Secoisolariciresinol diglucoside protects against cadmium-induced oxidative stress-mediated renal toxicity in rats

AlRamadneh, Tareq Nayef; Gurumallu, Sunil Chikkalakshmipura; Bhaskar, Ashwini; Hashimi, Saeed Mujahid; Javaraiah, Rajesh

doi:10.1016/j.jtemb.2020.126552

Cited by 18 publications

(16 citation statements)

References 36 publications

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“…Similar to polyphenols, the antioxidant and anti-inflammatory properties of SDG appear to translate to a number of positive health benefits in a multitude of diseases, including diabetes, cancer, and cardiovascular disease [ 37 , 38 ]. SDG exhibited positive effects in a variety of model systems, including antioxidant effects in cadmium-induced renal toxicity in rats [ 41 ], anti-inflammatory effects in the dextran sulfate sodium salt-induced colitis mouse model [ 42 ], and cytoprotective and anti-inflammatory effects in human umbilical vein endothelial cells [ 43 ]. SDG and enterodiol have shown apoptotic effects on cultured human colon carcinoma cells [ 44 ] and colorectal cancer cells in vitro [ 45 ], respectively.…”

Section: Discussionmentioning

confidence: 99%

Feeding Fiber-Bound Polyphenol Ingredients at Different Levels Modulates Colonic Postbiotics to Improve Gut Health in Dogs

Jewell

Jackson

Cochrane

et al. 2022

Animals

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This study assessed changes in canine fecal metabolites and microbiota with the consumption of foods with increasing concentrations of a fiber bundle including pecan shells, flax seed, and powders of cranberry, citrus, and beet that was previously shown (at 14% w/w) to improve stool quality, shift fecal bacterial metabolism from proteolysis to saccharolysis, increase abundance of saccharolytic bacteria, and decrease abundance of proteolytic bacteria. In this study, 48 healthy adult dogs were split evenly to consume different inclusion levels (0%, 1%, 2%, and 4%) of the fiber bundle for a 31-day period following a 28-day pre-feed period. Increases from baseline in the fecal short-chain fatty acids butyric acid, valeric acid, and hexanoic acid were observed only in the dogs that consumed the food with the 4% fiber bundle. With addition of any level of the fiber bundle, increases were seen in the polyphenols hesperidin, hesperetin, ponciretin, secoisolariciresinol diglucoside, secoisolariciresinol, and enterodiol. However, fecal microbiota and their metabolism, and stool scores were largely unaffected by the fiber bundle. Overall, addition of the fiber bundle appeared to increase bioactive metabolites of increased antioxidant and anti-inflammatory potency for beneficial to health and, at levels ≥4%, shifted gut bacterial metabolism toward saccharolysis.

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Section: Discussionmentioning

confidence: 99%

Feeding Fiber-Bound Polyphenol Ingredients at Different Levels Modulates Colonic Postbiotics to Improve Gut Health in Dogs

Jewell

Jackson

Cochrane

et al. 2022

Animals

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“…Both in vivo and in vitro studies have provided plenty of evidence of oxidative stress playing an important role in Cd-induced nephrotoxicity, especially in tubular damage. Cd has been shown to enhance oxidative stress by triggering ROS production and inhibiting the antioxidant system in renal tubular epithelial cells; such oxidative damage and nephrotoxicity could be alleviated by various substances with antioxidant activity (Ognjanović et al, 2008;Wang et al, 2009Wang et al, , 2018Wang et al, , 2019Nazima et al, 2015;Poontawee et al, 2016;Das et al, 2019;Joardar et al, 2019;Aqeel et al, 2020). Cd is a nonredox metal; thus, it is not able to directly produce free radicals, but it indirectly increases the generation of ROS and causes oxidative stress damage (Liu et al, 2008).…”

Section: Ke1: Oxidative Stressmentioning

confidence: 99%

Construction of Mode of Action for Cadmium-Induced Renal Tubular Dysfunction Based on a Toxicity Pathway-Oriented Approach

Zhang

Liu

et al. 2021

Front. Genet.

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Although it is recognized that cadmium (Cd) causes renal tubular dysfunction, the mechanism of Cd-induced nephrotoxicity is not yet fully understood. Mode of action (MOA) is a developing tool for chemical risk assessment. To establish the mechanistic MOA of Cd-induced renal tubular dysfunction, the Comparative Toxicogenomics Database (CTD) was used to obtain genomics data of Cd-induced nephrotoxicity, and Ingenuity® Pathway Analysis (IPA) software was applied for bioinformatics analysis. Based on the perturbed toxicity pathways during the process of Cd-induced nephrotoxicity, we established the MOA of Cd-induced renal tubular dysfunction and assessed its confidence with the tailored Bradford Hill criteria. Bioinformatics analysis showed that oxidative stress, DNA damage, cell cycle arrest, and cell death were the probable key events (KEs). Assessment of the overall MOA of Cd-induced renal tubular dysfunction indicated a moderate confidence, and there are still some evidence gaps to be filled by rational experimental designs.

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“…19 Previous studies on Ii did not investigate the components and the herbal efficacy comprehensively. As mentioned above, chemical characterization of Ii 17,20,21 has been reported, as well as preclinical studies of single ingredients [22][23][24][25][26] or aqueous extracts. 11,14,18,19 However, there is still a need to elucidate the pharmacodynamic material basis of Ii in a more comprehensive manner.…”

Section: Introductionmentioning

confidence: 99%

A Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-Inflammatory and Anti-Viral Effect of Isatis indigotica

Deng

et al. 2021

DDDT

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Isatis indigotica (Ii) is a cruciferous herb that is widely distributed in China, and its roots and leaves have been used in two renowned antipyretic detoxicate crude drugs in Chinese Pharmacopoeia, Radix (R) and Folium (F) Isatidis. However, the pharmacodynamic material basis and underlying mechanisms of the herbal efficacy remained to be elucidated. Methods: Ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was adopted for the chemical profiling of R and F Isatidis. The active ingredients were screened out through the prediction of gastrointestinal absorption and druglikeness analysis using SwissADME. A herb-ingredient-target network was constructed through target prediction of the herbal active ingredients and anti-inflammation or anti-viral properties, followed by protein-protein interaction analysis. Then, the potential relevant signaling pathways were predicted by pathway enrichment. Finally, for verification, RAW 264.7 cell line was adopted to examine the anti-inflammatory and anti-viral activities of 6 representative ingredients in Ii. Results: Seventy-three compounds have been identified from Ii through UPLC-Q-TOF-MS. A total of 17 potential active ingredients were screened through pharmacokinetics and druglikeness evaluation using SwissADME. It was shown that key targets might include TNF, AKT1, SRC, IL2, CASP9, and CASP3 in our herb-ingredient-target network, and isovitexin, a flavonoid, tended to participate in the inflammatory response, indoles were more likely to affect the cell proliferation processes, and lignans might have a broader affinity to key targets than the other active ingredients, such as regulating immune system (targeting IL-2) and PI3K-Akt signaling pathway. In vitro, indigo and secoisolariciresinol diglucoside markedly reduced TNF-α expression in Poly (I: C)-incubated cells. Isovitexin significantly inhibited TNF-α expression, and isatin treatment markedly reduced IL-1β expression in LPS-incubated cells. Conclusion:As the pharmacodynamics material basis of Ii, indoles, lignans, and flavonoids are believed to confer beneficial properties through various cellular aspects with multiple signaling pathways involved.

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Secoisolariciresinol diglucoside protects against cadmium-induced oxidative stress-mediated renal toxicity in rats

Cited by 18 publications

References 36 publications

Feeding Fiber-Bound Polyphenol Ingredients at Different Levels Modulates Colonic Postbiotics to Improve Gut Health in Dogs

Feeding Fiber-Bound Polyphenol Ingredients at Different Levels Modulates Colonic Postbiotics to Improve Gut Health in Dogs

Construction of Mode of Action for Cadmium-Induced Renal Tubular Dysfunction Based on a Toxicity Pathway-Oriented Approach

A Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-Inflammatory and Anti-Viral Effect of Isatis indigotica

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