Sebaceous carcinoma arising within an ovarian cystic mature teratoma

Papadopoulos, A.; Ahmed, Hussain Gadelkarim; Pakarian, F.B.; Caldwell, Carole; McNicholas, J.; Raju, K. S.

doi:10.1046/j.1525-1438.1995.05010076.x

Cited by 12 publications

(22 citation statements)

References 8 publications

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“…In general, the prognosis of teratomas with malignant transformationisaffectedbythedegreeoftumorextension, capsularandbloodvesselinvasion [6].Inourcase,thetumor was restricted to the ovary and did not infiltrate capsule, blood vessels, adjacent structures or omentum. None of the sebaceous carcinomas arising in mature ovarian teratomas reported until now developed recurrence or metastasis, suggestingthatthiscarcinomahasafavorableoutcomeatdifferentstagesofdiagnosis [3][4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 76%

“…Squamous cell carcinoma is the most common malignantcomponentfound,correspondingtoupto80%of neoplasms, and the prognosis is poor [2]. However, several malignancies have also been reported, including adenocarcinomas, adenosquamous carcinomas, undifferentiated carcinomas,sarcomas,carcinosarcomasandmelanomas.Casesof puresebaceouscarcinomasareexceedinglyrarelyreportedin theEnglishliterature [3][4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…Sebaceous epithelioma and basal cell carcinoma with sebaceousdifferentiationmustbeconsideredinthedifferential diagnosis.Thepresenceofobviousmalignantsebaceousdifferentiationinnearlyeverytumornestandlackofperipheral palisadingandperi-tumoralmyxoidstromaexcludethesediagnoses.Moreover,thelobulatedgrowthpatternwithpushing ratherthaninfiltrativebordersandthematuresebaceouscells dominatingoverbasaloidcellsarehelpfulmorphologicalfeaturesforthediagnosisofasebaceousepithelioma [6][7][8].Since expression of EMA is exceptional in basal cell carcinomas, focalEMAstaining,asinourcase,isusefulindistinguishing sebaceouscarcinomasfrombasalcellcarcinomas.…”

Section: Discussionmentioning

confidence: 99%

“…None of the sebaceous carcinomas arising in mature ovarian teratomas reported until now developed recurrence or metastasis, suggestingthatthiscarcinomahasafavorableoutcomeatdifferentstagesofdiagnosis [3][4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…Thereareonly6reportsofsebaceouscarcinomaarisingwith-in a benign teratoma of the ovary [3][4][5][6][7][8]. We present an additionalcasealongwithabriefreviewoftheliteratureonthis rareneoplasm.…”

Section: Introductionmentioning

confidence: 99%

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A Case of Sebaceous Carcinoma Arising within a Benign Ovarian Cystic Teratoma

Venizelos

Tatsiou²,

Roussos³

et al. 2009

Onkologie

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Background: Mature cystic teratoma, also known as dermoid cyst, is the most common germ cell tumor of the ovary. Malignant change in a component of a mature ovarian teratoma is rare, occurring in less than 2% of cases, with squamous cell carcinoma corresponding to 80% of such neoplasms. Pure sebaceous carcinoma is exceedingly rare, with only 6 reported cases thus far. Case Report: A 74-year-old woman presented with lower abdominal pain due to a palpable mass in the right abdomen. Abdominal and pelvic ultrasound as well as computed tomography demonstrated a heterogenic tumor of the right ovary. A total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. Histological examination of the tumor showed features of a well-differentiated sebaceous carcinoma arising within a mature cystic teratoma. Conclusions: This is an extremely rare ovarian malignancy of which the clinical behavior and optimal management are not well established. Differential diagnosis with other malignant neoplasms arising in mature cystic teratomas is exceedingly important for treatment and prognosis.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A Case of Sebaceous Carcinoma Arising within a Benign Ovarian Cystic Teratoma

Venizelos

Tatsiou²,

Roussos³

et al. 2009

Onkologie

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Clinicopathological and immunohistochemical features of a sebaceous carcinoma arising within a benign dermoid cyst of the ovary

Ribeiro‐Silva

Chang

Bisson³

et al. 2003

Virchows Archiv

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Pure sebaceous neoplasms arising in dermoid cysts of the ovary are exceedingly rare. A 63-year-old female with abdominal swelling and pain underwent a right salpingo-oophorectomy that showed a unilocular cyst weighing 830 g and measuring 15x12x10 cm, filled with sebaceous material containing a few hair shafts. The cyst wall exhibited plaques protruding into the cavity of the cyst. Microscopy revealed a dermoid cyst with nests and lobules of atypical and infiltrating sebaceous cells surrounded by basaloid cells. The tumor cells stained diffusely for high-molecular-weight cytokeratins and focally for cytokeratin 7, cytokeratin 19, epithelial membrane antigen and carcinoembryonic antigen in the immunohistochemistry study. Low-molecular-weight cytokeratins, cytokeratin 20, vimentin, S100, p63, estrogen receptor, progesterone receptor, p53 and c-erbB-2 were negative in tumoral cells. The proliferative labeling index (Ki67 and proliferating cell nuclear antigen) was low. Basal cell carcinoma with sebaceous differentiation and sebaceoma must be considered in the differential diagnosis. However, the presence of obvious malignant sebaceous differentiation in nearly every tumor nest and lack of peripheral palisading and peri-tumoral myxoid stroma excluded these diagnoses. Some histogenetic concepts relevant to this case are discussed along with a brief review of this neoplasm. To our knowledge, this is the sixth case report of a sebaceous carcinoma arising in a mature cystic teratoma of the ovary.

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Endoscopic management of a sebaceous carcinoma arising in a mature cystic teratoma of the ovary

Bolla

Hochstetter²,

Hornung

2010

Gynecol Surg

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Malignant transformation of a mature cystic teratoma (MCT) of the ovary is extremely rare. Squamous cell carcinoma is the most common malignancy, which occurs in MCT and accounts for ∼80% of all cases. We describe the eighth undisputed case of a pure sebaceous carcinoma arising in a teratoma of the ovary. A 45-year-old woman underwent laparoscopic hysterectomy, bilateral salpingo-oophorectomy with pelvic and paraaortic lymphadenectomy. The final stage was pT1a, pN0 (0/30), M0, G2. The carcinoma was localized within a dermoid cyst not involving the capsule or adjacent abdominal structures. Complete tumor excision without iatrogenic tumor cell dissemination and proper staging are important for the prognosis and treatment and should be performed as soon as possible after diagnosis. Unfortunately, the very small number of cases published does not allow an evidencebased therapeutic management.

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Sebaceous carcinoma arising within an ovarian cystic mature teratoma

Cited by 12 publications

References 8 publications

A Case of Sebaceous Carcinoma Arising within a Benign Ovarian Cystic Teratoma

A Case of Sebaceous Carcinoma Arising within a Benign Ovarian Cystic Teratoma

Clinicopathological and immunohistochemical features of a sebaceous carcinoma arising within a benign dermoid cyst of the ovary

Endoscopic management of a sebaceous carcinoma arising in a mature cystic teratoma of the ovary

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