Sebaceous Basal Cell Carcinoma - An Ultrastructural Study

Abstract

Basal cell carcinoma with sebaceous gland differentiation has been described in mice and humans but spontaneous skin tumors of this type are uncommon in the rat.The tumor specimen was taken from a 26 month old male Wistar rat. Electron microscopy specimens were fixed by immersion in cacodylatebuffered 4% glutaraldehyde, post-fixed in 1% osmium tetroxide, dehydrated, cleared and embedded by standard procedures. Semi-thin (μm) sections were stained with ethanolic uranyl acetate followed by lead citrate, then examined on a Philips EM201 electron microscope.