“…In clinical practice, some patients with confirmed CD exhibit equivocal results to dynamic tests, and it is not uncommon that some EAS act like a pituitary corticotropinoma. In addition, imaging is not always helpful, because gadolinium‐enhanced MRI is able to detect pituitary tumours in roughly 40%‐50% of patients with CD, and furthermore incidental pituitary lesions have been reported in the general population, including a minority of patients with EAS . Bilateral inferior petrous sinus sampling (BIPSS) may provide adjuvant data; however, this invasive procedure requires specific expertise to perform catheterization (to minimize side effects) and to analyse results (to avoid false positives or negatives) .…”