Seborrheic keratosis mimicking basal cell carcinoma under dermoscopy: a case report

Gao, Yingying; An, Xiang-jie; Yang, Jing Bo; Huang, Changzheng; Tao, Juan

doi:10.1097/cm9.0000000000001010

Cited by 5 publications

(5 citation statements)

References 5 publications

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“…Dermoscopy is a useful tool toward this discrimination. However, if any diagnostic doubts are present, excision and histologic examination with immunohistochemistry is highly recommended 30,31 . A recent study indicated that combining the U3 small nucleolar ribonucleoprotein protein IMP3 with the B‐cell lymphoma 2 regulatory protein (Bcl‐2) was protective 32 …”

Section: Pathogenesismentioning

confidence: 99%

Update of pathophysiology and treatment options of seborrheic keratosis

Gorai¹,

Ahmad

Raza

et al. 2022

Dermatologic Therapy

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Seborrheic keratosis (SK) is a common, benign tumor that can occur on everybody site and can be conservatively managed. Cosmetic concerns, especially when a lesion involves the facial area, are the most common reason for excision. SK shows male gender preponderance and increasing age is an independent association with the condition. Even though more prevalent in the elderly, it has also been reported in younger age groups like adolescents and young adults. Precise pathogenesis is still obscure, but ultra-violet exposure represents a predisposing factor to SK by altering the biochemical concentration and expression of factors like Glutamine deaminases, endothelin, and stem cell factor. Moreover, the accumulation of amyloid-associated protein has also been postulated. Involvement of genitalia has been associated with human papillomavirus infection. Recently, Merkel cell polyomavirus nucleic acid was also detected in SK. Several oncogenic mutations involving FGFR-3 and FOXN1 have been identified. SKs are usually classified clinically and histologically. Dermatoscopy is a noninvasive alternative diagnostic technique widely used in differentiating SK from other benign and malignant tumors. In terms of treatment, topical agents, shave dissection, cryosurgery, electrodesiccation, laser application and curettage under local anesthesia are safe methods for eradication of SKs, mostly for cosmetic purposes. Though generally safe, the latter techniques may occasionally cause postprocedure depigmentation, scarring, and recurrence. Nanosecond-pulsed electric field technology is a promising new technique with fewer side-effects.

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Section: Pathogenesismentioning

confidence: 99%

Update of pathophysiology and treatment options of seborrheic keratosis

Gorai¹,

Ahmad

Raza

et al. 2022

Dermatologic Therapy

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“…28 Apart from this specific histopathologic variant, the ability of SKs to mimic BCC has been only anecdotally reported. 29 Regarding vascular structures, the vast majority (91.3%) of the iSKs in our series showed vessels on dermoscopy. Overall, 40.6% of lesions in our series showed hairpin vessels as the predominant type.…”

Section: Discussionmentioning

confidence: 63%

“…Due to the presence of bluish globular‐like structures, previous studies specifically reported that clonal SKs can mimic BCC 28 . Apart from this specific histopathologic variant, the ability of SKs to mimic BCC has been only anecdotally reported 29 …”

Section: Discussionmentioning

confidence: 99%

Dermoscopy of inflamed seborrheic keratosis: A great mimic of malignancy

et al. 2021

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Background: Clinical and dermoscopic recognition of seborrheic keratoses (SKs) is often straightforward, and biopsy might not be required. However, inflamed SKs (iSKs) can pose a diagnostic challenge. Dermoscopic features of iSKs have not yet been evaluated to date.Objectives: To assess the diagnostic ability of a group of dermatologists to diagnose iSKs by dermoscopy. To evaluate the dermoscopic findings of a long series of inflamed seborrheic keratoses.Methods: Clinical and dermoscopic images of 100 difficult-to-diagnose skin tumours, including 29 iSKs, were presented to 33 clinicians (24 dermatologists and 9 dermatology residents), who were blinded to the diagnosis. The dermoscopic features of a series of 219 iSKs were retrospectively analysed.Results: iSKs were correctly identified in a 37.6% of cases. Classic dermoscopic criteria were present in only 47% of iSKs. The most frequent dermoscopic feature in iSKs was the presence of vascularization (91.3%), but only a 44.5% showed predominance of hairpin vessels. A bluish hue was observed in 18.3% of lesions. Seven dermoscopic patterns were identified, based on the dermoscopic similarity to other tumours: seborrheic keratosis-like (28.8%); squamous cell carcinoma-like (25.6%); melanoma-like (17.8%); keratoacanthoma-like (6.8%); basal cell carcinoma-like (5.9%); verruca vulgaris-like (5.9%); nevus-like (2.3%). Conclusions:The diagnosis of iSKs can be challenging even with dermoscopy. They may behave as authentic mimics of other cutaneous tumours, including squamous cell carcinoma or melanoma. For this reason, histopathological examination should be mandatory in these cases.

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“… 24 , 25 However, BCC may clinically and dermoscopically resemble a SK and vice versa. 26 , 27 A retrospective study on histologically confirmed BCCs of the lower limbs showed that they frequently simulate other benign or malignant lesions. Seborrheic keratosis-like BCC exhibited hairpin vessels, white-pink areas as well as multiple blue-grey dots and granularity that may be present in regressive SK (lichenoid keratosis, see later).…”

Section: Dermoscopic Mimics Of Skmentioning

confidence: 99%

Differential Diagnosis and Management on Seborrheic Keratosis in Elderly Patients

Moscarella¹,

Brancaccio²,

Briatico³

et al. 2021

CCID

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Seborrheic keratoses are exceedingly common in the elderly and usually are easy to diagnose and do not require treatment. However, given their great variety of clinical presentation, they may give rise to false-positive cases, meaning that they may at times mimic melanoma, squamous cell carcinoma and basal cell carcinoma. On the other hand, melanoma may mimic seborrheic keratosis, leading to incorrect patient management. With this review, we would like to summarize the current knowledge about epidemiology, clinical, dermoscopic and reflectance confocal microscopy imaging of this common entity, and we also summarize the currently available treatment options.

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Seborrheic keratosis mimicking basal cell carcinoma under dermoscopy: a case report

Cited by 5 publications

References 5 publications

Update of pathophysiology and treatment options of seborrheic keratosis

Update of pathophysiology and treatment options of seborrheic keratosis

Dermoscopy of inflamed seborrheic keratosis: A great mimic of malignancy

Differential Diagnosis and Management on Seborrheic Keratosis in Elderly Patients

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