Second malignancies in children with neuroblastoma after combined treatment with ¹³¹I‐metaiodobenzylguanidine

Abstract

A novel approach is presented for the solution of production planning problems for multiproduct processes. A mixed‐integer programming (MIP) scheduling model is analyzed off‐line to obtain a convex approximation of feasible production levels and a convex underestimation of total production cost as a function of production levels. The two approximating functions are expressed via linear inequalities that involve only planning variables yet provide all the relevant scheduling information necessary to solve the planning problem with high quality. A rolling horizon algorithm is also presented for generation (if necessary) of detailed schedules. © 2007 American Institute of Chemical Engineers AIChE J, 2007

Norepinephrine Transporter as a Target for Imaging and Therapy

“…The incidence of secondary malignancy is similar to that observed in children treated with chemotherapy with a cumulative incidence of 7.6% and 14.3% at 5 and 10 y after therapy, respectively (103). Secondary malignancies including acute nonlymphoblastic leukemia, chronic myelomonocytic leukemia, angiomatoid malignant fibrous histiocytoma, malignant schwannoma, and rhabdomyosarcoma have been reported to occur at a median of 3 y (1-15 y) (104).…”

Second malignancies after childhood noncentral nervous system solid cancer: Results from 13 cancer registries

“…3,8,25,26 Treatment may involve alkylating agents, topoisomerase II inhibitors, (131)I-metaiodobenzylguanidine [(131)I-MIBG], platinums and/or radiation, that have been associated with an increased risk of secondary leukemias, bone marrow disorders, and solid tumors (breast cancer and thyroid cancer), and more recently, bone marrow transplantation, which has been associated to an increased risk of secondary solid tumors. 26 Second malignant neoplasms of the kidney and digestive organs have also been observed.…”

Intensified External-Beam Radiation Therapy Improves the Outcome of Stage 4 Neuroblastoma in Children > 1 Year with Residual Local Disease

“…External-beam radiation therapy (EBRT) proved effective in small series of localized neuroblastoma [7] and infants' neuroblastoma [24] but data in high-risk neuroblastoma are still limited [5,13,19]. Radiation can cause long-term effects like scoliosis, soft-tissue hypoplasia, hypothyroidism, and secondary malignant disease [1,11,14,21,23,24,26,30] and should, therefore, be applied only when clearly indicated.…”