Seborrheic dermatitis

Gupta, Aditya K.; Bluhm, Robyn

doi:10.1111/j.1468-3083.2004.00693.x

Cited by 233 publications

(255 citation statements)

References 173 publications

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“…are present on the skin surface and within layers of the stratum corneum, variations in technique in obtaining specimen and quantifying the organism likely explain the differences in findings among available studies (Gupta AK). M. globosa and M. restricta are commensal yeasts requiring an exogenous source of lipids and are most commonly associated with seborrheic dermatitis [10]. They are capable of degrading lipids in sebum with production of free fatty acids and triglycerides, followed by consumption of certain saturated fatty acids.…”

Section: Etiology Of Seborrheic Dermatitismentioning

confidence: 99%

New Insights into the Etiopathogenesis of Seborrheic Dermatitis

Argirov¹,

Bakardzhiev²

2017

CRDOA

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Seborrheic dermatitis represents a chronic, widespread skin disease that is considered a multifactorial disorder influenced, in part, by Malassezia spp.opportunistic activities as well as by various endogenous and exogenous factors. This review systematizes the recent scientific achievements in the field of insufficiently elucidated etiology and pathogenesis of seborrheic dermatitis. IntroductionSeborrheic dermatitis is initially described by P. G. Unna in 1887 and the association with Malassezia yeasts is accepted up to the middle of the 20th century, when the observed increased epidermal cell turnover gradually prompts researchers to characterize this condition as being intrinsic to the skin[1, 2].Seborrheic dermatitis is common dermatological problem that affects the seborrheic areas of the body. It is considered the same basic condition like dandruff sharing many features and responding to similar treatments, differing only in locality and severity. Current use of varying terms for seborrheic dermatitis such as sebopsoriasis, seborrheic eczema, dandruff, and pityriasis capitis reflects the complex nature of this common skin pathology [3]. Much controversy remains regarding the pathogenesis of seborrheic dermatitis and its classification in the spectrum of cutaneous diseases as a form of dermatitis, a fungal disease, or an inflammatory disease, closely related with psoriasis.The prevalence of seborrheic dermatitis peaks when sebaceous gland activity is high, during the first three months of life (infantile seborrheic dermatitis), during puberty and when sebum excretion is reduced after the age of 50 years [2]. Because of smaller sebum production, seborrheic dermatitis flares occur more often in spring than in summer. Disease flare could be associated with altered population dynamics affected not only by variations in sebaceous gland activity but also by modifications in other nutrients supplied by sweat, such as essential amino acids like glycine and tryptophan.Glycine stimulates the fast growth of M. furfur and after its exhaustion yeast cells employ tryptophan as a nitrogen source, increasing the production of indolic metabolites [4]. Such cycles of population growth, bioactive indole production, and subsequent deprivation of nutrients result in insufficiently masked antigens and ligands on the surface of the yeast cells leading to immune system activation.Seborrheic dermatitis occurs on the scalp as well as on face, retroauricular area, and the upper chest, causing flaking, scaling, inflammation, pruritus, and, sometimes, marked erythema [5]. Flaking is usually white-to-yellowish, and may be oily or dry. Various intrinsic and environmental factors, such as sebaceous secretions, skin surface fungal colonization, individual susceptibility, and interactions between these factors play a pathogenetic role in seborrheic dermatitis. Etiology of Seborrheic DermatitisThere are three principal factors that play a role in the etiology of seborrheic dermatitis [6]: sebaceous gland secretion, alteration in col...

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Section: Etiology Of Seborrheic Dermatitismentioning

confidence: 99%

New Insights into the Etiopathogenesis of Seborrheic Dermatitis

Argirov¹,

Bakardzhiev²

2017

CRDOA

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“…Seborrheic dermatitis (SD) is a common, recurrent disease with chronic progression that affects seborrheic areas, such as skin in regions of the chest presternal area, face, nasolabial area and scalp 1 . SD is usually known as "bran" among adolescents and adults 2 .…”

Section: Introductionmentioning

confidence: 99%

Personality traits and common psychiatric conditions in patients with seborrheic dermatitis

Gül¹,

Karaaslan²,

Çölgeçen³

2017

Arch. Clin. Psychiatry (São Paulo)

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Background: Seborrheic dermatitis is a skin disease in which psychological factors play a central role in its onset, exacerbation and remission. Objective: The aim of this study was to investigate personality traits and common psychiatric conditions in patients with SD. Methods: Outpatients who were admitted to the Bozok School of Medicine Department of Dermatology complaining of SD and who volunteered for study were included. Symptom Checklist 90 -Revised (SCL-90-R) and Eysenck Personality Questionnaire -Revised Short Form (EPQ-RSF) were administered before treatment to 50 patients who fulfilled the criteria for inclusion in the study. Results compiled from the 50 subjects were compared to a control group that was comprised of 50 healthy volunteers. Results: Of the 50 patients that were included in the study, 25 were female and 25 were male. The Global Symptom Index (GSI; Z = -6.96, P < 0.001), Somatization (Z = -6.59, P < 0.001), Depression (Z = -7.11, P < 0.001), and Anxiety (Z = -6.64, P < 0.001) subscales of the SCL-90-R were evaluated. Statistically significantly higher scores were obtained from patients with SD in comparison with the control group on all of these subscales. In addition, the EPQ-RSF Neuroticism subscale was statistically significantly higher (Z = -4.99, P < 0.001) in patients with SD. Discussion: Our results showed that common psychiatric conditions are considerably frequent in SD patients. More importantly, neurotic personality characteristics were much more frequent in these patients. These findings suggest SD to be a psychosomatic disorder that requires a multi-disciplinary approach.

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“…İnfantil başlangıçlı SD yaşamın ilk üç ayında görülürken, erişkin başlangıçlı SD 20-40 yaşları arasında sıktır. 10 Erkeklerde daha sık görü-len SD, genellikle pubertede başlar ve 40'lı yaşlarda pik yapar. 3 Kış aylarında hastalığın şiddeti artarken, yaz aylarında ultraviyole (UV)'nin etkisiyle hastalığın görünümünde iyileşme gözlenir.…”

Section: Epi̇demi̇yoloji̇unclassified

“…23,24 Hastalığın, puberte dönemi dışında da görülmesi ve erkeklerde sık gözlenmesi, androjenlerin pilosebase ünite etki ettiklerini düşündürmektedir. 10,25 7. DİĞER FAKTÖRLER SD'li hastalar ve çocukları arasında SD yönünden pozitif korelasyon bulunmuş, tek yumurta ikizleri arasında SD insidansı artmış olarak saptanmıştır.…”

Section: Hormonal Faktörlerunclassified

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Seborrheic Dermatitis: Review

Aksoy¹,

ARICA²

2016

Turkiye Klinikleri J Dermatol

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deri gibi sebase bezlerden zengin alanlarda yerleşir. Özellikle adolesan ve postadolesan yaş grubunu etkileyen SD, genel populasyonda %3-5, gençlerde %1-3 oranında görülür. İmmün yetmezlikli hastalarda daha yüksek oranlarda görülen SD, infantil başlangıçlı SD ve erişkin başlangıçlı SD olarak iki gruba ayrılabilir. Nedeni tam olarak bilinmeyen, etiyolojisinde birçok faktörün rol oynadığı multifaktöriyel bir hastalıktır. Bu faktörler stres, androjenler, depresyon, yorgunluk, mikroanjiyopatik olabilen vasküler bozukluklar, basınç değişiklikleri gibi atmosfer değişiklikleri, mevsimler, giyim, beslenme biçimleri ve yiyecek allerjileri, otoimmünite, klimakterik değişiklikler, Malassezia furfur, başka nedenlerle alınan ilaçlar, riboflavin, piridoksin, biyotin eksiklikleri gibi birçok faktördür. Seboreik dermatit lezyonlarının histopatolojisi, psöriyazis ve spongiyotik dermatitin histopatolojik bulgularının kombinasyonu şeklindedir. Klinik olarak ayırıcı tanısı ise tutulan lokalizasyona göre değişiklik göstermesidir. Hastalığın şiddetine, morfolojik değişikliklere ve önceki tedavilere verilen yanıta göre seçilen tedavi, daha çok alevlenmeleri kontrol altına almaya yöneliktir. Antifungaller, retinoidler, kortikosteroidler ve fototerapi, bu amaçla kullanılan sistemik tedavi seçenekleridir. Aynı amaç için kullanılan topikal tedavi seçenekleri çok çeşitli olup, salisilik asit, kömür katranı, ardıç katranı, selenyum sülfit, çinko piritiyon gibi keratolitik ajanlar; azoller, alilaminler, benzilaminler, hidroksipiridonlar gibi antifungaller; takrolimus ve pimekrolimus gibi immünmodülatörler; kepek şampuanı, antifungal ajanlar ve topikal steroidleri içeren kombine tedaviler; lityum süksinat, lityum glukonat gibi lityum bileşikleri; kortikosteroidler; metronidazol; 1-24 dihidroksikalsiferol; çay ağacı yağı; 'borage' yağı; aloe vera ekstresi; propilen glikol gibi birçok seçeneği içerir. Bu çalışma, SD etiyopatogenezi, kliniği ve tedavisi ile bu alanda mevcut güncel literatürleri içermektedir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Dermatit,seboreik; etiyoloji; tedavi; tanı A AB BS S T TR RA AC CT T Seborrheic dermatitis is a chronic relapsing inflammatory skin disorder clinically characterized by scaling and poorly defined erythematous patches. Seborrheic dermatitis has a distinctive distribution in areas rich in sebaceous glands -the scalp, eyebrows, glabella, nasolabial and nasofacial folds, cheeks, peri-auricular skin, presternal and interscapular areas. SD especially affecting adolescence and postadolescence is seen in both general and young population with ratios 3-5%, 1-3%, respectively. Seborrheic dermatitis seen at higher rates in patients immunocompromised, can be divided into infantile-onset SD and adult-onset SD. Seborrheic dermatitis is a multifactorial disease that many factors play a role in it's ethiology, although the reason of SD is exactly unknown. These factors are stress, androgens, depression, fatigue, vascular disorder which can be microangiopathic, athmosphere changes such as pressure alter...

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Seborrheic dermatitis

Cited by 233 publications

References 173 publications

New Insights into the Etiopathogenesis of Seborrheic Dermatitis

New Insights into the Etiopathogenesis of Seborrheic Dermatitis

Personality traits and common psychiatric conditions in patients with seborrheic dermatitis

Seborrheic Dermatitis: Review

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