Sebaceous Gland Metaplasia in the Oesophagus of a Cynomolgus Monkey (Macaca fascicularis)

Esch, Eric van; Brennan, Susan

doi:10.1016/j.jcpa.2011.11.201

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Another protective mechanism includes higher expression of protective molecules, such as the cationic antimicrobial peptides cathelicidin and β-defensins 2 and 3, 33 which are characteristic of carnivorous animals that have a less keratinized esophagus. The human and primate esophagi 34 are not keratinized, and therefore it is plausible that esophagus-specific proteases, such as CAPN14, are a means of protecting the integrity of esophageal tissue (Fig 2). This hypothesis is supported by correlative evidence that CAPN14 mRNA expression in pigs, a species with keratinized esophagus, 32 is virtually undetectable 7 and by evolution of cationic antimicrobial peptides, 35 particularly defensins, 36 that provide antifungal resistance of human esophageal surface.…”

Section: Gene Structure and Conservationmentioning

confidence: 99%

Calpain-14 and its association with eosinophilic esophagitis

Litosh

Rochman

Rymer

et al. 2017

Journal of Allergy and Clinical Immunology

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Calpains are a family of intracellular, calcium-dependent cysteine proteases involved in a variety of regulatory processes, including cytoskeletal dynamics, cell-cycle progression, signal transduction, gene expression, and apoptosis. These enzymes have been implicated in a number of disease processes, notably for this review involving eosinophilic tissue inflammation, such as eosinophilic esophagitis (EoE), a chronic inflammatory disorder triggered by allergic hypersensitivity to food and associated with genetic variants in calpain 14 (CAPN14). Herein we review the genetic, structural, and biochemical properties of CAPN14 and its gene product CAPN14, and its emerging role in patients with EoE. The CAPN14 gene is localized at chromosome 2p23.1-p21 and is most homologous to CAPN13 (36% sequence identity), which is located 365 kb downstream of CAPN14. Structurally, CAPN14 has classical calpain motifs, including a cysteine protease core. In comparison with other human calpains, CAPN14 has a unique expression pattern, with the highest levels in the upper gastrointestinal tract, particularly in the squamous epithelium of the esophagus. The CAPN14 gene is positioned in an epigenetic hotspot regulated by IL-13, a TH2 cytokine with increased levels in patients with EoE that has been shown to be a mediator of the disease. CAPN14 induces disruptive effects on the esophageal epithelium by impairing epithelial barrier function in association with loss of desmoglein-1 expression and has a regulatory role in repairing epithelial changes induced by IL-13. Thus CAPN14 is a unique protease with distinct tissue-specific expression and function in patients with EoE and is a potential therapeutic target for EoE and related eosinophilic and allergic diseases.

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Section: Gene Structure and Conservationmentioning

confidence: 99%

Calpain-14 and its association with eosinophilic esophagitis

Litosh

Rochman

Rymer

et al. 2017

Journal of Allergy and Clinical Immunology

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“…Sebaceous gland cell metaplasia most likely originates from pluripotential basal cells within the squamous esophageal (or buccal) epithelium 114 .…”

Section: Digestive Systemmentioning

confidence: 99%

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (<i>M. fascicularis</i>)

et al. 2021

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in most tissues and organs from the nonhuman primate used in nonclinical safety studies. Some of the lesions are illustrated by color photomicrographs. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous lesions as well as lesions induced by exposure to test materials. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature for lesions in laboratory animals will provide a common language among regulatory and scientific research organizations in different countries and increase and enrich international exchanges of information among toxicologists and pathologists.

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Diagnostic pitfall of sebaceous gland metaplasia of the esophagus

Chiu¹,

Wu²,

Lu³

et al. 2014

WJC

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We investigated the sebaceous gland metaplasia (SGM) of the esophagus and clarified the evidence of misdiagnosis and its diagnosis pitfall. Cases of pathologically proven SGM were enrolled in the clinical analysis and reviewed description of endoscope. In the current study, we demonstrated that SGM is very rare esophageal condition with an incidence around 0.00465% and an occurrence rate of 0.41 per year. There were 57.1% of senior endoscopists identified 8 episodes of SGM. In contrast, 7.7% of junior endoscopists identified SGM in only 2 episodes. Moreover, we investigated the difference in endoscopic biopsy attempt rate between the senior and junior endoscopist (P = 0.0001). The senior endoscopists had more motivation to look for SGM than did junior endoscopists (P = 0.01). We concluded that SGM of the esophagus is rare condition that is easily and not recognized in endoscopy studies omitting pathological review.

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Sebaceous Gland Metaplasia in the Oesophagus of a Cynomolgus Monkey (Macaca fascicularis)

Cited by 3 publications

References 20 publications

Calpain-14 and its association with eosinophilic esophagitis

Calpain-14 and its association with eosinophilic esophagitis

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (<i>M. fascicularis</i>)

Diagnostic pitfall of sebaceous gland metaplasia of the esophagus

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