Secoisolariciresinol diglucoside mitigates benzo[a]pyrene-induced liver and kidney toxicity in mice via miR-101a/MKP-1-mediated p38 and ERK pathway

Ge, Junlin; Hao, Rili; Xue, Rong; Dou, Q. Ping; Tan, Xiao Di; Li, Guannan; Li, Feng

doi:10.1016/j.fct.2021.112733

Cited by 12 publications

(11 citation statements)

References 47 publications

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“…In various models of pathological states, SDG showed cytoprotective effect by reversing AMPK and mitogen-activated protein kinase phosphatase 1 (MKP-1) expression that restored the activity of antioxidant enzymes (SOD, CAT, GPx, GR, and peroxidase (POX)). It decreased pro-apoptotic protein levels, suppressed pro-inflammatory signaling (p-p38 MAPK, p-ERK, NF-κB) and the expression of inflammatory mediators (TNF-α, IL-10, interferon γ (IF-γ), MMP-2/9) [ 149 , 150 ]. SDG showed cytoprotective effect in cardiac iron overload-induced redox-inflammatory damage condition suggesting the cardioprotective role for this flaxseed lignan [ 73 ].…”

Section: Lignans With Antioxidant and Anti-inflammatory Actionmentioning

confidence: 99%

“…In in vivo models of CCl 4 and benzo[a]pyrene intoxication, SDG attenuated oxidative damage in liver and kidney tissues [ 72 ]. Additionally, SDG protected kidneys from cadmium-induced oxidative damage by restoring antioxidant enzymes activity and decreasing lipid peroxidation [ 148 , 149 ]. SDG showed protective effect against oxidative stress in rats with metabolic syndrome by preventing lipids from oxidative damage, improving enzymatic antioxidant defenses and GSH level [ 145 ].…”

Section: Lignans With Antioxidant and Anti-inflammatory Actionmentioning

confidence: 99%

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Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities

Osmakov

Kalinovskii

Belozerova

et al. 2022

IJMS

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Plant lignans exhibit a wide range of biological activities, which makes them the research objects of potential use as therapeutic agents. They provide diverse naturally-occurring pharmacophores and are available for production by chemical synthesis. A large amount of accumulated data indicates that lignans of different structural groups are apt to demonstrate both anti-inflammatory and antioxidant effects, in many cases, simultaneously. In this review, we summarize the comprehensive knowledge about lignan use as a bioactive agent in disorders associated with oxidative stress and inflammation, pharmacological effects in vitro and in vivo, molecular mechanisms underlying these effects, and chemical synthesis approaches. This article provides an up-to-date overview of the current data in this area, available in PubMed, Scopus, and Web of Science databases, screened from 2000 to 2022.

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Section: Lignans With Antioxidant and Anti-inflammatory Actionmentioning

confidence: 99%

Section: Lignans With Antioxidant and Anti-inflammatory Actionmentioning

confidence: 99%

Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities

Osmakov

Kalinovskii

Belozerova

et al. 2022

IJMS

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“…SDG targets the MIR101A/MKP-1 axis to downregulate p-ERK and p-p38 levels, thereby regulating oxidative stress and inflammation. This protected the kidney and liver of mice against BaP toxicity [ 71 ].…”

Section: Microrna Related To the Mapk Signaling Pathway In Liver Cancermentioning

confidence: 99%

Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer

Wang

Feng

Tang

2022

IJMS

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The advancement in high-throughput sequencing analysis and the evaluation of chromatin state maps have revealed that eukaryotic cells produce many non-coding transcripts/RNAs. Further, a strong association was observed between some non-coding RNAs and cancer development. The mitogen-activated protein kinases (MAPK) belong to the serine–threonine kinase family and are the primary signaling pathways involved in cell proliferation from the cell surface to the nucleus. They play an important role in various human diseases. A few non-coding RNAs associated with the MAPK signaling pathway play a significant role in the development of several malignancies, including liver cancer. In this review, we summarize the molecular mechanisms and interactions of microRNA, lncRNA, and other non-coding RNAs in the development of liver cancer that are associated with the MAPK signaling pathway. Further, we briefly discuss the therapeutic strategies for liver cancer related to ncRNA and the MAPK signaling pathway.

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“…Real-time PCR was performed using a SYBR Green kit (Tiangen, Beijing, China) on a CFX connect thermocycler system (Bio-Rad, Shanghai, China) according to the manufacturer’s protocol. The relative mRNA expression levels were calculated based on the comparative threshold cycle (Ct) value, applying the 2 −ΔΔCt method, as previously reported [ 31 ]. The relative quantification was normalized to GAPDH.…”

Section: Methodsmentioning

confidence: 99%

Alanyl-Glutamine Protects against Lipopolysaccharide-Induced Liver Injury in Mice via Alleviating Oxidative Stress, Inhibiting Inflammation, and Regulating Autophagy

Ying

Zheng

et al. 2022

Antioxidants

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Acute liver injury is a worldwide problem with a high rate of morbidity and mortality, and effective pharmacological therapies are still urgently needed. Alanyl-glutamine (Ala-Gln), a dipeptide formed from L-alanine and L-glutamine, is known as a protective compound that is involved in various tissue injuries, but there are limited reports regarding the effects of Ala-Gln in acute liver injury. This present study aimed to investigate the protective effects of Ala-Gln in lipopolysaccharide (LPS)-induced acute liver injury in mice, with a focus on inflammatory responses and oxidative stress. The acute liver injury induced using LPS (50 μg/kg) and D-galactosamine (D-Gal) (400 mg/kg) stimulation in mice was significantly attenuated after Ala-Gln treatment (500 and 1500 mg/kg), as evidenced by reduced plasma alanine transaminase (ALT) (p < 0.01, p < 0.001), aspartate transaminase (AST) (p < 0.05, p < 0.001), and lactate dehydrogenase (LDH) (p < 0.01, p < 0.001) levels, and accompanied by improved histopathological changes. In addition, LPS/D-Gal-induced hepatic apoptosis was also alleviated by Ala-Gln administration, as shown by a greatly decreased ratio of TUNEL-positive hepatocytes, from approximately 10% to 2%, and markedly reduced protein levels of cleaved caspase-3 (p < 0.05, p < 0.001) in liver. Moreover, we found that LPS/D-Gal-triggered oxidative stress was suppressed after Ala-Gln treatment, the effect of which might be dependent on the elevation of SOD and GPX activities, and on GSH levels in liver. Interestingly, we observed that Ala-Gln clearly inhibited LPS/D-Gal exposure-induced macrophage accumulation and the production of proinflammatory factors in the liver. Furthermore, Ala-Gln greatly regulated autophagy in the liver in LPS/D-Gal-treated mice. Using RAW264.7 cells, we confirmed the anti-inflammatory role of Ala-Gln-targeting macrophages.

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Secoisolariciresinol diglucoside mitigates benzo[a]pyrene-induced liver and kidney toxicity in mice via miR-101a/MKP-1-mediated p38 and ERK pathway

Cited by 12 publications

References 47 publications

Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities

Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities

Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer

Alanyl-Glutamine Protects against Lipopolysaccharide-Induced Liver Injury in Mice via Alleviating Oxidative Stress, Inhibiting Inflammation, and Regulating Autophagy

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