Second dissociation constant of 3-(N-morpholino)-2-hydroxypropanesulfonic acid and pH of its buffer solutions

Wu, Yung‐Chi; Berezansky, P. A.; Feng, Donghai; Koch, William F.

doi:10.1021/ac00056a023

Cited by 29 publications

(52 citation statements)

References 7 publications

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“…The values of the liquid junction potential, E j , for the phosphate buffer and the buffer solutions were obtained using the flowing junction method [8]. The δE j values of the standard buffer solution for cell (B) were calculated using the following equation:…”

Section: Methods and Resultsmentioning

confidence: 99%

“…The goal of the current investigation is to provide reliable and accurate pH values for the N-substituted amino acid buffer BICINE, the structure of which is given in Fig. (1 Wu and associates [7,8] have published pH and pK 2 values for N-(2-hydroxyethyl)piperazine-N′-2-ethanesulfonic acid, HEPES; and MOPSO. Roy et al [9] reported pK 2 and pH values of N-substituted aminopropane sulfonic acid DIPSO buffer.…”

Section: Introductionmentioning

confidence: 99%

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Standards for pH Measurements of Bis-[(2-Hydroxyethyl)amino]acetic Acid (BICINE) from (278.15 to 328.15) K

Roy¹,

Roy²,

Bodendorfer³

et al. 2013

TOELECJ

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Abstract:The second dissociation constant, pK 2 , and related thermodynamic data for BICINE have been previously determined and reported from temperatures (278.15 to 328.15) K. For the present study, three buffer solutions without NaCl, and five with NaCl yielding an ionic strength (I = 0.16 mol·kg -1 ) similar to that of blood plasma were prepared. These buffer solutions have been evaluated in the temperature range of (278.15 to 328.15) K using the extended form of the Debye-Hückel equation. The Bates-Guggenheim convention is only valid when I< 0.1 mol·kg -1 . Values of the residual liquid junction potential (δE j ) between the BICINE solutions and the saturated KCl calomel electrode have been estimated at (298.15 and 310.15) K. Two BICINE buffer solutions are recommended as primary standard reference solutions for pH measurements of biological fluids.

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Section: Methods and Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Standards for pH Measurements of Bis-[(2-Hydroxyethyl)amino]acetic Acid (BICINE) from (278.15 to 328.15) K

Roy¹,

Roy²,

Bodendorfer³

et al. 2013

TOELECJ

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show abstract

“…lo ecessary in the assignment of pH values for standards of reference buffer solutions [8,10,[14][15][16][17][18]. The Eq.…”

Section: Methods and Resultsmentioning

confidence: 99%

“…The values of pK 2 and pH for the buffer HEPES have been published by Feng and coworkers [8]. The thermodynamic quantities (pK 2 and pH) of physiological buffers MOPS and MOPSO have been published by Roy and coworkers [9], and Wu and associates [10], respectively. These buffer solutions lie in the physiological pH range 6-8.…”

Section: Fig (1) N-(2-hydroxyethyl)piperazine-n'(4-butanesulfonic Amentioning

confidence: 99%

Buffer Standards for the Physiological pH of N-(2-Hydroxyethyl) piperazine-N'-4-butanesulfonic Acid (HEPBS) from 5 to 55 °C

Roy¹,

Roy

Allen³

et al. 2012

TOELECJ

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Abstract:The pH values of six buffer solutions of equal compositions on the molal scale and eight buffer solutions having ionic strengths (I = 0.16 mol·kg -1 ) similar to the concentration of blood plasma have been evaluated at 12 temperatures from 5 to 55 °C using the Bates-Guggenheim convention and extended Debye-Hückel equation. The values of E j for the buffer solution of HEPBS have been obtained from the flowing junction cell measurement. These values of E j have been used to ascertain the operational pH values at 25 and 37 °C for HEPBS buffer solution. The pH values at 25 and 37 °C are 7.415 and 7.395, respectively, for physiological phosphate buffer solutions. The zwitterionic buffer HEPBS was shown to be useful as a secondary pH standard in the region close to that of blood serum.

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“…This phosphate buffer contains 0.008695 mol·kg −1 KH 2 PO 4 and 0.03043 mol·kg −1 Na 2 HPO 4 . Because of problems associated with the current phosphate buffer [7][8][9], we have been prompted to investigate some zwitterionic buffers including TES for use in physiological pH range 6.5 -7.5.…”

Section: Introductionmentioning

confidence: 99%

Buffer Standards for the Biochemical pH of the Zwitterionic Buffer <i>N</i>-Tris-(Hydroxymethyl) Methyl-2-Aminoethanesulfonic Acid (TES) from 5℃ to 55℃

Roy¹,

Roy²,

Bodendorfer³

et al. 2012

OJPC

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The authors have undertaken the determination of pH values for one buffer solution of TES without NaCl and nine buffer solutions with NaCl yielding an ionic strength I = 0.16 mol·kg -1 similar to that of blood. These buffer solutions have been evaluated in the temperature range of 5˚C to 55˚C using an extended version of the Debye-Hückel equation.The pH values are reported using 1) the Debye-Hückel extension of the Bates-Guggenheim convention in the temperature range 5˚C to 55˚C and 2) with and without liquid junction correction at 25˚C and 37˚C. These TES buffer solutions are recommended as secondary standard references for pH measurements in the range of pH 7.2 to 7.5 for physiological application with an ionic strength of I = 0.16 mol·kg -1 .

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Second dissociation constant of 3-(N-morpholino)-2-hydroxypropanesulfonic acid and pH of its buffer solutions

Cited by 29 publications

References 7 publications

Standards for pH Measurements of Bis-[(2-Hydroxyethyl)amino]acetic Acid (BICINE) from (278.15 to 328.15) K

Standards for pH Measurements of Bis-[(2-Hydroxyethyl)amino]acetic Acid (BICINE) from (278.15 to 328.15) K

Buffer Standards for the Physiological pH of N-(2-Hydroxyethyl) piperazine-N'-4-butanesulfonic Acid (HEPBS) from 5 to 55 °C

Buffer Standards for the Biochemical pH of the Zwitterionic Buffer <i>N</i>-Tris-(Hydroxymethyl) Methyl-2-Aminoethanesulfonic Acid (TES) from 5℃ to 55℃

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Second dissociation constant of 3-(N-morpholino)-2-hydroxypropanesulfonic acid and pH of its buffer solutions

Cited by 29 publications

References 7 publications

Standards for pH Measurements of Bis-[(2-Hydroxyethyl)amino]acetic Acid (BICINE) from (278.15 to 328.15) K

Standards for pH Measurements of Bis-[(2-Hydroxyethyl)amino]acetic Acid (BICINE) from (278.15 to 328.15) K

Buffer Standards for the Physiological pH of N-(2-Hydroxyethyl) piperazine-N'-4-butanesulfonic Acid (HEPBS) from 5 to 55 °C

Buffer Standards for the Biochemical pH of the Zwitterionic Buffer &lt;i&gt;N&lt;/i&gt;-Tris-(Hydroxymethyl) Methyl-2-Aminoethanesulfonic Acid (TES) from 5℃ to 55℃

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Buffer Standards for the Biochemical pH of the Zwitterionic Buffer <i>N</i>-Tris-(Hydroxymethyl) Methyl-2-Aminoethanesulfonic Acid (TES) from 5℃ to 55℃