Second derivative synchronous fluorescence determination of avanafil in the presence of its acid-induced degradation product aided by powerful Lean Six Sigma tools augmented with D-optimal design

Attia, Khalid A.M.; Mohamad, Ahmad A.; Emara, Mohamed S.; Abdel-Raoof, Ahmed M.; Hasan, M. A.; Madkour, Ahmed W.; El-Desouky, Ebrahim A.

doi:10.1039/d0ra08216c

Cited by 13 publications

(1 citation statement)

References 34 publications

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“…Because the amplitude of the derivative signal has an inverse relationship to the bandwidth of the original spectrum, combining SFS with derivatives allows for sensitivity differentiation of the standard emission spectrum [34]. Derivative synchronous fluorometry (DSF) has been used in recent years to analyze various combinations in coadministered and biological fluid samples [35][36][37][38][39][40].…”

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confidence: 99%

A novel sustainable second‐derivative synchronous spectrofluorimetric method for the simultaneous determination of olmesartan medoxomil and rosuvastatin calcium in bulk and formulations: Integrated greenness and whiteness evaluation

Batakoushy,

Nasr,

Soliman

et al. 2023

Luminescence

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The present research has established a quick and highly sensitive second‐derivative synchronous fluorometric technique for the simultaneous quantification of a binary mixture of olmesartan medoxomil and rosuvastatin calcium. Simultaneously, the suggested approach was used to detect the synchronous fluorescence intensity of the cited drugs at Δ λ = 80 nm in ethanol to determine the concentrations of olmesartan medoxomil and rosuvastatin calcium at 265 and 240 nm, respectively. Various experimental conditions were tested, and each variable was analyzed and optimized. The calibration graphs were shown to be linear within ranges of 0.1–2.0 and 0.5–6.0 μg ml−1 for each drug concentration, respectively. The newly developed Green Solvents Selecting Tool (GSST) was utilized to assess the solvent's sustainability. Furthermore, the proposed method was found to be environmentally friendly after being evaluated with three different tools [the Green Analytical Procedure Index (GAPI), the Analytical Greenness Metric (AGREE), and the Analytical Eco‐Scale with Eco‐score equal to 95]. The whiteness qualities were also studied using the Red–Green–Blue (RGB12) model, which was recently designed and showed a high score equal to 92.9. The proposed method’s good findings, as well as its ongoing sustainability, simplicity, and economy, stimulate its application in QC laboratories.

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