Sebaceous gland hyperplasia, human immunodeficiency virus and highly active anti-retroviral therapy

Short, K. A.; Williams, A.; Creamer, Daniel; Fuller, L.C.

doi:10.1111/j.1365-2230.2007.02670.x

Cited by 9 publications

(3 citation statements)

References 4 publications

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“…27 A single case report associating SH with the start of highly active antiretroviral therapy for HIV has been published. 36 Short et al 36 also speculate that SH may result from immunosuppression from HIV in this case or as a direct medication effect.…”

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confidence: 91%

Sebaceous lesions and their associated syndromes: Part I

Eisen¹,

Michael²

2009

Journal of the American Academy of Dermatology

126

114

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Sebaceous neoplasms have long been a source of confusion to dermatologists and pathologists alike. Disagreements regarding nomenclature, classification, and management have been longstanding. Sebaceous lesions represent a broad spectrum of interesting entities that range from hamartomas, hyperplasias, and benign tumors to highly malignant neoplasms. This article discusses the clinical and pathologic features of sebaceous hyperplasia, nevus sebaceous of Jadassohn, sebaceous adenoma, seboacanthoma, sebaceous epithelioma, sebaceoma, mantleoma, basal cell carcinoma with sebaceous differentiation, sebomatricoma (sebomatrixoma), and sebaceous carcinoma. Controversies regarding these lesions will be explored, and any relationship with Muir-Torre syndrome will be discussed.

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mentioning

confidence: 91%

Sebaceous lesions and their associated syndromes: Part I

Eisen¹,

Michael²

2009

Journal of the American Academy of Dermatology

126

114

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“…Muir–Torre syndrome was considered; therefore, a systemic examination was performed, and no malignant suspected lesion was found. A test for the human immunodeficiency virus, linked to sebaceous adenoma,5 was negative.…”

Section: Case Reportmentioning

confidence: 99%

“…Sebaceous adenomas were first reported by Van Walbeek3 in 1949, and were characterized as benign tumors that present clinically as tan, pink, or yellow nodules or papules, usually approximately 5 mm in the largest size 2,4. Like most sebaceous proliferations, these tumors typically arise in the head and neck regions of older individuals,1 although sebaceous neoplasms in the eyelid associated with Muir–Torre syndrome have been reported 5–7. Most sebaceous carcinomas arising in the periocular region of elderly patients are aggressive lesions.…”

Section: Introductionmentioning

confidence: 99%

A case of sebaceous adenoma of the eyelid showing excessively rapid growth

Takayama¹,

Usui²,

Ito³

et al. 2013

OPTH

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BackgroundSebaceous adenomas are found mainly in elderly individuals and are usually tan, pink, or yellow nodules or papules, usually approximately 5 mm in the largest size.Case reportA 65-year-old man presented with a progressively enlarging exophytic lesion in the right eyelid for 3 months. External examination revealed a yellowish-pink growth measuring 18 × 13 × 14 mm. The lesion surface was covered by palpebral conjunctiva with fine papillary projections, vascularity, crusting, and ulceration. Two weeks later, the growth enlarged to 20 × 14 × 14 mm, and ulceration also expanded. An excisional biopsy with clear resection margins was performed. No malignancy was found in the stump. Histopathologically, the lesion was located principally within the cutaneous compartment and composed of multiple circumscribed sebaceous lobules, separated, and exhibiting no cytologic atypia. Cystic change was not evident, and no infiltrative growth pattern, pagetoid lesions, mitotic figures, and lymphovascular space invasion were observed. The Ki-67 nuclear antigen was detected in 10%–15% of cells located in the basal zone of the nodule. Fluorescence in situ hybridization showed low human epidermal growth factor receptor 2 amplification, suggesting no genetic changes. The clinical findings, lack of infiltrative border, low Ki-67 index, and low proliferative ability support a diagnosis of sebaceous adenoma.ConclusionSebaceous adenoma that shows excessively rapid growth due to hyperplasia may appear to be malignant. Histopathology, fluorescence in situ hybridization, and Ki-67 were useful to the diagnosis of the adenoma. Excisional biopsy with clear resection margins must be performed in rapidly growing tumors.

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Sebaceous Hyperplasia and Rhinophyma

Requena

Sangüeza

2017

Cutaneous Adnexal Neoplasms

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Sebaceous gland hyperplasia, human immunodeficiency virus and highly active anti-retroviral therapy

Cited by 9 publications

References 4 publications

Sebaceous lesions and their associated syndromes: Part I

Sebaceous lesions and their associated syndromes: Part I

A case of sebaceous adenoma of the eyelid showing excessively rapid growth

Sebaceous Hyperplasia and Rhinophyma

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