Second Primary Cancers in Thyroid Cancer Patients: A Multinational Record Linkage Study

Sandeep, Thekkepat C.; Strachan, Mark W. J.; Reynolds, Rebecca M.; Brewster, David H.; Scélo, Ghislaine; Pukkala, Eero; Hemminki, Kari; Anderson, Aage; Tracey, Elizabeth; Friis, Søren; McBride, Mary L.; Ks, Chia; Pompe-Kirn, Vera; Kliewer, Erich V.; Tonita, Jon; Jonasson, Jón G.; Martos, Carmen; Boffetta, Paolo; Brennan, Paul

doi:10.1210/jc.2005-2009

“…Recently, Sandeep et al published a large multinational record linkage study on second primary cancers in thyroid cancer patients (21). The study was conducted at 13 population-based cancer registries in Europe, Canada, Australia, and Singapore and included a cohort of 39.002 patients with primary thyroid cancer.…”

Section: Discussionmentioning

confidence: 99%

The incidence of second primary tumors in thyroid cancer patients is increased, but not related to treatment of thyroid cancer

Verkooijen¹,

Smit²,

Romijn³

et al. 2006

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Objective: The aim of the present study is to assess the prevalence of second primary tumors in patients treated for thyroid cancer. Furthermore, we wanted to assess the standardized risk rates for all second primary tumors, but especially for breast cancer, as data in the literature indicate an excessive risk in differentiated thyroid cancer (DTC) patients for this tumor. Materials and methods: We included consecutive patients, who received ablation treatment with I-131 at the Leiden University Medical Center between January 1985 and December 1999 (nZ282). The mean period of follow-up was 10.6G4.1 years. Results: Thirty-five of the 282 patients (12.4%) had a second primary tumor (SPT), either preceding or following the diagnosis of thyroid cancer. Five other patients had three primary tumors, including DTC. As a result, 40 additional tumors were found in this group, revealing an overall prevalence of 14.2%. Twenty tumors (7.1%) preceded the thyroid cancer with a mean interval of 5.7 years (range: 0.5-22.0 years), whereas 20 tumors (7.1%) occurred after this tumor with a mean interval of 6.7 years (range: 1.0-15.0 years). In 13 female patients, breast cancer was found as SPT. The standardized incidence rate (SIR) for all cancers after the diagnosis of DTC in this study population was not increased (1.13; confidence interval (CI): 0.68-1.69). However, we found an increased SIR of 2.26 (CI: 1.60-3.03) for all cancers either following or preceding DTC, which is mainly caused by a SIR of 3.95 (CI: 2.06-6.45) for breast cancer. Conclusion: Patients with DTC have an overall increased standardized incidence rate for second primary tumors, but not for second primary tumors following I-131 therapy. These findings suggest a common etiologic and/or genetic mechanism instead of a causal relation.European Journal of Endocrinology 155 801-806

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“…Lymphatic metastasis from papillary thyroid cancer occurs to neck lateral nodal groups of levels II, III, IV and central (level VI) lymph nodes. Thyroid cancer patients have an increased risk of developing a second cancer as either synchronous or metachronous [4]. In a pooled analysis of primary carcinoma thyroid patients from 13 registries, Sandeep et al [4] found a 30% increase in risk of second cancers including salivary gland, kidney, prostate, skin, breast, brain, myeloma, leukemia, and non-Hodgkin lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Hypoxemia in minimally invasive esophagectomy for squamous cell carcinoma of lower esophagus

Lam¹,

Trung²

2017

IJCRI

0

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations.IJCRI publishes Review Articles, Case Series, Case Reports, Case in Images, Clinical Images and Letters to Editor. Website: www.ijcasereportsandimages.comSynchronous dual malignancy of papillary carcinoma thyroid and squamous cell carcinoma tongue: A case report Tej Prakash Soni, Sajal Goel, Lalit Mohan Sharma, Anil Kumar Gupta, Shantanu Sharma, Ravindra Gothwal ABSTRACT Introduction: Patients with thyroid carcinoma have increased risk for development of second malignancy either synchronous or metachronous. We are reporting a rare case of synchronous squamous cell carcinoma oral tongue and papillary thyroid carcinoma. Case Report: A 60-year-old smoker male was presented with the complaints of non-healing ulcer (2x2 cm) at right anterolateral tongue since six months. Excision biopsy of tongue ulcer was reported as pT 0.8x0.8 cm, moderately differentiated squamous cell carcinoma. Wide local excision of tongue lesion with right modified neck dissection was done. Histopathology was reported as no residual primary tongue tumor seen, 1 out of 28 lymph nodes showed metastatic deposits of squamous cell carcinoma. Unexpectedly another one lymph node was positive of metastatic thyroid papillary carcinoma. Total thyroidectomy with central compartment neck dissection and left modified neck dissection was done. Histopathology was reported as pT 2x1 cm, papillary carcinoma right lobe of thyroid, 7 out of 32 lymph nodes showed metatstatic paillary carcinoma thyroid. Although exact cause of second malignancy is unknown but field cancerization, genetic predisposition, history of prior radiation or chemotherapy, improved survival can be attributed for increased incidence of second cancer. Conclusion: Double malignancies require multidisciplinary management approach.

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“…Thyroid cancer patients have an increased risk of developing a second cancer as either synchronous or metachronous [4]. In a pooled analysis of primary carcinoma thyroid patients from 13 registries, Sandeep et al [4] found a 30% increase in risk of second cancers including salivary gland, kidney, prostate, skin, breast, brain, myeloma, leukemia, and non-Hodgkin lymphoma. On another side primary head neck cancer patients also have increased incidence (2-3% per year) of development of second primary cancer [5].…”

Section: Discussionmentioning

confidence: 99%

Synchronous dual malignancy of papillary carcinoma thyroid and squamous cell carcinoma tongue: A case report

Soni¹,

Goel²,

Sharma³

et al. 2017

IJCRI

0

View full text Add to dashboard Cite

International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations.IJCRI publishes Review Articles, Case Series, Case Reports, Case in Images, Clinical Images and Letters to Editor. Website: www.ijcasereportsandimages.comSynchronous dual malignancy of papillary carcinoma thyroid and squamous cell carcinoma tongue: A case report Tej Prakash Soni, Sajal Goel, Lalit Mohan Sharma, Anil Kumar Gupta, Shantanu Sharma, Ravindra Gothwal ABSTRACT Introduction: Patients with thyroid carcinoma have increased risk for development of second malignancy either synchronous or metachronous. We are reporting a rare case of synchronous squamous cell carcinoma oral tongue and papillary thyroid carcinoma. Case Report: A 60-year-old smoker male was presented with the complaints of non-healing ulcer (2x2 cm) at right anterolateral tongue since six months. Excision biopsy of tongue ulcer was reported as pT 0.8x0.8 cm, moderately differentiated squamous cell carcinoma. Wide local excision of tongue lesion with right modified neck dissection was done. Histopathology was reported as no residual primary tongue tumor seen, 1 out of 28 lymph nodes showed metastatic deposits of squamous cell carcinoma. Unexpectedly another one lymph node was positive of metastatic thyroid papillary carcinoma. Total thyroidectomy with central compartment neck dissection and left modified neck dissection was done. Histopathology was reported as pT 2x1 cm, papillary carcinoma right lobe of thyroid, 7 out of 32 lymph nodes showed metatstatic paillary carcinoma thyroid. Although exact cause of second malignancy is unknown but field cancerization, genetic predisposition, history of prior radiation or chemotherapy, improved survival can be attributed for increased incidence of second cancer. Conclusion: Double malignancies require multidisciplinary management approach.

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Second Primary Cancers in Thyroid Cancer Patients: A Multinational Record Linkage Study

Cited by 163 publications

References 28 publications

The incidence of second primary tumors in thyroid cancer patients is increased, but not related to treatment of thyroid cancer

The incidence of second primary tumors in thyroid cancer patients is increased, but not related to treatment of thyroid cancer

Hypoxemia in minimally invasive esophagectomy for squamous cell carcinoma of lower esophagus

Synchronous dual malignancy of papillary carcinoma thyroid and squamous cell carcinoma tongue: A case report

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