Seaweeds as a Source of Proteins for Use in Pharmaceuticals and High‐Value Applications

Okolie, Chigozie Louis; Mason, Beth; Critchley, Alan T.

doi:10.1002/9781119385332.ch11

Cited by 26 publications

(20 citation statements)

References 75 publications

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“…Seaweeds are multi-cellular, macroscopic organisms found in coastal, marine ecosystems and are a rich source of polysaccharides, polyunsaturated fatty acids (PUFAs), enzymes, and bioactive peptides among others (Courtois, 2009; De Jesus Raposo et al, 2013; Ahmadi et al, 2015; Shukla et al, 2016; Okolie et al, 2018). In particular, inter-tidal seaweeds may be exposed to unfavorable conditions including extreme variations in temperature, salinity, and light.…”

Section: Introductionmentioning

confidence: 99%

Ascophyllum nodosum-Based Biostimulants: Sustainable Applications in Agriculture for the Stimulation of Plant Growth, Stress Tolerance, and Disease Management

et al. 2019

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Abiotic and biotic stresses limit the growth and productivity of plants. In the current global scenario, in order to meet the requirements of the ever-increasing world population, chemical pesticides and synthetic fertilizers are used to boost agricultural production. These harmful chemicals pose a serious threat to the health of humans, animals, plants, and the entire biosphere. To minimize the agricultural chemical footprint, extracts of Ascophyllum nodosum (ANE) have been explored for their ability to improve plant growth and agricultural productivity. The scientific literature reviewed in this article attempts to explain how certain bioactive compounds present in extracts aid to improve plant tolerances to abiotic and/or biotic stresses, plant growth promotion, and their effects on root/microbe interactions. These reports have highlighted the use of various seaweed extracts in improving nutrient use efficiency in treated plants. These studies include investigations of physiological, biochemical, and molecular mechanisms as evidenced using model plants. However, the various modes of action of A. nodosum extracts have not been previously reviewed. The information presented in this review depicts the multiple, beneficial effects of A. nodosum -based biostimulant extracts on plant growth and their defense responses and suggests new opportunities for further applications for marked benefits in production and quality in the agriculture and horticultural sectors.

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Section: Introductionmentioning

confidence: 99%

Ascophyllum nodosum-Based Biostimulants: Sustainable Applications in Agriculture for the Stimulation of Plant Growth, Stress Tolerance, and Disease Management

et al. 2019

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“…Microalgae pigments have high commercial value as natural colorants in the nutraceutical, cosmetic, and pharmaceutical industries, as well as applications in clinical research and molecular biology, and as natural dyes in the textile industries, painting and color industries, food colorant and feed additive for poultry (de Morais et al, 2018;Okolie et al, 2019). Bottlenecks for effective pigment production should be overcome, and potential genetic and metabolic approaches could be used to achieve cost-intensive productivity (Saini et al, 2020).…”

Section: Bioactive Pigments From Microalgaementioning

confidence: 99%

Natural Pigments of Microbial Origin

Pailliè-Jiménez

Stincone

Brandelli

2020

Front. Sustain. Food Syst.

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The world demands new solutions and products to be used as dyes for industrial applications. Microbial pigments represent an eco-friendly alternative as they can be produced in large amounts through biotechnological processes and do not present environmental risks, as they are easily decomposable. Moreover, some of these metabolites are recognized for their biological activities, which qualify them for potential uses as food colorants and nutraceuticals, protecting against degenerative diseases related with oxidative stress. Because of their genetic simplicity as compared with plants, microorganisms may be a better source to understand biosynthetic mechanisms and to be engineered for producing high pigment yields. Despite the origin of the pigmented microorganism, it seems very important to develop protocols using organic industrial residues and agricultural byproducts as substrates for pigment production and find novel green strategies for rapid pigment extraction. This review looks for the most recent studies that describe microbial pigments from microalgae, fungi, and bacteria. In particular, the underexploited tools of omics science such as proteomics and metabolomics are addressed. The use of techniques involving mass spectrometry, allows to identify different protein and metabolite profiles that may be associated with a variety of biotechnologically-relevant pathways of pigment synthesis.

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“…Strong antioxidant activities were detected with seaweed extracts (Al-Araby et al, 2020;El-Sheekh et al, 2020). Seaweeds are recognized as a gorgeous origin of natural and bioactive compounds such as polyphenols, vitamins, polysaccharides, peptides, and fatty acids with various functional properties and structures that supply the living organisms with various health benefits (Ganesan et al, 2008;Hayes 2015;Okolie et al, 2018). Furthermore, green, red, and brown algae have compounds with antioxidants (Vega et al, 2020), anti-inflammatory (Yu et al, 2019), antidiabetic (Jia et al, 2020), and anticancer activities (El-Shaibany et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, antidiabetic, anti-inflammatory and anticancer potential of some seaweed extracts

et al. 2022

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This study aims to evaluate the secondary metabolites, cytotoxicity, antioxidant, antidiabetic, anti-inflammatory, and anticancer activities of four selected seaweeds Padina pavonica, Taonia atomaria, Jania rubens, and Corallina elongata. The maximum value of phenolic content (176.7 ± 6.9 mg gallic acid equivalents/g crude extract) and tannin content (26.5 ± 4.3 mg tannic acid equivalents/g crude extract), was shown in the methanol extract of J. rubens and P. pavonica, respectively. While the ethanol extract of T. atomaria recorded the highest values of total flavonoid content (374.1 ±27.4 mg quercetin equivalents/g crude extract) and total saponins content (30.2 ± 0.7 mg cholesterol equivalents/g crude extract, respectively) compared to other seaweeds. Methanol extract of J. rubens and C. elongata exhibited the greatest content of alkaloids (25.8 ± 4.4 and 22.7 ± 2.6 mg/g d wt.). The methanol extract of P. pavonica established the highest DPPH radical scavenging activity (55.7% ± 0.1) at 50 μg/mL. Among the selected seaweed extracts, the ethanol extract of T. atomaria demonstrated the maximum α-amylase inhibition capacity (66.3% ± 0.0). Methanol extract of J. rubens and P. pavonica species effectively prevented the hypotonicity-induced haemolysis in a concentration-dependent manner compared with the diclofenac potassium as a standard anti-inflammatory drug. In vitro, the reported results also supported the safety and non-toxicity of the four seaweed extracts on WI-38 cell line at lower concentrations. J. rubens and P. pavonica methanol extracts recorded the highest cell growth inhibition of the HeLa Cancer Cell Lines compared to other seaweed extracts and the standard drug Cisplatin.

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Seaweeds as a Source of Proteins for Use in Pharmaceuticals and High‐Value Applications

Cited by 26 publications

References 75 publications

Ascophyllum nodosum-Based Biostimulants: Sustainable Applications in Agriculture for the Stimulation of Plant Growth, Stress Tolerance, and Disease Management

Ascophyllum nodosum-Based Biostimulants: Sustainable Applications in Agriculture for the Stimulation of Plant Growth, Stress Tolerance, and Disease Management

Natural Pigments of Microbial Origin

Antioxidant, antidiabetic, anti-inflammatory and anticancer potential of some seaweed extracts

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