Second bone marrow transplantation into regenerating hematopoiesis enhances reconstitution of immune system
Kateřina Faltusová,
Martin Báječný,
Tomáš Heizer
et al.
Abstract:In bone marrow transplantation (BMT), hematopoiesis-reconstituting cells are introduced following myeloablative treatment, which eradicates existing hematopoietic cells and disrupts stroma within the hematopoietic tissue. Both hematopoietic cells and stroma then undergo regeneration. Our study compares the outcomes of a second BMT administered to mice shortly after myeloablative treatment and the first BMT, with those of a second BMT administered to mice experiencing robust hematopoietic regeneration after the… Show more
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