics

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To date, there is still a lack of reliable imaging modalities to improve the quality of consultation, diagnostic and medical examinations of the oral mucosa in dentistry. Even though, optical technologies have become an important element for the detection and treatment of different diseases of soft tissue, for the case of oral screenings the evidence of the benefit in comparison to conventional histopathology is mostly still pending. One promising optical technology for oral diagnostics is optical coherence tomography (OCT). To prove the potential of OCT, even the amount of freely accessible OCT data is not sufficient to describe the variance of healthy human oral soft tissue in vivo. In order to remedy this deficiency, the present study provides in vivo OCT cross sections of the human oral mucosa of the anterior and posterior oral cavity as well as the oropharynx of 47 adult volunteers. A collection of representative OCT cross sections forms the basis for a randomized blinded image analysis by means of seven criteria to assess the main features of the superficial layers of the human oral mucosa and to determine its correlation to regional features known from hematoxylin and eosin (HE) stained histology.

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“…Head and neck cancer (HNC) is the most frequent primitive cancer associated with lung cancer (14,15). It may be synchronous or metachronous.…”

Section: Introductionmentioning

confidence: 99%

“…It may be synchronous or metachronous. The most frequent second malignant tumor among patients previously treated for HNC is lung cancer (14). Swallowing disorders are common after HNC treatment and are reported in up to 88% of patients depending on the tumor location, tumor size, and treatment (16,17).…”

Section: Introductionmentioning

confidence: 99%

Impact of previous head and neck cancer on postoperative complications after surgical resection for lung cancer: a case-control study

et al. 2018

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Second Primary Tumours in Head and Neck Cancer

Cited by 7 publications

References 32 publications

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

In Vivo Endoscopic Optical Coherence Tomography of the Healthy Human Oral Mucosa: Qualitative and Quantitative Image Analysis

Impact of previous head and neck cancer on postoperative complications after surgical resection for lung cancer: a case-control study

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