SEC61G identified as a prognostic biomarker of head and neck squamous cell carcinoma

Abstract

Purpose It is of obvious interest to identify clinical prognosis-related oncogenes in HNSCC (head and neck squamous cell carcinoma). Methods Based on the available datasets within the TCGA (The Cancer Genome Atlas) and the GEO (Gene Expression Omnibus) databases, the potential mechanism of action of the SEC61G (SEC61 translocon subunit gamma) gene in HNSCC tumorigenesis was explored by several bioinformatics approaches. Results There was a higher expression level of SEC61G in primary HNSCC tumor tissues than in normal tissues. Moreover, highly expressed SEC61G was statistically associated with the poor survival prognosis of HNSCC patients. When HPV (human papilloma virus) was considered, we also observed a relatively lower proportion of “arm-level gain” and “high amplification” types of CNA (copy-number alteration) in the HNSCC-HPV (+) group than in the HNSCC-HPV (−) group. Additionally, we identified SEC61G CAN-correlated genes, such as CCT6A (chaperonin-containing TCP1 subunit 6A) and HUS1 (HUS1 checkpoint clamp component), and found a correlation between SEC61G copy-number segments and prognosis related to overall and progression-free survival intervals of HNSCC patients. Moreover, the molecular regulation mechanisms of the spliceosome, ribosome, proteasome degradation, cell adhesion, and immune infiltration of B and CD8+ T cells may contribute to the involvement of SEC61G in the pathogenesis of HNSCC. Conclusions The SEC61G gene was identified for the first time as a prognostic biomarker of HNSCC. The detailed underlying mechanism merits further research.

SEC61 translocon subunit gamma enhances low-dose cisplatin-induced cancer-stem cell properties of head and neck squamous cell carcinoma via enhancing Ca2+-mediated autophagy

“… 12 In HNSCC, SEC61G is a highly amplified gene and might be a biomarker of poor prognosis. 14 , 27 This prognostic significance was also verified in the current study based on data from TCGA. However, the underlying tumor-promoting mechanisms of SEC61G have not been explored yet.…”

Identification of SEC61G as a Diagnostic and Prognostic Biomarker in Oral Squamous Cell Carcinoma

“…This correlation suggests that elevated SEC61G expression may serve as a potential pro-oncogenic marker in OSCC, indicating a more aggressive phenotype of the disease. These findings were also supported by two additional studies conducted on SEC61G in head and neck squamous cell carcinomas (HNSCC) [22,23]. Compared to these two studies, in addition to the bioinformatics research, our study conducted more comprehensive analyses of the clinical samples of patients with OSCC.…”

Characterization of a prognostic model for head and neck squamous cell carcinoma based on Telomere maintenance genes

“…MYF6, located on chromosome 12q21, contributes to muscle differentiation and has been observed to undergo hypermethylation in the early stages of nonsmall cell lung cancer 40 . Furthermore, MYF6 and CCT6A play a crucial role in tumor immunity or prognosis of HNSCC 41,42 .…”