Second line prevention from esophageal cancer inhibitory therapy to block precancerous lesions

Lin, Pei-Zhong; Zhang, Jinsheng; Cao, Shi-Guo; Han, Rui; Xu, Shan; Xu, Zhen-Peng; Gao, Run-Quan

doi:10.1007/bf02997638

Cited by 6 publications

(4 citation statements)

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“…More and better designed trials and possibly a systematic review of literature on TCP available in the Western world are needed. Wang [98] Chen [94] without name [93] Shen [92] Shi [67] Jiang [62] Wu [105] Hu [106] Liao [107] Fang [108] Li [68] Drabaek [64] Drabaek [63] Li [78] Hsieh [77] Worm [49] Ramgolam [38] Fung [48] Armstrong [47] Koo [46] Sheehan [44] Sheehan [43] Latchmann [42] Sheehan [40] Sheehan [41] Atherton [39] Batey [25] Akbar [24] Chen [14] Hirayama [13] Caceres [80] Scaglione [72] (continued) Chen [86] Liang [83] Hale [82] Chen [20] Tatsuta [19] Hou [17] Lin [6] Lin [12] Charuwichitratana [71] Sangkitporn [69] Davis [33] Hirata [32] Ding [30] Wang [28] Ramgolam …”

Section: Resultsmentioning

confidence: 99%

Availability of Research Results on Traditional Chinese Pharmacotherapy

Pach¹,

Willich²,

Becker-Witt³

2002

Complement Med Res

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Introduction: The use of Traditional Chinese Medicine (TCM) has been increasing in the Western world over the last few years. Although Traditional Chinese Pharmacotherapy (TCP) plays a central role in TCM treatment in China, acupuncture is a more common form of treatment in the Western world than TCP. Objective: The aim of our study was to evaluate the quantity and availability of clinical trials on TCP using Medline. Methods: Medline searches were performed in PubMed (1966–June 2001) using the MeSH (Medical Subjects Heading) term ‘drugs, Chinese herbal.’ In a second step we restricted the search to meta-analyses, reviews, randomized controlled trials and clinical trials. Additionally we used the PubMed-Research- Methodology-Filter. Abstracts and information concerning the publication type were used to assess the available information. Results: Using the MeSH term ‘drugs, Chinese herbal’, 6,504 publications (50% in Chinese) published in 662 journals were identified. The specific search using the PubMed-Research-Methodology-Filter adjusted to ‘therapy’ and ‘specificity’ identified 118 studies (11 reviews, 55 randomized controlled trials, 26 controlled trials, 7 longitudinal studies, 12 experiments, and 7 others), 65 of which were written in English. Most studies used western diagnoses for treatment. The most common investigated diagnosis was atopic dermatitis (7 trials) followed by angina pectoris (6 trials). Conclusion: Only limited information about TCP research is accessible for physicians using PubMed. Moreover, half of the studies are published in Chinese. The PubMed-Research- Methodology-Filter proved to be an effective tool in restricting the search to relevant publications.

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Section: Resultsmentioning

confidence: 99%

Availability of Research Results on Traditional Chinese Pharmacotherapy

Pach¹,

Willich²,

Becker-Witt³

2002

Complement Med Res

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“…Evidence for a beneficial effect on premalignancy was observed in four of these studies: the combination of retinol+riboflavin+zinc reduced micronuclei (84); multivitamins improved cytology (90); selenomethionine improved histology (92); and strawberries improved histology and reduced proliferation and expression of several cancer-related proteins (94). A benefit for cancer was observed for antitumor B (85) and riboflavin (85), and was suggested among persons whose communities received riboflavin-fortified salt (93). …”

Section: Prospects and Implications For Preventionmentioning

confidence: 99%

Squamous Dysplasia—The Precursor Lesion for Esophageal Squamous Cell Carcinoma

Taylor

Abnet

Dawsey

2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

133

100

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Esophageal squamous cell carcinoma (ESCC) accounts for 80% of all esophageal cancers worldwide, and esophageal squamous dysplasia (ESD) is the only histopathology that predicts the development of ESCC. The prevalence of ESD parallels rates of invasive ESCC, and is typically found in 25% or more of adults above the age of 35 years in populations in north central China, where risk for ESCC is among the highest in the world. Results of chemoprevention and early detection studies to prevent progression of ESD suggest that these approaches, coupled with emerging endoscopic therapies, offer promise for the prevention of esophageal cancer mortality in high-risk populations. Future research on ESD and ESCC should focus on finding additional modifiable risk factors and on identifying biomarkers to incorporate into early detection strategies.

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“…Recipe Antitumor B is a complex recipe of traditional Chinese medicine consisting of six medicinal herbs: Sophora subprostrata Chua et Chen, Patrinia villosa Thumb, Dictamnus dasycapus, Dyscoria bulbifera L., Prumilla vugalis L, and Polygonum historia L. Lin et al [18] have reported that Recipe Antitumor B dramatically inhibited esophageal carcinogenesis induced by nitrosamine in rats. Wei and Nishimura [19] and Lin et al [20] have reported that Recipe Antitumor B has a significant inhibitory effect on DMBA-induced buccal pouch carcinoma in hamsters.…”

Section: Recipe Antitumor Bmentioning

confidence: 99%

Research and development of cancer chemopreventive agents in China

Han¹

1997

J. Cell. Biochem.

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Since the late 1970s, a comprehensive search for cancer chemopreventive agents has been established in our Institute. A series of new retinoids have been synthesized and screened on the basis of established methodologies of experimental chemoprevention in vitro as well as in vivo. Pharmacological studies demonstrated that N-4-(carboxyphenyl)retinamide (RII) induces cell differentiation of HL-60 cells and inhibits dimethylnitrosamine-induced carcinogenesis of the forestomach in mice, 7,12-dimethylbenz[a]anthracene (DMBA)-induced papilloma in mouse skin, and DMBA-induced carcinogenesis of the buccal pouch in Syrian golden hamsters. It significantly promoted lymphoblastic transformation and activated macrophages. In further studies, RII significantly inhibited ornithine decarboxylase activity. After 6 months of chronic toxicological studies in rats and dogs, RII was recommended for clinical trial. Phase II studies found that RII is effective in treating oral and vulvar leukoplakia. It is also effective in treating myelodysplastic syndrome and dysplasia of uterine cervix. The chalcone retinoidal compounds were discovered when the search for new retinoids with less toxicity and higher potency led to third-generation retinoids, which were synthesized and screened. Structure-activity relationship studies found that 3,5-di-tert-butyl-4-methoxy-4-carboxyl chalcone (R9158) is the most active inhibitor of a variety of cancer cells. It has no effect on the Colony Forming Unit-Granulocyte/ Macrophage (CFU-GM) of bone marrow in mice. In in vivo studies, R9158 showed a remarkable inhibition of chondrosarcoma in rats. It had no cross-resistance to vincristine, but was cross-resistant to all-trans retinoic acid. Red ginseng, a processed Panax ginseng, is considered a typical tonic in traditional Chinese medicine. Our studies demonstrated that red ginseng extract inhibited DMBA-induced skin papilloma significantly. Experiments showed that glycyrrhetinic acid inhibited croton oil-induced ear edema in mice. It also inhibited epidermal ornithine decarboxylase as well as the rapid DNA damage induced by the carcinogen benzo[a]pyrene (B[a]P). Our pharmacological studies demonstrated that Chinese gallotannin inhibited the malignant transformation of B[a]P-induced V79 cells in vitro and B[a]P-induced pulmonary adenoma in A/J mice in vivo significantly.

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Second line prevention from esophageal cancer inhibitory therapy to block precancerous lesions

Cited by 6 publications

References 0 publications

Availability of Research Results on Traditional Chinese Pharmacotherapy

Availability of Research Results on Traditional Chinese Pharmacotherapy

Squamous Dysplasia—The Precursor Lesion for Esophageal Squamous Cell Carcinoma

Research and development of cancer chemopreventive agents in China

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