SEBS elastomers for fabrication of microfluidic devices with reduced drug absorption by injection molding and extrusion

Domanský, Karel; Sliz, Josiah; Wen, Norman; Hinojosa, Christopher D.; Thompson, G. W.; Fraser, Jacob P.; Hamkins-Indik, Tiama; Hamilton, Geraldine A.; Levner, Daniel; Ingber, Donald E.

doi:10.1007/s10404-017-1941-4

Cited by 68 publications

(71 citation statements)

References 31 publications

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“…Although PDMS holds many favorable properties for manufacturing microfluidic organ devices, it also has the potential drawback of adsorbing small and hydrophobic molecules. 61 , 62 To overcome this, surface modification of PDMS or alternative polymeric (eg, polyurethane, styrenic block copolymers) 63 or ECM-based materials 64 could potentially be used in studies designed to predict drug bioavailability or absorption. Alternatively, when using Organ Chips to model drug PK and PD, PDMS adsorption can be taken into account using computational modeling for most compounds.…”

Section: Limitations Of Human Intestine Chip Modelsmentioning

confidence: 99%

Microfluidic Organ-on-a-Chip Models of Human Intestine

Bein

Shin

Baharvand

et al. 2018

Cellular and Molecular Gastroenterology and Hepatology

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452

329

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Microfluidic organ-on-a-chip models of human intestine have been developed and used to study intestinal physiology and pathophysiology. In this article, we review this field and describe how microfluidic Intestine Chips offer new capabilities not possible with conventional culture systems or organoid cultures, including the ability to analyze contributions of individual cellular, chemical, and physical control parameters one-at-a-time; to coculture human intestinal cells with commensal microbiome for extended times; and to create human-relevant disease models. We also discuss potential future applications of human Intestine Chips, including how they might be used for drug development and personalized medicine.

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Section: Limitations Of Human Intestine Chip Modelsmentioning

confidence: 99%

Microfluidic Organ-on-a-Chip Models of Human Intestine

Bein

Shin

Baharvand

et al. 2018

Cellular and Molecular Gastroenterology and Hepatology

Self Cite

452

329

View full text Add to dashboard Cite

show abstract

“…Further advancement needs to be made in terms of recapitulating both healthy and diseased tissues. This may be further promoted by materials' development, such as finding substitutes for PDMS . While PDMS is clear, flexible, heat resistant, and enables gas exchange, it can absorb hydrophobic substances and can interact with polar compounds .…”

Section: Microfluidic In Vitro Systems: the Isocmentioning

confidence: 99%

Models of the Gut for Analyzing the Impact of Food and Drugs

Fois

Schindeler

et al. 2019

Adv Healthcare Materials

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The human intestine is the primary organ responsible for the uptake of nutrients and water, and this is facilitated by its complex structure that features a large surface area. With an average total length of around seven meters, including both small and large intestine, it connects the stomach to the rectum while enabling absorption in a specialized manner. At a cellular level, the gut epithelium is critical in selective transport to the bloodstream. The finger-like projections of the intestinal epithelium Models of the human gastrointestinal tract (GIT) can be powerful tools for examining the biological interactions of food products and pharmaceuticals. This can be done under normal healthy conditions or using models of disease-many of which have no curative therapy. This report outlines the field of gastrointestinal modeling, with a particular focus on the intestine. Traditional in vivo animal models are compared to a range of in vitro models. In vitro systems are elaborated over time, recently culminating with microfluidic intestines-on-chips (IsOC) and 3D bioengineered models. Macroscale models are also reviewed for their important contribution in the microbiota studies. Lastly, it is discussed how in silico approaches may have utility in predicting and interpreting experimental data. The various advantages and limitations of the different systems are contrasted. It is posited that only through complementary use of these models will salient research questions be able to be addressed.

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“…OSTEs thiol-ene ratios can also be tuned to allow fabrication of flexible devices and thus produce mechanically actuated components (Carlborg et al, 2011). Other materials, intended as a bridge between PDMS and thermoplastics in terms of high-throughput fabrication and material characteristics, are styrene-ethylene-butylene-styrene (SEBS) block copolymers (Domansky et al, 2017). For biomedical applications, the focus has shifted from PDMS-like materials towards bio-based materials such as silk and hydrogels, due to their biodegradability and surface and topographical properties (Konwarh et al, 2016), (Zhao et al, 2016).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“Connecting worlds – a view on microfluidics for a wider application”

Fernandes

Gernaey

Krühne

2018

Biotechnology Advances

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From its birth, microfluidics has been referenced as a revolutionary technology and the solution to long standing technological and sociological issues, such as detection of dilute compounds and personalized healthcare. Microfluidics has for example been envisioned as: (1) being capable of miniaturizing industrial production plants, thereby increasing their automation and operational safety at low cost; (2) being able to identify rare diseases by running bioanalytics directly on the patient's skin; (3) allowing health diagnostics in point-of-care sites through cheap lab-on-a-chip devices. However, the current state of microfluidics, although technologically advanced, has so far failed to reach the originally promised widespread use. In this paper, some of the aspects are identified and discussed that have prevented microfluidics from reaching its full potential, especially in the chemical engineering and biotechnology fields, focusing mainly on the specialization on a single target of most microfluidic devices and offering a perspective on the alternate, multi-use, "plug and play" approach. Increasing the flexibility of microfluidic platforms, by increasing their compatibility with different substrates, reactions and operation conditions, and other microfluidic systems is indeed of surmount importance and current academic and industrial approaches to modular microfluidics are presented. Furthermore, two views on the commercialization of plug-and-play microfluidics systems, leading towards improved acceptance and more widespread use, are introduced. A brief review of the main materials and fabrication strategies used in these fields, is also presented. Finally, a step-wise guide towards the development of microfluidic systems is introduced with special focus on the integration of sensors in microfluidics. The proposed guidelines are then applied for the development of two different example platforms, and to three examples taken from literature. With this work, we aim to provide an interesting perspective on the field of microfluidics when applied to chemical engineering and biotechnology studies, as well as to contribute with potential solutions to some of its current challenges.

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SEBS elastomers for fabrication of microfluidic devices with reduced drug absorption by injection molding and extrusion

Cited by 68 publications

References 31 publications

Microfluidic Organ-on-a-Chip Models of Human Intestine

Microfluidic Organ-on-a-Chip Models of Human Intestine

Models of the Gut for Analyzing the Impact of Food and Drugs

“Connecting worlds – a view on microfluidics for a wider application”

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