Sebaceous Carcinoma of the Eyelids Treated by Mohs Micrographic Surgery: Report of Nine Cases with Review of the Literature

Snow, Stephen N.; Larson, Paul O.; Lucarelli, Mark J.; Lemke, Bradley N.; Madjar, David

doi:10.1046/j.1524-4725.2002.01306.x

Cited by 85 publications

(89 citation statements)

References 37 publications

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“…Most case reports of sebaceous carcinoma demonstrate that women are more likely to develop this cutaneous malignancy, and 1 major review stated that >70% of cases occur in women. 1,[7][8][9][10] Our data are more supportive of other studies, which reported a relatively equal predisposition for the development of sebaceous carcinoma in men and women. OR indicates odds ratio; CI, confidence interval.…”

Section: (344)supporting

confidence: 89%

A retrospective review of 1349 cases of sebaceous carcinoma

Dasgupta

Wilson

2008

Cancer

321

294

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BACKGROUD:Sebaceous carcinoma is a rare and aggressive cutaneous carcinoma. It is believed that this malignancy predominates in the periocular region and occurs more frequently in Asian populations and in women. The objective of the current study was to analyze demographic characteristics and outcomes for patients with this malignancy from a large United States‐based population registry.METHODS:An analysis of the National Cancer Institute's Surveillance, Epidemiology, and End Results database from 1973 through 2004 was performed.RESULTS:Of 1349 patients who were identified, 54% were men, 86.2% were white, and 5.5% were of Asian/Pacific Islander ancestry. The median age at diagnosis was 73 years. The most frequent site of disease was the eyelid (38.7%). The population‐matched 5‐ and 10‐year age‐matched relative survival rate was 91.9% (standard error [SE], 1.9%) and 79.2% (SE, 3.7%), respectively. Cause of death was attributable to cancer in 31% of patients. Orbital involvement did not predict for worsened survival compared with nonorbital involvement (5‐year overall survival, 75.2% vs 68%, respectively; P = .66). The overall population‐matched rate of sebaceous carcinoma was highest in whites (2.03 cases per 1000,000; SE, 0.08) versus Asian/Pacific Islanders (1.07 per 1000,000; SE, 0.18; P = .0001) versus blacks (0.48 per 1000,000; SE, 0.11; P < .0001).CONCLUSIONS:The current results support the finding of a predominance of men among patients with sebaceous carcinoma, and no difference was observed in the prognosis for orbital and periorbital involvement. This retrospective analysis also corroborated previous case reports of a higher incidence among patients with advanced age and the highest incidence for sites in the eyelid and skin of the face. The results also established that Asian/Pacific Islander ancestry is not a risk factor for developing sebaceous carcinoma. Cancer 2009. © 2008 American Cancer Society.

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Section: (344)supporting

confidence: 89%

A retrospective review of 1349 cases of sebaceous carcinoma

Dasgupta

Wilson

2008

Cancer

321

294

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“…Sebaceous gland carcinoma, although relatively rare, is described as being responsible for about 10% of all eyelid malignancies with a propensity for the upper eyelid, female sex, and often affecting adults in the sixth to seventh decades [5,7,15]. We had one male patient with inferior eyelid involvement in the seventh decade of life, which accounted for 5% of our cases.…”

Section: Discussionmentioning

confidence: 92%

Orbital exenteration for eyelid skin carcinoma

et al. 2011

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Exenteration of the orbit is a disfiguring and destructive procedure; it is generally performed for orbital malignancies and often provides a significant reconstructive challenge. Our purpose was to evaluate the clinical indications for orbital exenteration in a tertiary referral center and to assess the reconstructive options employed. A retrospective nonrandomized analysis was performed, selecting all patients undergoing orbital exenteration over a 5-year period, between January 2005 and January 2010. Patient demographics, tumor characteristics, and reconstructive techniques used were evaluated. Twenty patients with a mean age of 76.5 years underwent total orbital exenteration. Basal cell carcinoma was the main operative indication (45%), followed by squamous cell carcinoma (15%). Reconstructive techniques included cover of the raw orbital cavity with a temporal muscular flap in all cases followed with split skin grafting (25%), bilaterally pedicle V-Y advancement flap (10%) and a fasciocutaneous island flap of the retroauricular region (65%). Twenty percent of patients had local complications and all were treated in a satisfactory fashion. Eyelid skin tumors remain an important cause of orbital exenteration. Temporal muscle flap is a reliable and stable reconstructive solution after orbital exenteration and additional aid is supplied with skin grafts or local flaps. This technique ensures a good aesthetic outcome and better situation for later complementary treatments and minimal associated donor site morbidity.

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“…SGC has a recurrence rate of 11-30 % and metastatic spread occurs in 3-25 % [37]. MMS has been shown to offer low recurrence rates in the treatment of SGC [38]; however, SGC tends to exhibit multicentricity, pagetoid spread and non-contiguous growth making the determination of negative margins difficult [31].…”

Section: Discussionmentioning

confidence: 99%