Second messenger networks for accurate growth cone guidance

Akiyama, Hiroki; Kamiguchi, Hiroyuki

doi:10.1002/dneu.22157

Cited by 16 publications

(13 citation statements)

References 120 publications

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“…The mechanisms by which physiological levels of ROS support neurite outgrowth and axon specification appear to involve release of calcium from intracellular stores, a potent second messenger regulating cytoskeletal organisation and dynamics (reviewed in ). Short respiratory bursts of NADPH oxidase‐generated ROS promote calcium release by redox modification of ryanodine (RyRs) and inositol‐3‐phosphate receptors (IP3Rs).…”

Section: Regulation Of Ros In the Nervous System The Case For The Dementioning

confidence: 99%

Regulation of neuronal development and function by ROS

et al. 2018

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Reactive oxygen species (ROS) have long been studied as destructive agents in the context of nervous system ageing, disease and degeneration. Their roles as signalling molecules under normal physiological conditions is less well understood. Recent studies have provided ample evidence of ROS‐regulating neuronal development and function, from the establishment of neuronal polarity to growth cone pathfinding; from the regulation of connectivity and synaptic transmission to the tuning of neuronal networks. Appreciation of the varied processes that are subject to regulation by ROS might help us understand how changes in ROS metabolism and buffering could progressively impact on neuronal networks with age and disease.

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Section: Regulation Of Ros In the Nervous System The Case For The Dementioning

confidence: 99%

Regulation of neuronal development and function by ROS

et al. 2018

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“…; Tojima ; Dudanova & Klein ; Sutherland et al . ; Akiyama & Kamiguchi ). For example, an extracellular concentration gradient of a guidance cue evokes asymmetric Ca 2+ elevations across the inside of the growth cone, with higher Ca 2+ concentrations on the side facing the cue (Henley & Poo ; Henley et al .…”

Section: Introductionmentioning

confidence: 99%

“…The growth cone senses a variety of surrounding extracellular molecules such as trophic factors, guidance cues, and extracellular matrix (ECM) components (Tessier-Lavigne & Goodman 1996;O'Donnell et al 2009). These multiple extracellular signals are translated and integrated into intracellular second messenger networks to direct growth cone behaviors (Gomez & Zheng 2006;Tojima et al 2011;Tojima 2012;Dudanova & Klein 2013;Sutherland et al 2014;Akiyama & Kamiguchi 2015).…”

Section: Introductionmentioning

confidence: 99%

Exocytic and endocytic membrane trafficking in axon development

Tojima

Kamiguchi

2015

Dev Growth Differ

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In the complex neuronal circuits in the nervous systems, billions of neurons are precisely interconnected by long, thin processes called the axons. The growth cone, a highly motile structure at the tip of an extending axon, navigates by responding to a variety of extracellular molecular cues toward their distant target cells and make synaptic connections. Emerging evidence indicates that exocytic and endocytic membrane trafficking systems play multiple important roles in the regulation of such axonal morphogenetic processes. Exocytosis and endocytosis organize the subcellular distribution of membrane-associated molecules, such as receptors, cell adhesion molecules, and cytoskeletal regulators, to control intracellular signaling and driving machineries. Furthermore, the exocytosis of trophic factors and extracellular proteinases act on surrounding microenvironments to affect growth cone motility. In this Review Article, we summarize our current understanding of the regulation and function of exocytic and endocytic membrane trafficking in axon morphogenesis during development, and discuss potential mechanisms of how the membrane trafficking systems exert such morphological changes.

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“…In all cases, however, the mechanism of calcium signaling has not been fully understood. In animal systems, some calcium channels have been identified that could mediate calcium fluxes (Akiyama and Kamiguchi, 2015). However, little is known about the Ca 2+ transporters that mediate Ca 2+ fluxes in plant cells.…”

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confidence: 99%

Arabidopsis CNGC14 Mediates Calcium Influx Required for Tip Growth in Root Hairs

et al. 2017

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Root hairs create an enormous surface area to aid plants in nutrient and water acquisition, anchorage in the soil, and microbe interactions. Root hairs develop in two stages, including initiation and tip growth. Initiation occurs when a portion of genetically determined epidermal cells develop wall loosening and form a disc-shaped area of cell swelling. Tip growth happens after initiation when the root-hair ''bud'' elongates in a polarized fashion to eventually reach a tubular outgrowth with an apical dome (Grierson et al., 2014).

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Second messenger networks for accurate growth cone guidance

Cited by 16 publications

References 120 publications

Regulation of neuronal development and function by ROS

Regulation of neuronal development and function by ROS

Exocytic and endocytic membrane trafficking in axon development

Arabidopsis CNGC14 Mediates Calcium Influx Required for Tip Growth in Root Hairs

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