Sebaceous Adenocarcinoma of the External Auditory Canal in a New Zealand White Rabbit

Suckow, Mark A.; Rebelatto, M. C.; Schulman, Alexis; HogenEsch, Harm

doi:10.1053/jcpa.2002.0585

Cited by 14 publications

(7 citation statements)

References 8 publications

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“…Necropsy revealed tumor invasion of the thoracic wall and ribs. SC has been additionally reported in nonocular locations in the abdominal skin of a gerbil, 13 in the perineum and vulva of a Friesian cow, 14 in the salivary gland of a cat, 15 and in the external auditory ear canal of a New Zealand white rabbit 16 . Only histopathologic characterization, but not clinical follow‐up, was available for these cases.…”

Section: Combined Excision and Intralesional Bevacizumab For Sebaceoumentioning

confidence: 99%

Combined excision and intralesional bevacizumab for sebaceous carcinoma of the eyelid in an Amur tiger (Panthera tigris altaica)

Edelmann

Lassaline

Klein³

et al. 2012

Veterinary Ophthalmology

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An 18-year-old zoo-kept female Amur tiger presented with an approximately 5 mm diameter lateral canthal eyelid mass in the left eye which grossly appeared red and irregular. The mass was completely excised via lateral canthoplasty. Histopathologic evaluation was consistent with a diagnosis of sebaceous cell carcinoma, which is a potentially aggressive cutaneous neoplasm. The sebaceous carcinoma recurred within 3 months and slowly increased in size until a second surgical excision was performed 9 months following the first surgery. The second surgical excision was combined with intralesional injection of 10 mg of the antiangiogenic drug bevacizumab. Histology confirmed the diagnosis. The tiger was euthanized 16 months postoperatively for reasons unrelated to, and without recurrence of, the eyelid neoplasm. At postmortem, no gross periocular or metastatic lesions were noted, and histopathology of the lateral canthus provided no evidence of recurrence. Surgical excision combined with intralesional bevacizumab treatment induced life-long resolution of the sebaceous carcinoma. Bevacizumab treatment may be associated with the regression of periocular angiogenic proliferative conditions, including neoplasia, by inhibiting angiogenesis.

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Section: Combined Excision and Intralesional Bevacizumab For Sebaceoumentioning

confidence: 99%

Combined excision and intralesional bevacizumab for sebaceous carcinoma of the eyelid in an Amur tiger (Panthera tigris altaica)

Edelmann

Lassaline

Klein³

et al. 2012

Veterinary Ophthalmology

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“…22 Epithelial nonviral skin neoplasms have been cited in sporadic case reports or few case series and include basal cell tumors 11,24,36,37,48 and squamous cell carcinomas. 14,48 Single case reports describe trichoepithelioma, 1 tricholemmoma, 28 and sebaceous gland carcinoma 32,42 in rabbits. Equally few mesenchymal tumors have been described, and these include lipomas, 25 neurofibrosarcoma, 3 hemangiosarcoma, 30 myxosarcoma, 35 malignant fibrous histiocytoma, 51 and extraskeletal osteosarcoma.…”

mentioning

confidence: 99%

Cutaneous Neoplasms in Pet Rabbits: A Retrospective Study

et al. 2007

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Abstract. Over a 16-year period, 190 tumors and tumorlike lesions from 179 pet rabbits were submitted for histopathologic examination. A total of 23 different tumor types and 1 tumorlike lesion were diagnosed. The most common diagnoses were trichoblastoma, collagenous hamartoma, and Shope fibroma. Viral-induced tumors were Shope fibroma (19) and Shope papilloma (2). Common nonviral epithelial tumors included trichoblastoma (59), squamous cell carcinoma (5), squamous papilloma (4), trichoepithelioma (3), and apocrine carcinoma (3). Common mesenchymal tumors were lipoma (10), liposarcoma (3), myxosarcoma (9), malignant peripheral nerve sheath tumor (8), fibrosarcoma (7), and leiomyosarcoma (4). Malignant melanoma was diagnosed in 8 rabbits. Collagenous hamartomas were diagnosed in 26 rabbits. Mesenchymal proliferations occurred significantly more often in male rabbits than in females. Collagenous hamartomas and myxosarcomas occurred exclusively in male animals, and 3 rabbits had multiple collagenous hamartomas. Immunohistochemistry was applied in cases in which a definite diagnosis could not be reached on hematoxylin and eosin slides. Follow-up information was received in 19 cases. Carcinomas recurred (2 of 3) or metastasized (1 of 3), whereas sarcomas frequently recurred (7 of 12). One malignant melanoma (1 of 3) and one poorly differentiated round cell neoplasm recurred (1 of 1). This is the first comprehensive retrospective analysis on skin neoplasia in pet rabbits.

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“…Abscesses and viral skin tumours, such as myxomatosis and papillomas, can be seen as skin nodules in pet rabbits, but spontaneous non‐viral skin tumours are rarely reported in rabbits (Scott and others 2001). Several cases of cutaneous neoplasms have been reported in rabbits, including basal cell carcinoma (Li and Schlafer 1992, Roccabianca and others 1999), squamous cell carcinoma (Greene and Brown 1943, Weisbroth 1994), sebaceous carcinoma (Port and Sidor 1978, Suckow and others 2002), trichoepithelioma (Altman and others 1978) and lymphoma (Hinton and Regan 1978), though, to the authors’ knowledge, no apocrine adenocarcinoma cases have been reported previously.…”

Section: Introductionmentioning

confidence: 87%

Apocrine adenocarcinoma of possible sweat gland origin in a male rabbit

Miwa¹,

Mochiduki²,

Nakayama³

et al. 2006

J of Small Animal Practice

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A five-year-old, male crossbreed rabbit was referred for acute caudal abdominal swelling. On physical examination, the rabbit was slightly depressed and showed an enlarged subcutaneous cyst in the caudal abdomen and an adjacent small, ulcerated solid mass. A drainage tube was placed in the cystic area, and surgical resection of the solid mass was performed. The histopathological diagnosis of the mass was apocrine adenocarcinoma. To the authors' knowledge, this report describes the first case of spontaneous apocrine adenocarcinoma of possible sweat gland origin in a male rabbit.

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Sebaceous Adenocarcinoma of the External Auditory Canal in a New Zealand White Rabbit

Cited by 14 publications

References 8 publications

Combined excision and intralesional bevacizumab for sebaceous carcinoma of the eyelid in an Amur tiger (Panthera tigris altaica)

Combined excision and intralesional bevacizumab for sebaceous carcinoma of the eyelid in an Amur tiger (Panthera tigris altaica)

Cutaneous Neoplasms in Pet Rabbits: A Retrospective Study

Apocrine adenocarcinoma of possible sweat gland origin in a male rabbit

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