Second neoplasm in children treated in EORTC 58881 trial for acute lymphoblastic malignancies: Low incidence of CNS tumours

Abstract

The overall incidence rate of SN is comparable to that reported previously. In spite of short follow-up time, the low incidence of brain tumours might be related to the omission of cranial radiotherapy.

Acute Lymphoblastic Leukemia: What Have We Learned About the Effects of This Disease and Its Treatment on the Nervous System?

“…The use of intrathecal and systemic chemotherapy instead of cranial radiation has led to a reduced rate of secondary CNS tumors. The just-published results of the EORTC 58881 trial which did not include cranial radiotherapy showed a very low rate of secondary malignancies, with only one patient out of 2,261 enrolled being diagnosed with glioblastoma multiforme (Renard et al, 2011). Our own experience at the UC Irvine Chao Cancer Center and the Children Hospital of Orange County is that often the secondary meningiomas in ALL survivors are atypical or anaplastic (see figure 4).…”

The prognosis of osteosarcoma occurring as second malignancy of childhood cancers may be favorable: experience of two cancer centers in Japan

“…Retinoblastoma, malignant lymphoma, leukemia, melanoma, neuroblastoma, rhabdomyosarcoma, Ewing's sarcoma, malignant fibrous histiocytoma, Wilms' tumor, and adrenocortical carcinoma have been reported as the pathological diagnoses of first childhood cancers for osteosarcoma occurring as second malignancy [5,[11][12][13][14][15][16][17][18][19], but their clinical characteristics have not been clarified.…”

High-Grade Supraclavicular Soft Tissue Sarcoma as Secondary Malignancy After Successful Treatment of Acute Myeloid Leukemia: Case Report and Literature Review

“…5,9,17,19 Although this mainly involves carcinomas of the skin or mucosal tissues, 4,13,14 an increased risk of STS remains. 10,12 We report the present case of an unusual STS after curative therapy for acute myeloid leukemia (AML) because published data of secondary STSs are rare.…”

“…4,15,19 As intensified treatment protocols for hematopoetic malignancies have led to prolonged survival or even cure, the incidence of secondary malignancies has increased. 8,20 Although most secondary cancers are of the hematopoetic system, 10,11,13,[15][16][17] the risk of solid tumor occurrence is still elevated two-to sixfold. 5,9,17,19 Although this mainly involves carcinomas of the skin or mucosal tissues, 4,13,14 an increased risk of STS remains.…”

“…2,3 However, the risk of developing a STS is increased, just as for other cancers, as a secondary malignancy after local or total body irradiation, 4-8 chemotherapy, [9][10][11] immunosuppressive therapy, 4,5,[12][13][14][15] and bone marrow transplantation (BMT). 4,5,[8][9][10][11]14,16 Therefore, patients with hematopoetic system malignancies have an increased risk of secondary malignant tumors because their treatment regimen often involves all these treatment approaches to achieve a cure. 9,12,[15][16][17][18] Recent data suggest an association between graft-versus-host disease (GVHD) after BMT and the occurrence of secondary neoplasms.…”