Second dissociation constant and pH of N-(2-hydroxyethyl)piperazine-N'-2-ethanesulfonic acid from 0 to 50.degree. C

Feng, Donghai; Koch, William F.; Wu, Yung‐Chi

doi:10.1021/ac00188a019

Cited by 56 publications

(107 citation statements)

References 15 publications

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“…An extended Debye-Hückel equation [7,9] has been selected to be the more logical approach to calculate when I is greater than 0.1 mol·kg -1 for all of the buffer solutions containing Cl¯.…”

Section: Methods and Resultsmentioning

confidence: 99%

“…The goal of the current investigation is to provide reliable and accurate pH values for the N-substituted amino acid buffer BICINE, the structure of which is given in Fig. (1 Wu and associates [7,8] have published pH and pK 2 values for N-(2-hydroxyethyl)piperazine-N′-2-ethanesulfonic acid, HEPES; and MOPSO. Roy et al [9] reported pK 2 and pH values of N-substituted aminopropane sulfonic acid DIPSO buffer.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Standards for pH Measurements of Bis-[(2-Hydroxyethyl)amino]acetic Acid (BICINE) from (278.15 to 328.15) K

Roy¹,

Roy²,

Bodendorfer³

et al. 2013

TOELECJ

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Abstract:The second dissociation constant, pK 2 , and related thermodynamic data for BICINE have been previously determined and reported from temperatures (278.15 to 328.15) K. For the present study, three buffer solutions without NaCl, and five with NaCl yielding an ionic strength (I = 0.16 mol·kg -1 ) similar to that of blood plasma were prepared. These buffer solutions have been evaluated in the temperature range of (278.15 to 328.15) K using the extended form of the Debye-Hückel equation. The Bates-Guggenheim convention is only valid when I< 0.1 mol·kg -1 . Values of the residual liquid junction potential (δE j ) between the BICINE solutions and the saturated KCl calomel electrode have been estimated at (298.15 and 310.15) K. Two BICINE buffer solutions are recommended as primary standard reference solutions for pH measurements of biological fluids.

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Section: Methods and Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Standards for pH Measurements of Bis-[(2-Hydroxyethyl)amino]acetic Acid (BICINE) from (278.15 to 328.15) K

Roy¹,

Roy²,

Bodendorfer³

et al. 2013

TOELECJ

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“…The pH of the distal colon of fed healthy adults is reported to be approximately 8.1 (35). Table 3 provides pKa' data for buffers relative to this target pH range (3,9,16,17,25,34,(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47). The buffers listed first are those included in the formulations for the simulated biological fluids provided in Marques et al (3) and Klein (9).…”

Section: Relationship Between the Target Dissolution Media Ph And Bufmentioning

confidence: 99%

Physicochemical Properties of Buffers Used in Simulated Biological Fluids with Potential Application for In Vitro Dissolution Testing: A Mini-review

Mauger¹

2017

Dissolution Technol.

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Although aqueous buffers alone cannot be expected to fulfill all the requirements of biorelevant media, buffers will likely continue to play a central role in controlling the pH of complex formulations simulating biological fluids (3,9). The use of biorelevant dissolution media to forecast in vivo drug performance has been reviewed (9). This minireview focuses on the physicochemical factors related to buffers used in these media and not the biorelevant dissolution media, per se. This mini-review is based on a survey of the literature associated with buffers in general ABSTRACTThis literature review focuses on the physicochemical properties of buffers used in biorelevant media for in vitro dissolution testing. Because biorelevant dissolution systems have been previously reviewed, this review is primarily related to the buffers used in biorelevant media and not the media, per se. It is based on a survey of the literature in areas including analytical chemistry; biochemistry; clinical, solution, and physical chemistry; dissolution science and technology; pharmaceutical sciences; simulated biological fluids; and buffer-related articles from the National Institute of Standards and Technology with the intent of identifying challenges in formulating buffered biorelevant dissolution media and also identifying general attributes that are useful in selecting a buffer for a particular dissolution application. Other topics include: (1) key physicochemical properties of buffers that affect experimental conditions and dissolution results; (2) buffer compatibility with a diverse array of ingredients found in biorelevant media; and (3) the potential to supplement the library of traditional buffers used for in vitro dissolution testing with zwitterionic buffers that were designed for biological application.

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“…The following empirical equation is used for the calculation of the adjustable parameter "C" [8,10].…”

Section: R N Roy Et Al 44mentioning

confidence: 99%

“…This phosphate buffer contains 0.008695 mol·kg −1 KH 2 PO 4 and 0.03043 mol·kg −1 Na 2 HPO 4 . Because of problems associated with the current phosphate buffer [7][8][9], we have been prompted to investigate some zwitterionic buffers including TES for use in physiological pH range 6.5 -7.5.…”

Section: Introductionmentioning

confidence: 99%

Buffer Standards for the Biochemical pH of the Zwitterionic Buffer <i>N</i>-Tris-(Hydroxymethyl) Methyl-2-Aminoethanesulfonic Acid (TES) from 5℃ to 55℃

Roy¹,

Roy²,

Bodendorfer³

et al. 2012

OJPC

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The authors have undertaken the determination of pH values for one buffer solution of TES without NaCl and nine buffer solutions with NaCl yielding an ionic strength I = 0.16 mol·kg -1 similar to that of blood. These buffer solutions have been evaluated in the temperature range of 5˚C to 55˚C using an extended version of the Debye-Hückel equation.The pH values are reported using 1) the Debye-Hückel extension of the Bates-Guggenheim convention in the temperature range 5˚C to 55˚C and 2) with and without liquid junction correction at 25˚C and 37˚C. These TES buffer solutions are recommended as secondary standard references for pH measurements in the range of pH 7.2 to 7.5 for physiological application with an ionic strength of I = 0.16 mol·kg -1 .

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Second dissociation constant and pH of N-(2-hydroxyethyl)piperazine-N'-2-ethanesulfonic acid from 0 to 50.degree. C

Cited by 56 publications

References 15 publications

Standards for pH Measurements of Bis-[(2-Hydroxyethyl)amino]acetic Acid (BICINE) from (278.15 to 328.15) K

Standards for pH Measurements of Bis-[(2-Hydroxyethyl)amino]acetic Acid (BICINE) from (278.15 to 328.15) K

Physicochemical Properties of Buffers Used in Simulated Biological Fluids with Potential Application for In Vitro Dissolution Testing: A Mini-review

Buffer Standards for the Biochemical pH of the Zwitterionic Buffer <i>N</i>-Tris-(Hydroxymethyl) Methyl-2-Aminoethanesulfonic Acid (TES) from 5℃ to 55℃

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Second dissociation constant and pH of N-(2-hydroxyethyl)piperazine-N'-2-ethanesulfonic acid from 0 to 50.degree. C

Cited by 56 publications

References 15 publications

Standards for pH Measurements of Bis-[(2-Hydroxyethyl)amino]acetic Acid (BICINE) from (278.15 to 328.15) K

Standards for pH Measurements of Bis-[(2-Hydroxyethyl)amino]acetic Acid (BICINE) from (278.15 to 328.15) K

Physicochemical Properties of Buffers Used in Simulated Biological Fluids with Potential Application for In Vitro Dissolution Testing: A Mini-review

Buffer Standards for the Biochemical pH of the Zwitterionic Buffer &lt;i&gt;N&lt;/i&gt;-Tris-(Hydroxymethyl) Methyl-2-Aminoethanesulfonic Acid (TES) from 5℃ to 55℃

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Buffer Standards for the Biochemical pH of the Zwitterionic Buffer <i>N</i>-Tris-(Hydroxymethyl) Methyl-2-Aminoethanesulfonic Acid (TES) from 5℃ to 55℃