Seborrheic Keratoses

Reiches, A. J.

doi:10.1001/archderm.1952.01530240088011

Cited by 24 publications

(5 citation statements)

References 5 publications

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“…The lesions are usually asymptomatic, but may be itchy. [2] Although there are many clinical variants of the lesions, these lesions usually begin as well-circumscribed, dull, flat, tan, or brown patches. As they grow, they become more papular, taking on a waxy verrucous or “stuck-on” appearance.…”

Section: Introductionmentioning

confidence: 99%

A clinicopathological and dermoscopic correlation of seborrheic keratosis

2016

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Background:Seborrheic keratosis (SK) is the most common benign epidermal tumor of the skin. Even though SK has been well characterized clinically, dermoscopically, and histopathologically, data regarding clinical dermoscopic and histopathological correlation of different types of SK are inadequate.Aim:We carried out this study to establish any correlation between the clinical, dermoscopic, and histopathological appearance of SK and its variants.Methods:This was a descriptive study. Patients with SK were evaluated with respect to age, sex, family history of similar lesions, site of lesions, and symptoms associated with the lesions. Dermoscopy was performed in all cases. Biopsies were taken from the lesions and assessed for histopathology.Results:The most common age group affected by SK was 31–50 years (42%). A female preponderance of 76% was seen. Majority of our patients had a positive family history (62%), though Sun exposure was not seen to be a major factor. The most common clinical variant was common SK (CSK) (46%). The most common dermoscopic findings seen in CSK were comedo-like (CL) openings, fissures and ridges (FR), and milia-like (ML) cysts. Dermatosis papulosa nigra and pedunculated SK had characteristic FR and CL openings on dermoscopy. Stucco keratoses showed network-like (NL) structures and sharp demarcation. CL opening on dermoscopy corresponded to papillomatosis and pigmentation, ML cysts corresponded to horn cysts, FR corresponded to papillomatosis, and NL structures corresponded to an increase in basal layer pigmentation.Conclusions:This study emphasizes the use of dermoscopy in improving the diagnostic accuracy of SK. The correlation between the various histological and dermoscopic features is described.

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Section: Introductionmentioning

confidence: 99%

A clinicopathological and dermoscopic correlation of seborrheic keratosis

2016

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“…As early as 1952, Reiches identified an autosomal-dominant inheritance pattern of SK in several families in which the lesions occurred over three generations. 30 Other clinical case reports noted families in which there was an increased incidence of SK over several generations, also at an unusually young age. 1,31,32 Despite the clear association between genetics and the pathogenesis of SK, the precise mode of inheritance has not been conclusively determined.…”

Section: Risk Factorsmentioning

confidence: 98%

“…Genetic predisposition is certainly another risk factor for SK. As early as 1952, Reiches identified an autosomal‐dominant inheritance pattern of SK in several families in which the lesions occurred over three generations 30 . Other clinical case reports noted families in which there was an increased incidence of SK over several generations, also at an unusually young age 1,31,32 .…”

Section: Pathogenesismentioning

confidence: 99%

Seborrheic keratosis

Barthelmann¹,

Butsch²,

Lang³

et al. 2023

J Deutsche Derma Gesell

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Summary Seborrheic keratosis (SK) is the most common benign epidermal tumor in clinical dermatological practice. This review summarizes current knowledge about the clinical and histological appearance, epidemiology, pathogenesis, and treatment of SK. There are different subtypes of SK based on clinical presentation and histologic findings. Several factors, including age, genetic predisposition, and possibly also exposure to ultraviolet radiation, are thought to contribute to the development of SK. The lesions can occur on all areas of the body except for the palms and soles, but the most common sites are the face and upper trunk. The diagnosis is usually made clinically, and in some cases by dermatoscopy or histology. Many patients prefer to have the lesions removed for cosmetic reasons although there is no medical indication. Treatment options include surgical therapy, laser therapy, electrocautery, cryotherapy, and topical drug therapy, which is currently in development. Treatment should be individualized depending on the clinical picture and patient preference.

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“…Schon im Jahr 1952 stellte Reiches ein autosomal-dominantes Vererbungsmuster von SK in mehreren Familien fest, in denen die Läsionen über drei Generationen hinweg auftraten. 30 Weitere klinische Fallberichte zeigten Familien auf, in denen SK über mehrere Generationen hinweg gehäuft und auch in ungewöhnlich jungem Alter auftraten. 1,31,32 Trotz des eindeutigen Zusammenhangs zwischen Genetik und der Pathogenese von SK ist der genaue Vererbungsmodus nicht abschließend geklärt.…”

Section: äTiopathogenese Risikofaktorenunclassified

“…Sicherlich stellt auch die genetische Prädisposition einen Risikofaktor für die SK dar. Schon im Jahr 1952 stellte Reiches ein autosomal‐dominantes Vererbungsmuster von SK in mehreren Familien fest, in denen die Läsionen über drei Generationen hinweg auftraten 30 . Weitere klinische Fallberichte zeigten Familien auf, in denen SK über mehrere Generationen hinweg gehäuft und auch in ungewöhnlich jungem Alter auftraten 1,31,32 .…”

Section: äTiopathogeneseunclassified

Seborrhoische Keratosen

Barthelmann

Butsch

Lang

et al. 2023

J Deutsche Derma Gesell

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ZusammenfassungDie seborrhoische Keratose (SK) ist der häufigste gutartige epidermale Tumor in der klinisch‐dermatologischen Praxis. Diese Übersicht fasst den Kenntnisstand zu Klinik, Histologie, Epidemiologie, Pathogenese und Therapie von SK zusammen. Anhand des klinischen und histologischen Bildes unterscheidet man verschiedene Typen der SK. Es wird vermutet, dass mehrere Faktoren, darunter das Alter, eine genetische Prädisposition und möglicherweise auch die Exposition gegenüber ultravioletter Strahlung mit der Entstehung der Tumoren in Verbindung stehen. Die Läsionen können an allen Körperregionen auftreten, mit Ausnahme der Handflächen und Fußsohlen, die häufigsten Stellen sind jedoch das Gesicht und der obere Rumpf. Die Diagnose erfolgt meistens klinisch, in manchen Fällen unter Zuhilfenahme eines Dermatoskops oder durch Biopsie. Viele Patienten bevorzugen es, SK aus kosmetischen Gründen zu entfernen, obwohl keine medizinische Indikation hierzu vorliegt. Bei den Behandlungsmöglichkeiten wird zwischen chirurgischen, chirurgisch‐destruierenden (Laser, Elektrodesikkation/‐kaustik, Kryotherapie) und topisch‐medikamentösen Verfahren unterschieden. Letztere sind aktuell in klinischer Entwicklung. Die Behandlung wird abhängig vom klinischen Bild und der Präferenz des Patienten individuell angepasst.

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Seborrheic Keratoses

Cited by 24 publications

References 5 publications

A clinicopathological and dermoscopic correlation of seborrheic keratosis

A clinicopathological and dermoscopic correlation of seborrheic keratosis

Seborrheic keratosis

Seborrhoische Keratosen

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