Sebacoyl Isothiocyanate in the Synthesis of Bis (1,3,4-Thiadiazole, 1,3,4-Thiadiazolo[3,2-a]Pyridine, 4-Thiazolidinone, Chromenes, and Naphtho[1,2-b][1,4]Oxazine) Derivatives

Abstract

Reaction of sebacoyl isothiocyanate with cyanoacetic acid hydrazide afforded N 1 ,N 10 -bis (1,3,4-thiadiazole) derivative which used as key precursor for the preparation of bis (1,3,4-thiadiazolo[3,2-a]pyridine, 4-thiazolidinone, chromene, and naphtho[1,2-b][1,4]oxazine) derivatives. The chemical structures of novel compounds were proven by spectroscopic analyses.

Elucidating the biological activities of thiadazole derivatives against Vibrio cholerae: Insights from DFT, spectroscopic studies, molecular docking and ADMET

“…This result suggests the comprehensible stability of the compound in the gaseous phase and a slight difference in its stability in various solvents, which is attributed to solvation effects. This nding aligns with the reported literature [21].…”

“…In the same vein, the CH functional group showed a symmetric stretching mode of vibration with an experimental value ranging from 2944-3042 cm ¹ and a theoretical value ranging from 3002-3043 cm ¹. This result therefore suggests the stability of the compound even when polar solvents are included, which is consistent with the reported literature [21].…”

“…From the analytical data, the empirical formula of the studied compound was observed to be C 32 H 28 N 6 O 6 S 2 , which agrees with the values calculated for C, H, and N (see ref [21]).…”

“…The frequency in different solvents and the gas phase falls between 3553 and 3557 cm ¹ with the same vibration mode known as symmetrical stretching. The experimental frequency of falls was 3225 cm ¹, as reported by Hamdy [21]. All the solvents (TDZD-ethanol, TDZD-DMSO, and TDZD-water) exhibited the same theoretical value of 3553 cm ¹, while TDZD-Gas exhibited a different value at 3557 cm ¹.…”

“…By propelling the boundaries of scienti c understanding in this critical domain, this research holds promise for reshaping the trajectory of strategies against cholera and paves the way for more effective interventions in the future. This compound was synthesized and reported by Hamdy [21]. A mixture of 4 (0.446 g, 1 mmol), salicylaldehyde (0.244 g, 2 mmol) and 0.5 g of fused AcONa in AcOH (30 mL) was re uxed for 2 hours.…”