Second Primary Digestive Cancer After Resection of Lung Cancer

Kamiyama, Hidenori; Ikeya, Tomohiko; Suda, Kazuharu; Murai, Katsumi; Aoyama, Katsuhiko; Hoshi, Eishin

doi:10.1007/s00595-004-2762-0

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…The incidence of a second primary digestive cancer following resection of lung cancer has been reported to be 1-2% (24). The proportion of patients successfully treated for their initial non-small cell lung carcinoma and at risk of developing a second non-small cell lung carcinoma has been reported to be 1-2% (25,26).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological features and the impact of the new TNM classification of malignant tumors in patients with pulmonary large cell neuroendocrine carcinoma

Iyoda

Jiang

Travis

et al. 2013

Molecular and Clinical Oncology

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Abstract.The prognosis of patients with large-cell neuroendocrine carcinoma (LCNEC) of the lung is extremely poor and the optimal treatment for these patients has yet to be determined. In this study, we described the clinicopathological characteristics of LCNECs and compared the prognoses of corresponding stages determined by the guidelines of the 6th and 7th editions of the TNM classification of malignant tumors. Clinical data from 42 patients diagnosed with primary LCNEC who underwent treatment at Kitasato University Hospital between 1991 and 2009 were retrospectively analyzed. On follow-up of 42 patients, 22 (52.4%) had confirmed recurrent tumors, including 8 patients with mediastinal lymph node recurrences and 19 with distant metastases. The sites of distant metastases included the brain in 8, bone in 8, liver in 7, lungs in 5 and adrenal glands in 4 patients. For all the patients, the 5-year overall survival rate was 34.7% and the 5-year disease-free survival rate was 32.9%. The 5-year overall survival rates of patients with stage I cancers according to the 6th and 7th staging editions was 51.3% (6th n=18, 7th n=16). Thirteen of 42 patients (31.0%) also had metachronous or synchronous primary cancers. Patients with LCNEC had poor outcomes, even those with stage I tumors classified according to the 7th edition of the TNM classification. Therefore, frequent recurrences in addition to metachronous or synchronous primary cancers in patients with LCNEC should be treated.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological features and the impact of the new TNM classification of malignant tumors in patients with pulmonary large cell neuroendocrine carcinoma

Iyoda

Jiang

Travis

et al. 2013

Molecular and Clinical Oncology

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“…The incidence of second primary digestive cancer after resection of lung cancer has been reported as 1% to 2%. 22 The number of patients successfully treated for their initial non-small cell lung carcinoma and at risk of developing a second non-small cell lung carcinoma has been reported as approximately 1% to 2%. 23,24 From this point of view, our results revealed a very high rate for developing a second primary cancer in patients with LCNEC, including 4 patients who had more than 1 tumor.…”

Section: Discussionmentioning

confidence: 99%

Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large-cell neuroendocrine carcinoma

Iyoda

Hiroshima

Moriya

et al. 2009

The Journal of Thoracic and Cardiovascular Surgery

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“…Most of gastric metastases are submucosal; thus, they generally remain asymptomatic [ 17 ]. On the other hand, lung cancer is primarily known to be associated with upper aerodigestive cancer [ 30 – 33 ] and lung cancer seems to be one of the most common second primary cancers in patients with GC [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Concurrent Tumors Revealed by an Autopsy-A Case Report and Literature Review

Cristian

Boşoteanu

Aşchie

et al. 2022

Case Reports in Gastrointestinal Medicine

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Introduction. Multiple primary malignant neoplasms are an uncommon phenomenon, given the very low incidence of two or more different tumors, while neoplasm may be limited to a single organ or may involve multiple separate anatomical organs. The main purpose of this study is to highlight the importance of morphological and immunohistochemical tests to distinguish the origin of the primary tumor. Case Presentation. We report the case of a 65-year-old deceased male, presenting multiple tumors in the lung, stomach, kidneys, and adrenal organs. The main symptoms presented by the patient were dyspnea with a range of 77% with oxygen saturation, fatigability, and productive cough. Histopathological examination revealed a solid and papillary lung adenocarcinoma, concurrent with tubular gastric adenocarcinoma. Immunohistochemical testing was mandatory by using a panel of seven monoclonal mouse antibodies (TTF-1, Napsin A, CK7, CK20, p40, synaptophysin, and chromogranin A). The pulmonary tumoral immunophenotype (positive for TTF-1, Napsin A, CK7; negative for CK20, p40, synaptophysin, and chromogranin A) confirms the diagnosis of primary lung ADC and invalidates the hypothesis of a metastasis arisen from a gastric adenocarcinoma or other forms of lung cancer. Conclusion. The importance of the ancillary test is to distinguish a primary tumor from a metastatic one.

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Second Primary Digestive Cancer After Resection of Lung Cancer

Abstract: Special attention must be paid to the possibility of SPDC after the resection of lung cancer to improve the prognosis of patients with lung cancer.

Cited by 4 publications

References 9 publications

Clinicopathological features and the impact of the new TNM classification of malignant tumors in patients with pulmonary large cell neuroendocrine carcinoma

Clinicopathological features and the impact of the new TNM classification of malignant tumors in patients with pulmonary large cell neuroendocrine carcinoma

Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large-cell neuroendocrine carcinoma

Concurrent Tumors Revealed by an Autopsy-A Case Report and Literature Review

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