Second eye of patients with unilateral neovascular age-related macular degeneration: Caucasians vs Chinese

Sivaprasad, Sobha; Membrey, W L; Sivagnanavel, Vasuki; Gonzalez, J.G.; Liu, D T L; Chan, Wai‐Man; Lam, Dennis S.C.; Jackson, Heather; Chong, Victor

doi:10.1038/sj.eye.6702056

Cited by 11 publications

(3 citation statements)

References 22 publications

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“…The exudative form is the leading cause of irreversible vision loss in subjects over 65 years of age living in economically developed countries and accounts for >80% of cases of legal blindness associated with the disease [5–7]. Risk estimation is crucial in order to provide adequate patient monitoring.…”

Section: Introductionmentioning

confidence: 99%

Ocular Risk Factors for Exudative AMD: A Novel Semiautomated Grading System

et al. 2013

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Purpose. To evaluate the contribution of the ocular risk factors in the conversion of the fellow eye of patients with unilateral exudative AMD, using a novel semiautomated grading system. Materials and Methods. Single-center, retrospective study including 89 consecutive patients with unilateral exudative AMD and ≥3 years of followup. Baseline color fundus photographs were graded using an innovative grading software, RetmarkerAMD (Critical Health SA). Results. The follow-up period was 60.9 ± 31.3 months. The occurrence of CNV was confirmed in 42 eyes (47.2%). The cumulative incidence of CNV was 23.6% at 2 years, 33.7% at 3 years, 39.3% at 5 years, and 47.2% at 10 years, with a mean annual incidence of 12.0% (95% CI = 0.088–0.162). The absolute number of drusen in the central 1000 and 3000 μm (P < 0.05) and the absolute number of drusen ≥125 µm in the central 3000 and 6000 µm (P < 0.05) proved to be significant risk factors for CNV. Conclusion. The use of quantitative variables in the determination of the OR of developing CNV allowed the establishment of significant risk factors for neovascularization. The long follow-up period and the innovative methodology reinforce the value of our results. This trial is registered with ClinicalTrials.gov NCT00801541.

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Section: Introductionmentioning

confidence: 99%

Ocular Risk Factors for Exudative AMD: A Novel Semiautomated Grading System

et al. 2013

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“…Abugreen et al [21] found that the fellow eyes of occult CNV have significantly more severe AMD features compared to eyes with classic CNV. Similarly, Sivaprasad et al [23] showed that this kind of association between the CNV type in the affected eye and the severity of the disease in the fellow eye can only be applied on Caucasians, compared to Chinese patients who did not show a similar disease pattern.…”

Section: Discussionmentioning

confidence: 99%

“…The drusen load findings of our study support findings reported previously in the literature. It has been reported that the clinical features in the fellow eye correlate with the type of CNV in the affected eye in AMD patients with unilateral CNV using colour fundus photography [21,23]. Abugreen et al [21] found that the fellow eyes of occult CNV have significantly more severe AMD features compared to eyes with classic CNV.…”

Section: Discussionmentioning

confidence: 99%

Association of Longitudinal Changes in Drusen Characteristics and Retinal Layer Volumes with Subsequent Subtype of Choroidal Neovascularisation

2019

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Aim: To investigate the longitudinal correlation between drusen characteristics and retinal layer volumes pre conversion and subsequent type of choroidal neovascularisation (CNV). Methods: This was a single-centre retrospective study. The study participants were patients with wet age-related macular degeneration (AMD) in one eye who developed wet AMD in the contralateral eye, with at least 2 years of follow-up prior to conversion. The Moorfields Eye Hospital database was searched for eligible patients and their data were recorded. Eyes were classified as occult or classic based on fundus fluorescein angiography. Optical coherence tomography (OCT) images were analysed for drusen characteristics and retinal layer volumes were analysed over time using automated software (Topcon 3D OCT-2000 and Orion, Voxeleron LLC, respectively). All values were obtained at baseline as well as year 1 and year 2 before conversion to wet AMD. Results: Fifty-one eyes with bilateral CNV showed high correlation of type of CNV between eyes (kappa statistic 0.89). A total of 49 wet AMD eyes (29 occult, 20 classic) were analysed for drusen parameters. Two patients with retinal angiomatous proliferation were excluded. Drusen count, area, and volume did not differ by CNV type, but the rates of change of drusen area (p = 0.046) and drusen volume (0.022) were higher in the occult group in the year preceding CNV development. Of the 49 eyes, 17 (10 occult, 7 classic) with available good quality OCT were analysed for retinal layer volumes. There was a progressive reduction in outer nuclear layer (ONL) volume (p = 0.002) and an expansion in outer plexiform layer volume (p = 0.015) in eyes that developed occult CNV. Conclusion: Our study shows that rate of increase in drusen load and reduction in ONL are significant features seen in eyes developing occult CNV, highlighting new imaging markers that need to be replicated in larger studies. These markers provide insight into the pathogenesis of CNV and may serve as prognostic indicators, as classic CNV carries a poorer prognosis compared to occult CNV.

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