Second malignancies in melanoma patients in Thuringia

Wolff, Johannes; Wollina, Uwe

doi:10.1046/j.1468-3083.2000.00162.x

Cited by 16 publications

(16 citation statements)

References 37 publications

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“…Previous studies found incidences ranging from 2.0% to 8.0% [13, 15, 16, 52–54]. In accordance with previous studies, our data indicate that most subsequent CM occur within the first years after the initial diagnosis [13, 17, 53, 54].…”

Section: Discussionsupporting

confidence: 91%

Clinical Characteristics of Cutaneous Melanoma and Second Primary Malignancies in a Dutch Hospital-Based Cohort of Cutaneous Melanoma Patients

Velden

Rossum

Blokx

et al. 2009

Dermatology Research and Practice

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The increasing number of living cutaneous melanoma patients and the increased risk of developing a second primary tumour incited us to analyse the clinical characteristics of cutaneous melanoma and define the frequency, site, and type of second primary cancers in cutaneous melanoma patients. We collected data on patients who visited the Department of Dermatology at the Radboud University Nijmegen Medical Centre and were newly diagnosed with cutaneous melanoma or metastasis of melanoma with unknown primary localization between 2002 and 2006. A total of 194 cases were included; eleven patients developed a subsequent melanoma, 24 had at least one basal cell carcinoma, three had at least one squamous cell carcinoma, and 21 patients had a second non-cutaneous primary malignancy. In conclusion, 48 patients developed a subsequent malignancy. As nonmelanoma skin cancer is the most frequent second malignancy, our results subscribe to the necessity of follow-up by a dermatologist.

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Section: Discussionsupporting

confidence: 91%

Clinical Characteristics of Cutaneous Melanoma and Second Primary Malignancies in a Dutch Hospital-Based Cohort of Cutaneous Melanoma Patients

Velden

Rossum

Blokx

et al. 2009

Dermatology Research and Practice

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“…38 In the present study, the finding of 27,7% of the patients with a history of non-melanoma skin cancer is higher than that found in the literature. 39,40 One possible explanation would be the chronic exposure to the sun, which may also explain the elevated frequency of CM on the head and neck, even though this feature has not been evaluated by this study.…”

Section: Discussionmentioning

confidence: 87%

Epidemiological aspects of melanoma at a university hospital dermatology center over a period of 20 years

Brandão

Pereira

Bittencourt

2013

An. Bras. Dermatol.

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BACKGROUNDThe incidence of melanoma has been steadily rising in past decades. Although it accounts for only 3% of all skin cancers, it is responsible for 75% of deaths. OBJECTIVEto describe the epidemiological aspects of melanoma in a university hospital setting over a period of 20 years. METHODSA total of 166 patients were analyzed between January 1990 and January 2010 for clinical and histological variables and correlations between them. A 5% level of significance was adopted. RESULTSThe majority of patients were Caucasians (74%), females (61%), with a mean age at diagnosis of 55. The predominant histological type was lentigo maligna/lentigo maligna melanoma (35.7%) and the head and neck was the most affected site (30.7%). Among non-Caucasians, the acral region was the most affected. Most tumors were in situ (41.1%). Growth of the lesion was the most frequent complaint (58.1%) and bleeding was most frequently associated with melanomas with a depth > 4mm. There were seven deaths (4.2%), with a high risk among men, non-Caucasians and those under 20 years of age, with a Breslow's depth > 2mm, with lentiginous acral melanoma and with a history of growth and bleeding. CONCLUSIONSOur sample differs from most of the studies in the predominant location (head and neck), histological type (lentigo maligna/ lentigo maligna melanoma) and a major risk of death under the age of 20, which could be with a reflex of regional variation. Broader studies are necessary for validation of the results.

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“…2 Because case fatality has declined in recent decades, 3 more individuals with a CM diagnosis will survive to develop a second primary malignancy (SPM). Patients with melanoma have been reported previously to have increased relative risk for particular SPMsenamely, second primary melanomas (standardized incidence ratio [SIR] range, 4.7-33.8), 4-7 nonmelanoma skin cancer (SIR range, 3.10-4.40), 4,8,9 lymphoma (SIR range, 1.42-16.1), 4,10,11 and cancers of the breast (SIR range, 1.10-6.6), 4,[12][13][14] thyroid (SIR range, 2.1-3.6), 4,15 pancreas (SIR range 0.6-1.76), 4,16-18 bladder (SIR range, 0.9-3.30), 4,19 prostate (SIR range, 1.50-2.10), 4,8,13,19 central nervous system (SIR range, 1.1-1.57, 4,20 and gastrointestinal tract (SIR range, 1.1-1.33). 4,21 However, reported SIRs have not been consistent across studies.…”

mentioning

confidence: 99%

Risk of second primary malignancies following cutaneous melanoma diagnosis: A population-based study

Spanogle¹,

Clarke²,

Aroner³

et al. 2010

Journal of the American Academy of Dermatology

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Second malignancies in melanoma patients in Thuringia

Cited by 16 publications

References 37 publications

Clinical Characteristics of Cutaneous Melanoma and Second Primary Malignancies in a Dutch Hospital-Based Cohort of Cutaneous Melanoma Patients

Clinical Characteristics of Cutaneous Melanoma and Second Primary Malignancies in a Dutch Hospital-Based Cohort of Cutaneous Melanoma Patients

Epidemiological aspects of melanoma at a university hospital dermatology center over a period of 20 years

Risk of second primary malignancies following cutaneous melanoma diagnosis: A population-based study

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