Second Dissociation Constant of Bis-[(2-hydroxyethyl)amino]acetic Acid (BICINE) and pH of Its Buffer Solutions from 5 to 55 °C

Dissociation Constant of N-(2-Acetamido)-Iminodiacetic Acid Monosodium (ADA) from (278.15 to 328.15) K

“…The hydrolysis corrections of m 1 /m 2 are negligible because of the pH of buffer solutions of NaADA and Na 2 ADA is very close to neutrality. In the present study this observation is consistent with other investigations of structurally related buffer compounds [3] [4]. The ionic strength of the solution for cell (B) is indicated by:…”

“…The parent compound (GLYCINE) [1] has a pK 2 of 9.780 and whereas for (TRICINE) [ increase of the acidic strength for the protonated nitrogen group. It is worthwhile to mention that as the number of -CH 2 OH group becomes greater, the enhancement of the acidity decreases as in the case of (GLYCINE) [1], (BICINE) [3] and (TRICINE) [2]. This trend is consistent for ADA (present study in Table 4).…”

“…The results along with the standard deviation of regression estimated by the method of Please [15], are entered in Table 3. The thermodynamic quantities at 298.15 K for the dissociation of (GLYCINE) [1] and some substituted GLYCINES such as, (BI-CINE) [3], (TRICINE) [2], (N,N-dimethyglycine) [16], and (ADA) [6 and this work] are compiled in Table 4.…”

“…Included were 2-aminoethanoic acid (GLYCINE) [1], N-tris(hydroxymethyl)methylglycine (TRICINE) [2] and bis-[(2-hydroxyethyl)amino] acetic acid (BICINE) [3]. We have also studied thermodynamic quantities for the dissociation of a series of some substituted TAURINE such as N-tris[hydroxymethy]-4-aminoethanesulfonic acid (TABS) [4] and (3-[N-morpholino])]-2-hydroxypropanesulfonic acid (MOPSO) [5] from 278.15 to 328.15 K. In order to provide useful pH standard buffer for the control of acidity in the pH range 6.5 to 8.5, which is important for studies of clinical fluids and physiological media of ionic strength I = 0.16 mol•kg −1 , we have undertaken to study acid-base behavior, and to determine values for the second dissociation constant pK 2 and thermodynamic functions of N-(2-acetamido)iminodiacetic acid (ADA) in the temperature range 278.15 K to 328.15 K in an earlier publication [6].…”

Standards for pH Measurements of Bis-[(2-Hydroxyethyl)amino]acetic Acid (BICINE) from (278.15 to 328.15) K

“…Good et al [1,2] have recommended a set of zwitterionic amino acid buffers for the investigation of physiological solutions across a broad pH range.The second dissociation constant (pK 2 ) of the zwitterionic buffer BICINE has recently been published [3]. Standard pH values of six buffer solutions of BICINE and NaBICINE without NaCl in the ionic strength range I = 0.02 to 0.08 mol·kg -1 and four buffer solutions in isotonic saline media of I = 0.16 mol·kg -1 with NaCl from (278.15 to 328.15) K have been reported earlier from this laboratory [3].…”