Secoiridoids and hydroxycoumarins in Bulgarian Fraxinus species

Iossifova, Tanya; Kostova, I.; Evstatieva, L.

doi:10.1016/s0305-1978(97)00006-9

Cited by 16 publications

(13 citation statements)

References 8 publications

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“…insularoside). Both secoiridoids are characteristic only of Fraxinus ornus and showed that sample 6 was wrongly assigned as Fraxinus excelsior leaf.…”

Section: Resultsmentioning

confidence: 99%

“…15,16 The secoiridoids present in this genera are typical of the Oleaceae family: oleuropein, ligstroside and 10-hydroxyligstroside, along with the less common excelsioside and dimer GI5. 15,[17][18][19] Verbascoside/acteoside is the main phenylethanoid in leaves. 17 Seeds/fruits are characterised by the presence of dimeric secoiridoids: nuzhenide and GI3.…”

Section: Introductionmentioning

confidence: 99%

“…esculetin, scopoletin, fraxetin, fraxinol) and their glycosides were identified in the bark, while the leaves may contain coumarins as minor compounds . The secoiridoids present in this genera are typical of the Oleaceae family: oleuropein, ligstroside and 10‐hydroxyligstroside, along with the less common excelsioside and dimer GI5 . Verbascoside/acteoside is the main phenylethanoid in leaves .…”

Section: Introductionmentioning

confidence: 99%

“…In the case of the raw material, the distinction using thin layer chromatography (TLC) is feasible only for adulteration with manna ash leaf, which is observed as the presence of several light blue or blue fluorescent zones . Its presence is connected with hydroxycoumarins such as esculin and esculetin, which are dominating compounds in manna ash leaves …”

Section: Introductionmentioning

confidence: 99%

“…14 Its presence is connected with hydroxycoumarins such as esculin and esculetin, which are dominating compounds in manna ash leaves. 15 The presence of secoiridoids, phenylethanoids and coumarins is a characteristic feature of Fraxinus species, especially the occurrence of coumarins that distinguish the genus Fraxinus from the other genera in Oleaceae. 16 In Fraxinus excelsior, almost 15 different coumarins (e.g.…”

Section: Introductionmentioning

confidence: 99%

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UHPLC‐DAD‐ESI‐MS/MS and HPTLC profiling of ash leaf samples from different commercial and natural sources and their in vitro effects on mediators of inflammation

Kiss

Michalak

Patyra

et al. 2019

Phytochemical Analysis

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Introduction In European traditional medicine, common ash leaf infusion is recommended by European Medicines Agency to treat minor articular pain and to increase the amount of urine for flushing minor urinary complaints. However, a comprehensive ultra‐high‐performance liquid chromatography diode array detector electrospray ionisation tandem mass spectrometry (UHPLC‐DAD‐ESI‐MS/MS) analysis of this pharmacopeial plant material has never been performed. Moreover, the number of biological and pharmacological investigations proving the usefulness of this plant material in recommended traditional uses is surprisingly small. Objective Phytochemical profiling of ash leaf samples from different commercial and natural sources and the determination of the in vitro effects on inflammatory mediators in a model of human neutrophils. Methods Ash leaf samples were characterised by total hydroxycinnamic acid content and by high‐performance thin layer chromatography (HPTLC), UHPLC‐DAD‐ESI‐MS/MS methods. The effects of leaf infusions on reactive oxygen species (ROS), tumor necrosis factor (TNF‐α), interleukin 8 (IL‐8), interleukin 1β (IL‐1β), and monocyte chemoattractant protein 1 (MCP‐1) production by neutrophils were measured using luminol‐dependent chemiluminescence and enzyme‐linked immunosorbent assay (ELISA). Results In ash leaf samples 64 compounds were identified or partly identified together with four unknown compounds. The major compounds detected belong to different structural groups, including phenolic acid derivatives, phenylethanoids, flavonoids, iridoids, secoiridoids and lignans. The major compounds detected in ash samples were chlorogenic acid, quercetin‐3‐O‐rutinoside, verbascoside, oleuropein and ligstroside. However, one sample contained coumarin derivatives. This finding suggested adulteration with other Fraxinus species and/or plant parts. All infusions were able to inhibit ROS, cytokine and chemokine production. Conclusions The performed phytochemical and biological analyses contribute to the knowledge about this pharmacopeial plant material and supports its traditional use to treat minor inflammatory complaints.

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“…insularoside). Both secoiridoids are characteristic only of Fraxinus ornus and showed that sample 6 was wrongly assigned as Fraxinus excelsior leaf.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

UHPLC‐DAD‐ESI‐MS/MS and HPTLC profiling of ash leaf samples from different commercial and natural sources and their in vitro effects on mediators of inflammation

Kiss

Michalak

Patyra

et al. 2019

Phytochemical Analysis

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Fraxiınus ornus L.

Eruygur

2022

Novel Drug Targets With Traditional Herbal Medicines

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Comparative Phloem Chemistry of Manchurian (Fraxinus mandshurica) and Two North American Ash Species (Fraxinus americana and Fraxinus pennsylvanica)

et al. 2007

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Recent studies have investigated interspecific variation in resistance of ash (Fraxinus spp.) to the exotic wood-boring beetle, emerald ash borer (EAB, Agrilus planipennis). Manchurian ash (Fraxinus mandshurica) is an Asian species that has coevolved with EAB. It experiences little EAB-induced mortality compared to North American ashes. Host phloem chemistry, both constitutive and induced, might partly explain this interspecific variation in resistance. We analyzed the constitutive phloem chemistry of three ash species: Manchurian ash and North American white (Fraxinus americana) and green (Fraxinus pennsylvanica) ash. Analysis of the crude phloem extracts revealed the presence of an array of phenolic compounds including hydroxycoumarins, a monolignol, lignans, phenylethanoids, and secoiridoids. Both qualitative and quantitative differences were observed among the three ash species. Hydroxycoumarins and the phenylethanoids, calceloariosides A and B, were present only in the phloem of Manchurian ash and might represent a mechanism of resistance against EAB.

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Secoiridoids and hydroxycoumarins in Bulgarian Fraxinus species

Cited by 16 publications

References 8 publications

UHPLC‐DAD‐ESI‐MS/MS and HPTLC profiling of ash leaf samples from different commercial and natural sources and their in vitro effects on mediators of inflammation

UHPLC‐DAD‐ESI‐MS/MS and HPTLC profiling of ash leaf samples from different commercial and natural sources and their in vitro effects on mediators of inflammation

Fraxiınus ornus L.

Comparative Phloem Chemistry of Manchurian (Fraxinus mandshurica) and Two North American Ash Species (Fraxinus americana and Fraxinus pennsylvanica)

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