Sebaceous adenitis in the Akita: clinical observations, histopathology and heredity

Reichler, Iris M; Hauser, B.; Schiller, Irene; Dunstan, Robert W.; Credille, Kelly M.; Binder, H; Glaus, Toni M; Arnold, S.

doi:10.1046/j.0959-4493.2001.00251.x

Cited by 35 publications

(58 citation statements)

References 10 publications

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“…This is supported by the finding that ciclosporin—when administered before the sebaceous glands are completely lost—produces a drug-dependent clinical and structural response (Linek and others 2005). As certain breeds are more commonly affected than others, a genetic predisposition is suspected and has been proposed for both the Standard Poodle and the Akita (Reichler and others 2001, Hernblad Tevell and others 2008, Pedersen and others 2012). To the authors’ knowledge there is no reported predilection in Elos at this time.…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium avium subspecies hominissuis infection in a dog from Germany with multifocal alopecia, exfoliative dermatitis, hypercalcaemia and subsequent sebaceous atrophy

Hobi

Bettenay²,

Majzoub³

et al. 2015

Vet Record Case Reports

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Mycobacterium avium subspecies hominissuis belongs to the M avium complex and infections with this agent are reported rarely in the dog. A nine-year-old intact female Elo dog was presented with widespread hypotrichosis, erythema and exfoliation. Other clinical signs were polyuria/polydipsia and severe weight loss. No other animals or humans in the household showed any dermatological abnormalities. Multiple skin biopsies identified a pyogranulomatous dermatitis but no causative agent could be detected. Skin tissue culture and PCR revealed M avium subspecies hominissuis. Hypercalcaemia (ionised calcium) was initially present. All other serum biochemistry parameters, chest radiographs, abdominal ultrasound, parathyroid hormone and parathyroid hormone-related protein were within the reference interval. Subsequent to therapy with rifampicin, pradofloxacin and oral fatty acids the pyogranulomatous dermatitis resolved and mycobacteria could not be detected but sebaceous glands were lost histopathologically. This is the first report describing a dog infected with M avium subspecies hominissuis successfully treated with antibiotic therapy and with no zoonotic transmission. BACKGROUND

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Section: Discussionmentioning

confidence: 99%

Mycobacterium avium subspecies hominissuis infection in a dog from Germany with multifocal alopecia, exfoliative dermatitis, hypercalcaemia and subsequent sebaceous atrophy

Hobi

Bettenay²,

Majzoub³

et al. 2015

Vet Record Case Reports

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“…As hipóteses relacionadas à patogenia da adenite sebácea incluem alterações genéticas estruturais primárias da glândula ou dos ductos sebáceos (Farias et al, 2000;Reichler et al, 2001;Scott et al, 2001), resposta imunomediada contra antígenos presentes nos componentes da glândula ou da secreção sebácea (Scott et al, 1996); anormalidades da cornificação, ou defeito no metabolismo dos lipídeos (Scott et al, 1996;Reichler et al, 2001). A adenite sebácea também pode se desenvolver secundariamente a determinadas afecções, sendo observada em várias doenças de base, tais como leishmaniose, demodiciose, alergia alimentar e síndromes úveo-dermatológicas (Gross et al, 1992;White et al, 1995).…”

Section: Introductionunclassified

Adenite sebácea em cães: relato de três casos

et al. 2017

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ResumoA adenite sebácea é uma dermatose incomum em cães, caracterizada por ser uma doença inflamatória que resulta na destruição da glândula sebácea. Embora possa ocorrer em muitas raças, existe uma aparente prevalência em Poodles standard, Vizslas, Akitas e Samoiedas, variando a severidade dos sintomas de acordo com a raça e o tipo de pelagem. O diagnóstico se baseia nos sinais clínicos apresentados pelo paciente e nos achados do exame histopatológico das lesões, que demonstram ausência de glândulas sebáceas e presença de inflamação mínima. A doença é incurável, porém o tratamento pode ser realizado pela aplicação de óleos nas áreas acometidas e administração de imunomoduladores sistêmicos de maneira ininterrupta, evitando assim a recidiva dos sinais clínicos. Objetivou-se descrever três casos de adenite sebácea em cães nos quais os animais apresentaram lesões alopécicas, com formação melicérica multifocais e prurido com intensidade variável de ausente a moderada. O diagnóstico definitivo foi obtido pelo exame histopatológico e o tratamento instituído consistiu da aplicação tópica de ciclosporina diluída em óleo mineral, ou óleo mineral isolado. Pode-se concluir que foi possível diagnosticar a adenite sebácea nos casos descritos, por meio de dados da anamnese, exame clínico e exames complementares. Além disso, vale salientar que os cães malteses não estão listados como predispostos a enfermidade e a utilização da terapia tópica com óleo mineral associado ou não com ciclosporina demonstrou-se ser eficaz no tratamento da adenite sebácea de cães na sua fase crônica.Palavras-Chave: glândula sebácea, óleo, Maltês. AbstractSebaceous adenitis is an unusual dermatosis in dogs, characterized by being an inflammatory disease that results in the destruction of the sebaceous gland. Although it occurs in many breeds, there is an apparent prevalence in standard Poodles, Vizslas, Akitas, and Samoiedas, and the severity of symptoms varies according to breed and coat type. The diagnosis is based on clinical signs presented by the patient and also depend on the histopathological examination of the lesions, which shows absence of sebaceous glands and presence of minimal inflammation. The disease is incurable, but its treatment can be performed by applying oils in the affected areas and also by administering systemic immunomodulators continually to avoid relapse. The present work aims to describe three cases of sebaceous adenitis in dogs, in which the animals presented alopecic lesions, with multifocal meliceric formation and moderate to intense pruritus. The definitive diagnosis was obtained through histopathological examination and the treatment consisted of topical application of mineral oil, or application of cyclosporin diluted in mineral oil. The diagnostic of sebaceous adenitis in the cases described was possible due anamnesis data, clinical examination and complementary tests. In addition, it is worth noting that Maltese dogs are not listed as predisposed to the disease and the use of topical therapy with mineral oil assoc...

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“…Additional features may include orthokeratotic hyperkeratosis, follicular keratosis, mild superficial perivascular dermatitis with neutrophils, eosinophils and plasma cells, or mast cells (Reichler et al . ) or mast cells and lymphocytes (Bardagi et al . 2010), and evidence of secondary pyoderma (intraepidermal pustules, folliculitis and furunculosis).…”

Section: Introductionmentioning

confidence: 99%

Transverse sectioning for histological assessment of sebaceous glands in healthy dogs and canine sebaceous adenitis

Bond

Brooks

2013

J of Small Animal Practice

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Sebaceous adenitis in the Akita: clinical observations, histopathology and heredity

Cited by 35 publications

References 10 publications

Mycobacterium avium subspecies hominissuis infection in a dog from Germany with multifocal alopecia, exfoliative dermatitis, hypercalcaemia and subsequent sebaceous atrophy

Mycobacterium avium subspecies hominissuis infection in a dog from Germany with multifocal alopecia, exfoliative dermatitis, hypercalcaemia and subsequent sebaceous atrophy

Adenite sebácea em cães: relato de três casos

Transverse sectioning for histological assessment of sebaceous glands in healthy dogs and canine sebaceous adenitis

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