Seborrheic keratosis with possible central regression

Yamamoto, K.

doi:10.1097/00006534-199102000-00079

Cited by 2 publications

(5 citation statements)

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“…Seborrheic keratoses are usually asymptomatic and there is little tendency to spontaneous regression. However, some lesions become inflamed or irritated and may occasionally disappear with postinflammatory pigmentation 2,3 . Spontaneous complete or partial regression of some cutaneous neoplasms such as malignant melanoma, 4 basal cell carcinoma, 5 Merkel cell carcinoma, 6,7 and Bowen's disease 8,9 has been reported.…”

Section: Reportmentioning

confidence: 99%

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Spontaneous regression of multiple seborrheic keratoses associated with nasal carcinoma

Furue

Kohda

Duan

et al. 2001

Clinical and Experimental Dermatology

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Seborrheic keratoses are very common epidermal neoplasms. We describe a patient with seborrheic keratoses presenting multifocal spontaneous regression. The patient had a concurrent nasal adenoid cystic carcinoma. The simultaneous regression of seborrheic keratoses ceased after total resection of the nasal carcinoma. Histological examination revealed marked infiltration of mononuclear cells, including CD4+, CD8+, CD68+ and cutaneous lymphocyte-associated antigen-positive cells, with profound accumulation of CD1a+ dendritic cells. Although apoptotic keratinocytes were not found in the lesional epidermis by histology, the majority of keratinocytes in the regressing seborrheic keratosis were positively stained by the TUNEL method. We postulate that the internal malignancy may induce spontaneous regression of seborrheic keratoses.

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Section: Reportmentioning

confidence: 99%

“…Berman et al 2 . and Yamamoto et al 3 . emphasized the importance of mononuclear cell infiltration in regressing seborrheic keratoses; however, precise immunophenotyping has not been performed.…”

Section: Reportmentioning

confidence: 99%

Spontaneous regression of multiple seborrheic keratoses associated with nasal carcinoma

Furue

Kohda

Duan

et al. 2001

Clinical and Experimental Dermatology

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“…Dylon staining revealed amyloid deposition (k, 9100), which was also positive for pan-cytokeratin (l, 9200) Regression of seborrheic keratosis is rare. [1][2][3] In cases of internal malignancy, multiple seborrheic keratoses, known as the Leser-Trel at sign, showed a tendency to regress after surgical resection of the malignancy. 1,2 Histological characteristic of the regressing seborrheic keratosis is prominent mononuclear cell infiltration.…”

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confidence: 99%

“…[1][2][3] In cases of internal malignancy, multiple seborrheic keratoses, known as the Leser-Trel at sign, showed a tendency to regress after surgical resection of the malignancy. 1,2 Histological characteristic of the regressing seborrheic keratosis is prominent mononuclear cell infiltration. [1][2][3] By contrast, our cases developed solitary lesions unassociated with the Leser-Trel at sign, and most or part of the keratotic lesions fell off spontaneously.…”

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confidence: 99%

“…1,2 Histological characteristic of the regressing seborrheic keratosis is prominent mononuclear cell infiltration. [1][2][3] By contrast, our cases developed solitary lesions unassociated with the Leser-Trel at sign, and most or part of the keratotic lesions fell off spontaneously. In Case 1, the patient said that the nodule on the scalp had spontaneously decreased in size.…”

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